{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:29:22Z","timestamp":1790461762050,"version":"4.1.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>To determine factors associated with fluid-attenuated inversion recovery (FLAIR) hyperintense arteries (FLAIR-HAs) on magnetic resonance imaging and their prognostic significance in thrombolysis-treated patients with acute ischemic stroke from the ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) trial alteplase-dose arm.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Patients with acute ischemic stroke (N=293) with brain magnetic resonance imaging (FLAIR and diffusion-weighted imaging sequences) scanned &lt;4.5 hours of symptom onset were assessed for location and extent (score) of FLAIR-HAs, infarct volume, large vessel occlusion (LVO), and other ischemic signs. Logistic regression models were used to determine predictors of FLAIR-HAs and the association of FLAIR-HAs with 90-day outcomes: favorable functional outcome (primary; modified Rankin Scale scores, 0\u20131), other modified Rankin Scale scores, and intracerebral hemorrhage.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Prior atrial fibrillation, LVO, large infarct volume, and anterior circulation infarction were independently associated with FLAIR-HAs. The rate of modified Rankin Scale scores 0 to 1 was numerically lower in patients with FLAIR-HAs versus without (69\/152 [45.4%] versus 75\/131 [57.3%]), as was the subset of LVO (37\/93 [39.8%] versus 9\/16 [56.3%]), but not in those without LVO (25\/36 [69.4%] versus 60\/106 [56.6%]). After adjustment for covariables, FLAIR-HAs were independently associated with increased primary outcome (adjusted odds ratio [95% CI]: overall 4.14 [1.63\u201310.50]; with LVO 4.92 [0.87\u201327.86]; no LVO 6.16 [1.57\u201324.14]) despite an increased risk of hemorrhagic infarct (4.77 [1.12\u201320.26]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>FLAIR-HAs are more frequent in acute ischemic stroke with cardioembolic features and indicate potential for a favorable prognosis in thrombolysis-treated patients possibly mediated by LVO.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01422616.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.028550","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T13:27:37Z","timestamp":1592400457000},"page":"2240-2243","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Thrombolysis Outcomes in Acute Ischemic Stroke by Fluid-Attenuated Inversion Recovery Hyperintense Arteries"],"prefix":"10.1161","volume":"51","clinical-trial-number":[{"clinical-trial-number":"nct01422616","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Zien","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China (Z.Z., J.X.)."},{"name":"The George Institute for Global Health, Faculty of Medicine, University of New South Wales Sydney, Australia (Z.Z., S.Y., C.D., A.M., T.T.-Y., C.C., X.W., X.C., J.C., C.S.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohei","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine, University of New South Wales Sydney, Australia (Z.Z., S.Y., C.D., A.M., T.T.-Y., C.C., X.W., X.C., J.C., C.S.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Delcourt","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine, University of New South Wales Sydney, Australia (Z.Z., S.Y., C.D., A.M., T.T.-Y., C.C., X.W., X.C., J.C., C.S.A.)."},{"name":"Department of Neurology, Royal Prince Alfred Hospital, Sydney Health Partners, Australia (C.D., C.C., C.S.A.)."},{"name":"Sydney Medical School, University of Sydney, Australia (C.D., C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I.","family":"Lindley","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health and Westmead Applied Research Centre, University of Sydney, Australia (R.I.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoujiang","family":"You","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine (S.Y.), National Cerebral and Cardiovascular Center, Osaka, Japan."},{"name":"Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou, China (S.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Malavera","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine, University of New South Wales Sydney, Australia (Z.Z., S.Y., C.D., A.M., T.T.-Y., C.C., X.W., X.C., J.C., C.S.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Torii-Yoshimura","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine, University of New South Wales Sydney, Australia (Z.Z., S.Y., C.D., A.M., T.T.-Y., C.C., X.W., X.C., J.C., C.S.A.)."},{"name":"Division of Neurology, Department of Stroke and Cerebrovascular Diseases (T.T.-Y.), National Cerebral and Cardiovascular Center, Osaka, Japan."},{"name":"Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Science, Japan (T.T.-Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Carcel","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine, University of New South Wales Sydney, Australia (Z.Z., S.Y., C.D., A.M., T.T.-Y., C.C., X.W., X.C., J.C., C.S.A.)."},{"name":"Department of Neurology, Royal Prince Alfred Hospital, Sydney Health Partners, Australia (C.D., C.C., C.S.A.)."},{"name":"Sydney Medical School, University of Sydney, Australia (C.D., C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine, University of New South Wales Sydney, Australia (Z.Z., S.Y., C.D., A.M., T.T.-Y., C.C., X.W., X.C., J.C., C.S.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Chen","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine, University of New South Wales Sydney, Australia (Z.Z., S.Y., C.D., A.M., T.T.-Y., C.C., X.W., X.C., J.C., C.S.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Parsons","sequence":"additional","affiliation":[{"name":"Neurology Department, Royal Melbourne Hospital, University of Melbourne, Australia (M.W.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Demchuk","sequence":"additional","affiliation":[{"name":"Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada (A.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna M.","family":"Wardlaw","sequence":"additional","affiliation":[{"name":"Division of Neuroimaging Science, Edinburgh Imaging and Centre for Clinical Brain Sciences (J.M.W., G.M.), University of Edinburgh, United Kingdom."},{"name":"UK Dementia Research Institute (J.M.W.), University of Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Mair","sequence":"additional","affiliation":[{"name":"Division of Neuroimaging Science, Edinburgh Imaging and Centre for Clinical Brain Sciences (J.M.W., G.M.), University of Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thompson G.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Center, University of Leicester, United Kingdom (T.G.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Chalmers","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine, University of New South Wales Sydney, Australia (Z.Z., S.Y., C.D., A.M., T.T.-Y., C.C., X.W., X.C., J.C., C.S.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China (Z.Z., J.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7248-4863","authenticated-orcid":false,"given":"Craig S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine, University of New South Wales Sydney, Australia (Z.Z., S.Y., C.D., A.M., T.T.-Y., C.C., X.W., X.C., J.C., C.S.A.)."},{"name":"Department of Neurology, Royal Prince Alfred Hospital, Sydney Health Partners, Australia (C.D., C.C., C.S.A.)."},{"name":"The George Institute China at Peking University Health Science Center, Beijing, China (C.S.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2265"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1515510"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2012.1310"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00012-5"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.015164"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.658906"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5431"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804355"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.119.028550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:48:52Z","timestamp":1715611732000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.119.028550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1161\/STROKEAHA.119.028550"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.119.028550","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2019-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}