{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T14:26:01Z","timestamp":1747923961497,"version":"3.40.5"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>The optimal timing for starting oral anticoagulant after an ischemic stroke related to atrial fibrillation remains a challenge, mainly in patients treated with systemic thrombolysis or mechanical thrombectomy. We aimed at assessing the incidence of early recurrence and major bleeding in patients with acute ischemic stroke and atrial fibrillation treated with thrombolytic therapy and\/or thrombectomy, who then received oral anticoagulants for secondary prevention.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We combined the dataset of the RAF and the RAF-NOACs (Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With Non\u2013Vitamin K Oral Anticoagulants) studies, which were prospective observational studies carried out from January 2012 to March 2014 and April 2014 to June 2016, respectively. We included consecutive patients with acute ischemic stroke and atrial fibrillation treated with either vitamin K antagonists or nonvitamin K oral anticoagulants. Primary outcome was the composite of stroke, transient ischemic attack, symptomatic systemic embolism, symptomatic cerebral bleeding, and major extracerebral bleeding within 90 days from the inclusion. Treated-patients were propensity matched to untreated-patients in a 1:1 ratio after stratification by baseline clinical features.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A total of 2159 patients were included, 564 (26%) patients received acute reperfusion therapies. After the index event, 505 (90%) patients treated with acute reperfusion therapies and 1287 of 1595 (81%) patients untreated started oral anticoagulation. Timing of starting oral anticoagulant was similar in reperfusion-treated and untreated patients (median 7.5 versus 7.0 days, respectively). At 90 days, the primary study outcome occurred in 37 (7%) patients treated with reperfusion and in 146 (9%) untreated patients (odds ratio, 0.74 [95% CI, 0.50\u20131.07]). After propensity score matching, risk of primary outcome was comparable between the 2 groups (odds ratio, 1.06 [95% CI, 0.53\u20132.02]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Acute reperfusion treatment did not influence the risk of early recurrence and major bleeding in patients with atrial fibrillation\u2013related acute ischemic stroke, who started on oral anticoagulant.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.030143","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T09:00:47Z","timestamp":1594371647000},"page":"2347-2354","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Safety of Anticoagulation in Patients Treated With Urgent Reperfusion for Ischemic Stroke Related to Atrial Fibrillation"],"prefix":"10.1161","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8033-4945","authenticated-orcid":true,"given":"Michela","family":"Giustozzi","sequence":"first","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M. Giustozzi, M. Acciarresi, G.A., V.C., C.B., A.A., M.V., C.D., M.G.M., L.A.C., M.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Acciarresi","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M. Giustozzi, M. Acciarresi, G.A., V.C., C.B., A.A., M.V., C.D., M.G.M., L.A.C., M.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Agnelli","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M. Giustozzi, M. Acciarresi, G.A., V.C., C.B., A.A., M.V., C.D., M.G.M., L.A.C., M.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Caso","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M. Giustozzi, M. Acciarresi, G.A., V.C., C.B., A.A., M.V., C.D., M.G.M., L.A.C., M.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Bandini","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ospedale San Paolo, Savona, Italy (F.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Tsivgoulis","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Tennessee Health Science Center, Memphis (G.T.)."},{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, National &amp; KapodistrianUniversity of Athens, School of Medicine, Greece (G.T., C.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi","family":"Yaghi","sequence":"additional","affiliation":[{"name":"Division of Stroke and Cerebrovascular Diseases, Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI (S.Y., K.L.F., P.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"Furie","sequence":"additional","affiliation":[{"name":"Division of Stroke and Cerebrovascular Diseases, Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI (S.Y., K.L.F., P.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasanna","family":"Tadi","sequence":"additional","affiliation":[{"name":"Division of Stroke and Cerebrovascular Diseases, Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI (S.Y., K.L.F., P.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Becattini","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M. Giustozzi, M. Acciarresi, G.A., V.C., C.B., A.A., M.V., C.D., M.G.M., L.A.C., M.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialuisa","family":"Zedde","sequence":"additional","affiliation":[{"name":"Neurology Unit, Stroke Unit, Arcispedale Santa Maria Nuova, Azienda Unit\u00e0 Sanitaria Locale \u2013 IRCCS, Reggio Emilia, Italy (M.Z.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azmil H.","family":"Abdul-Rahim","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Psychology, University of Glasgow (A.H.A.-R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennedy R.","family":"Lees","sequence":"additional","affiliation":[{"name":"School of Medicine, Dentistry and Nursing, University of Glasgow (K.R.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Alberti","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M. Giustozzi, M. Acciarresi, G.A., V.C., C.B., A.A., M.V., C.D., M.G.M., L.A.C., M.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Venti","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M. Giustozzi, M. Acciarresi, G.A., V.C., C.B., A.A., M.V., C.D., M.G.M., L.A.C., M.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cataldo","family":"D\u2019Amore","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M. Giustozzi, M. Acciarresi, G.A., V.C., C.B., A.A., M.V., C.D., M.G.M., L.A.C., M.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Giulia Mosconi","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M. Giustozzi, M. Acciarresi, G.A., V.C., C.B., A.A., M.V., C.D., M.G.M., L.A.C., M.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovica","family":"Anna Cimini","sequence":"additional","affiliation":[{"name":"Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M. Giustozzi, M. Acciarresi, G.A., V.C., C.B., A.A., M.V., C.D., M.G.M., L.A.C., M.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Bovi","sequence":"additional","affiliation":[{"name":"SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, M. Cappellari)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Carletti","sequence":"additional","affiliation":[{"name":"SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, M. Cappellari)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Rigatelli","sequence":"additional","affiliation":[{"name":"Pronto Soccorso - Ospedale Borgo Trento, DAI emergenza e accettazione, AOUI Verona (A.