{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:41:18Z","timestamp":1788932478976,"version":"build-2803163510"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>In acute spontaneous intracerebral hemorrhage, multiple hematoma expansion scores have been proposed for use in clinical trial environments. We performed a systematic scoping review to identify all existing hematoma expansion scores and describe their development, validation, and relative performance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Two reviewers searched MEDLINE, PUBMED, EMBASE, and CENTRAL (Cochrane Central Register of Controlled Trials) for studies that derived or validated a hematoma expansion prediction score in adults presenting with spontaneous intracerebral hemorrhage. A descriptive analysis of the extracted data was performed, focusing on score development techniques and predictive capabilities.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Of the 14\u2009434 records retrieved, 15 studies met inclusion criteria and 10 prediction scores were identified. Validation analysis using independent samples was performed in 9 studies on 5 scores. All derivation studies reported high performance with C statistics ranging from 0.72 to 0.93. In validation, the C-statistic range was broader with studies reporting 0.62 to 0.77. For every score, the risk of expansion increased with each point increase, although patients with high scores were rare.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>At present, 10 hematoma expansion scores have been developed, of which 5 have been externally validated. Real-world performance in validation studies was lower than performance in derivation studies. Data from the current literature are insufficient to support a meaningful meta-analysis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.028574","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T10:00:41Z","timestamp":1579687241000},"page":"1305-1308","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Evaluating Hematoma Expansion Scores in Acute Spontaneous Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-6853","authenticated-orcid":false,"given":"Vignan","family":"Yogendrakumar","sequence":"first","affiliation":[{"name":"From the Division of Neurology (V.Y., M.M., M.S., D.D.), University of Ottawa, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Moores","sequence":"additional","affiliation":[{"name":"From the Division of Neurology (V.Y., M.M., M.S., D.D.), University of Ottawa, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Sikora","sequence":"additional","affiliation":[{"name":"Health Sciences Library (L.S.), University of Ottawa, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Shamy","sequence":"additional","affiliation":[{"name":"From the Division of Neurology (V.Y., M.M., M.S., D.D.), University of Ottawa, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Ramsay","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute (T.R., D.F.), University of Ottawa, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Fergusson","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute (T.R., D.F.), University of Ottawa, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar","family":"Dowlatshahi","sequence":"additional","affiliation":[{"name":"From the Division of Neurology (V.Y., M.M., M.S., D.D.), University of Ottawa, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31033-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603460"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1161\/STROKEAHA.117.019541","article-title":"Unmet needs and challenges in clinical research of intracerebral hemorrhage.","volume":"49","author":"Hemorrhagic Stroke Academia Industry (HEADS) Roundtable Participants","year":"2018","unstructured":"Hemorrhagic Stroke Academia Industry (HEADS) Roundtable Participants. 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Guyatt, GH, Rennie, D, Meade, MO, Cook, DJ, eds. In: Users\u2019 Guides to the Medical Literature. A Manual For Evidence-Based Clinical Practice. 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