{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:15:47Z","timestamp":1793405747161,"version":"4.5.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>This study aimed to develop and validate a nomogram for predicting the risk of stroke recurrence among young adults after ischemic stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Patients aged between 18 and 49 years with first-ever ischemic stroke were selected from the Nanjing Stroke Registry Program. A stepwise Cox proportional hazards regression model was employed to develop the best-fit nomogram. The discrimination and calibration in the training and validation cohorts were used to evaluate the nomogram. All patients were classified into low-, intermediate-, and high-risk groups based on the risk scores generated from the nomogram.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              A total of 604 patients were enrolled in this study. Hypertension (hazard ratio [HR], 2.038 [95% CI, 1.504\u20133.942];\n              <jats:italic>P<\/jats:italic>\n              =0.034), diabetes mellitus (HR, 3.224 [95% CI, 1.848\u20135.624];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), smoking status (current smokers versus nonsmokers; HR, 2.491 [95% CI, 1.304\u20134.759];\n              <jats:italic>P<\/jats:italic>\n              =0.006), and stroke cause (small-vessel occlusion versus large-artery atherosclerosis; HR, 0.325 [95% CI, 0.109\u20130.976];\n              <jats:italic>P<\/jats:italic>\n              =0.045) were associated with recurrent stroke. Educational years (&gt;12 versus 0\u20136; HR, 0.070 [95% CI, 0.015\u20130.319];\n              <jats:italic>P<\/jats:italic>\n              =0.001) were inversely correlated with recurrent stroke. The nomogram was composed of these factors, and successfully stratified patients into low-, intermediate-, and high-risk groups (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The nomogram composed of hypertension, diabetes mellitus, smoking status, stroke cause, and education years may predict the risk of stroke recurrence among young adults after ischemic stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.029740","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T09:02:07Z","timestamp":1589187727000},"page":"1865-1867","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["A Nomogram for Predicting Stroke Recurrence Among Young Adults"],"prefix":"10.1161","volume":"51","author":[{"given":"Kang","family":"Yuan","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Jinling Hospital, Nanjing Medical University, China (K.Y., J.C., G.X., X.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Jinling Hospital, Nanjing Medical University, China (K.Y., J.C., G.X., X.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine, Stroke Center &amp; Department of Neurology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui (P.X.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jinling Hospital, Medical School of Nanjing University, China (X.Z., Y.X., H.W., G.X., X.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqun","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, China (X.G., M.W., G.X., X.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, China (X.G., M.W., G.X., X.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jinling Hospital, Medical School of Nanjing University, China (X.Z., Y.X., H.W., G.X., X.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jinling Hospital, Medical School of Nanjing University, China (X.Z., Y.X., H.W., G.X., X.L.)"},{"name":"Department of Neurology, The 80th Group Army Hospital of The People\u2019s Liberation Army, Weifang, China (H.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelin","family":"Xu","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Jinling Hospital, Nanjing Medical University, China (K.Y., J.C., G.X., X.L.)"},{"name":"Department of Neurology, Jinling Hospital, Medical School of Nanjing University, China (X.Z., Y.X., H.W., G.X., X.L.)"},{"name":"Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, China (X.G., M.W., G.X., X.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-9632","authenticated-orcid":false,"given":"Xinfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Jinling Hospital, Nanjing Medical University, China (K.Y., J.C., G.X., X.L.)"},{"name":"Department of Neurology, Jinling Hospital, Medical School of Nanjing University, China (X.Z., Y.X., H.W., G.X., X.L.)"},{"name":"Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, China (X.G., M.W., G.X., X.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a4a451"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17707138"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2015.4516"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000093241"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000302"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30186-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.047"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30233-3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.015643"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000455093"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.570010"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.120.029740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:23:19Z","timestamp":1715613799000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.120.029740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1161\/STROKEAHA.120.029740"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.120.029740","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"2019-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}