{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:39:10Z","timestamp":1791589150278,"version":"4.3.4"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>Cardiac pathologies are the second most frequent risk factor (RF) in children with arterial ischemic stroke (AIS). This study aimed to analyze RFs for AIS in children with cardiac disease and cardiac intervention.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Data were drawn from the Swiss Neuropediatric Stroke Registry. Patients with cardiac disease and postprocedural AIS registered from 2000 until 2015 were analyzed for the cause of cardiac disease and for potential RFs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Forty-seven out of 78 children with cardiac disease had a cardiac intervention. Of these, 36 presented a postprocedural AIS. Median time from cardiac intervention to symptom onset was 4 days (interquartile range, 2\u20138.5); time to diagnosis of AIS was 2 days (interquartile range, 0\u20135.8). Main RFs for postprocedural AIS were hypotension, prosthetic cardiac material, right-to-left shunt, arrhythmias, low cardiac output, and infections.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In children with postprocedural AIS, time to diagnosis was delayed. Most patients presented multiple potentially modifiable RFs as hemodynamic alterations and infections.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.029447","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T09:00:59Z","timestamp":1597827659000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Risk Factors for Postprocedural Arterial Ischemic Stroke in Children With Cardiac Disease"],"prefix":"10.1161","volume":"51","author":[{"given":"Bettina C.","family":"Henzi","sequence":"first","affiliation":[{"name":"Division of Child Neurology, Department of Pediatrics (B.C.H., M.R., M.S.), University Children\u2019s Hospital Bern, University of Bern, Switzerland."},{"name":"Department of Pediatric Neurology and Developmental Medicine, University of Basel, Children\u2019s Hospital Basel, Switzerland (B.C.H., A.N.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Brotschi","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Neonatal Intensive Care (B.B.), University Children\u2019s Hospital Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1358-3535","authenticated-orcid":true,"given":"Christian","family":"Balmer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology (C.B.), University Children\u2019s Hospital Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Hennig","sequence":"additional","affiliation":[{"name":"Division of Pediatric Intensive Care (B.H.), University Children\u2019s Hospital Bern, University of Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9760-9220","authenticated-orcid":true,"given":"Peter","family":"Rimensberger","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics, University Hospital of Geneva, Switzerland (P.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-3396","authenticated-orcid":true,"given":"Marie-H\u00e9l\u00e8ne","family":"Perez","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Department of Pediatrics, University Hospital of Lausanne, Switzerland (M.-H.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Pfammatter","sequence":"additional","affiliation":[{"name":"Center for Congenital Heart Disease, Departments of Cardiology and Cardiac Surgery, University Hospital of Bern, Switzerland (J.-P.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1841-0927","authenticated-orcid":true,"given":"Maurice","family":"Beghetti","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Unit, University Children\u2019s Hospital HUG, Pulmonary Hypertension Program HUG, Centre Universitaire Romand de Cardiologie et Chirurgie Cardiaque P\u00e9diatrique (CURCCCP), University of Geneva, Switzerland (M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Sekarski","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Unit, Department of Pediatrics, Centre Universitaire Romand de Cardiologie et Chirurgie Cardiaque Pediatrique (CURCCCP) (N.S.), Lausanne University Hospital, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre N.","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Developmental Medicine, University of Basel, Children\u2019s Hospital Basel, Switzerland (B.C.H., A.N.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Fluss","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Geneva Children\u2019s Hospital, Switzerland (J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Faignart","sequence":"additional","affiliation":[{"name":"Pediatric Neurology, Centre Hospitalier Universitaire Vaudois (N.F.), Lausanne University Hospital, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Hackenberg","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology (A.H.), University Children\u2019s Hospital Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria","family":"Reg\u00e9nyi","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, Department of Pediatrics (B.C.H., M.R., M.S.), University Children\u2019s Hospital Bern, University of Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Steinlin","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, Department of Pediatrics (B.C.H., M.R., M.S.), University Children\u2019s Hospital Bern, University of Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3882-6417","authenticated-orcid":true,"given":"Maja I.","family":"Hug","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University of Basel Children\u2019s Hospital (UKBB), Switzerland 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