{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:09:20Z","timestamp":1787224160750,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>In ischemic stroke, inflammatory status may condition the development of collateral circulation. Here we assessed the relationship between systemic inflammatory biomarkers and collateral status in large vessel occlusion before mechanical thrombectomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>HIBISCUS-STROKE is a cohort study including acute ischemic stroke patients with large vessel occlusion treated with mechanical thrombectomy following admission magnetic resonance imaging. MMP-9 (matrix metalloproteinase-9) and MCP-1 (monocyte chemoattractant protein-1) were measured on blood sampling collected at admission. Collateral status was assessed on pretreatment Digital subtraction angiography and categorized into poor (Higashida score, 0\u20132) and good (Higashida score, 3\u20134). A multiple logistic regression model was performed to detect independent markers of good collateral status.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              One hundred and twenty-two patients were included, of them 71 patients (58.2%) had a good collateral status. In univariate analysis, low MMP-9 levels (\n              <jats:italic>P<\/jats:italic>\n              =0.01), high MCP-1 levels (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01), a low National Institute of Health Stroke Score (\n              <jats:italic>P<\/jats:italic>\n              =0.046), a high diastolic blood pressure (\n              <jats:italic>P<\/jats:italic>\n              =0.049), the absence of tandem occlusion (\n              <jats:italic>P<\/jats:italic>\n              =0.046), a high Alberta Stroke Program Early CT Score (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) and a low volume on the diffusion-weighted imaging (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) were associated with good collateral status. Following multivariate analysis, low MMP-9 levels (\n              <jats:italic>P<\/jats:italic>\n              =0.02) and high MCP-1 levels (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) remained associated with good collateral status.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Low MMP-9 and high MCP-1 levels were associated with good pretreatment collateral status in patients with acute ischemic stroke with large vessel occlusion. These results might suggest a relationship between collateral status and inflammation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.029395","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T13:27:37Z","timestamp":1592400457000},"page":"2232-2235","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Matrix Metalloproteinase-9 and Monocyte Chemoattractant Protein-1 Are Associated With Collateral Status in Acute Ischemic Stroke With Large Vessel Occlusion"],"prefix":"10.1161","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9165-5763","authenticated-orcid":false,"given":"Laura","family":"Mechtouff","sequence":"first","affiliation":[{"name":"Stroke Department (L.M., L.D., E.O., T.-H.C., N.N.), Hospices Civils de Lyon, France."},{"name":"INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bochaton","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit (T.B.), Hospices Civils de Lyon, France."},{"name":"INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Paccalet","sequence":"additional","affiliation":[{"name":"INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Crola Da Silva","sequence":"additional","affiliation":[{"name":"INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Buisson","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center, INSERM 1407 (M.B., C.A., N.M., M.O.), Hospices Civils de Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Amaz","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center, INSERM 1407 (M.B., C.A., N.M., M.O.), Hospices Civils de Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Derex","sequence":"additional","affiliation":[{"name":"Stroke Department (L.M., L.D., E.O., T.-H.C., N.N.), Hospices Civils de Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Ong","sequence":"additional","affiliation":[{"name":"Stroke Department (L.M., L.D., E.O., T.-H.C., N.N.), Hospices Civils de Lyon, France."},{"name":"INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Berthezene","sequence":"additional","affiliation":[{"name":"Neuroradiology Department (Y.B., O.F.E.), Hospices Civils de Lyon, France."},{"name":"CREATIS, CNRS UMR 5220, INSERM U1044 (Y.B.), University Lyon 1, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer Faruk","family":"Eker","sequence":"additional","affiliation":[{"name":"Neuroradiology Department (Y.B., O.F.E.), Hospices Civils de Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Dufay","sequence":"additional","affiliation":[{"name":"NeuroBioTec, CRB (N.D.), Hospices Civils de Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Mewton","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center, INSERM 1407 (M.B., C.A., N.M., M.O.), Hospices Civils de Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Ovize","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center, INSERM 1407 (M.B., C.A., N.M., M.O.), Hospices Civils de Lyon, France."},{"name":"INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Hee","family":"Cho","sequence":"additional","affiliation":[{"name":"Stroke Department (L.M., L.D., E.O., T.-H.C., N.N.), Hospices Civils de Lyon, France."},{"name":"INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Nighoghossian","sequence":"additional","affiliation":[{"name":"Stroke Department (L.M., L.D., E.O., T.-H.C., N.N.), Hospices Civils de Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011788"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000086465.41263.06"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017673"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027062"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000141145.78900.44"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000082721.62796.09"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2007.22.5.5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12312"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x04vm571oa"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0008-6363(00)00243-1"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.11.4678"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.120.029395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:49:22Z","timestamp":1715611762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.120.029395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1161\/STROKEAHA.120.029395"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.120.029395","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2020-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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