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Cappellari","sequence":"additional","affiliation":[{"name":"SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, M. Cappellari)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Putaala","sequence":"additional","affiliation":[{"name":"Department of Neurology, Helsinki University Central Hospital, Finland (J.P., L.T., T. Tatlisumak)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa","family":"Tomppo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Helsinki University Central Hospital, Finland (J.P., L.T., T. Tatlisumak)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turgut","family":"Tatlisumak","sequence":"additional","affiliation":[{"name":"Department of Neurology, Helsinki University Central Hospital, Finland (J.P., L.T., T. Tatlisumak)."},{"name":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sweden (T. Tatlisumak)."},{"name":"Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden (T. Tatlisumak)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Marcheselli","sequence":"additional","affiliation":[{"name":"Neurologia d\u2019urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pezzini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Italy (A. Pezzini, L. Poli, A. Padovani)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loris","family":"Poli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Italy (A. Pezzini, L. Poli, A. Padovani)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Padovani","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Italy (A. Pezzini, L. Poli, A. Padovani)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vieri","family":"Vannucchi","sequence":"additional","affiliation":[{"name":"Internal Medicine, Santa Maria Nuova Hospital, Firenze, Italy (V. Vannucchi, L.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Il","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Lorenzini","sequence":"additional","affiliation":[{"name":"SC Medicina e Chirurgia d\u2019Accettazione e d\u2019Urgenza, Ospedale Lotti Pontedera, Azienda USL Toscana Nordovest (G.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Tassi","sequence":"additional","affiliation":[{"name":"Stroke Unit, AOU Senese, Siena, Italy (R.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Guideri","sequence":"additional","affiliation":[{"name":"Stroke Unit, Jazzolino Hospital, Vibo Valentia, Italy (F. Galati)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Acampa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Martini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Ntaios","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece (G.N., G.A., K.M., E.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Athanasakis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece (G.N., G.A., K.M., E.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Makaritsis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece (G.N., G.A., K.M., E.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstathia","family":"Karagkiozi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece (G.N., G.A., K.M., E.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Vadikolias","sequence":"additional","affiliation":[{"name":"Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (K.V.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrissoula","family":"Liantinioti","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, National &amp; KapodistrianUniversity of Athens, School of Medicine, Greece (G.T., C.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikaterini","family":"Theodorou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Halvatsiotis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Mumoli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ospedale Civile di Livorno, Italy (N.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Galati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Sacco","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of L\u2019Aquila, Avezzano Hospital, Italy (S.S., C.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Tiseo","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of L\u2019Aquila, Avezzano Hospital, Italy (S.S., C.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Corea","sequence":"additional","affiliation":[{"name":"UO Gravi Cerebrolesioni, San Giovanni Battista Hospital, Foligno (F.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Ageno","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Insubria University, Varese, Italy (W.A., M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Bellesini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Insubria University, Varese, Italy (W.A., M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Silvestrelli","sequence":"additional","affiliation":[{"name":"S.C. di Neurologia e S.S. di Stroke Unit, ASST di Mantova, Mantova, Italy (G.S., A. Ciccone, A.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Ciccone","sequence":"additional","affiliation":[{"name":"S.C. di Neurologia e S.S. di Stroke Unit, ASST di Mantova, Mantova, Italy (G.S., A. Ciccone, A.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Lanari","sequence":"additional","affiliation":[{"name":"S.C. di Neurologia e S.S. di Stroke Unit, ASST di Mantova, Mantova, Italy (G.S., A. Ciccone, A.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Scoditti","sequence":"additional","affiliation":[{"name":"Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licia","family":"Denti","sequence":"additional","affiliation":[{"name":"Stroke Unit - Dipartimento Geriatrico Riabilitativo \u2013 University of Parma, Italy (L.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelangelo","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Italy (M.M., E.F., L.U., G.O., N.G., A. Chiti)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Italy (M.M., E.F., L.U., G.O., N.G., A. Chiti)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Ulivi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Italy (M.M., E.F., L.U., G.O., N.G., A. Chiti)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Italy (M.M., E.F., L.U., G.O., N.G., A. Chiti)."},{"name":"Neurologia, Ospedale Apuano, Massa Carrara, Italy (G.O., M. Giuntini)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Giannini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Italy (M.M., E.F., L.U., G.O., N.G., A. Chiti)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Tassinari","sequence":"additional","affiliation":[{"name":"Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Li-gure (Savona), Italy (T. 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Neurologia Presidio Ospedaliero di Ravenna Azienda USL della Romagna, Italy (E.M.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriy","family":"Flomin","sequence":"additional","affiliation":[{"name":"Stroke and Neurorehabilitation Unit MC \u2018Universal Clinic \u2018Oberig\u2019 Kyiv, Ukraine (Y.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Pieroni","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences,, Sapienza University of Rome, Italy (D.T., F.L., A. Pieroni)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odysseas","family":"Kargiotis","sequence":"additional","affiliation":[{"name":"Stroke Unit, Metropolitan Hospital, Piraeus, Greece (O.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore","family":"Karapanayiotides","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, AHEPA University Hospital, Thessaloniki, Greece (T.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Monaco","sequence":"additional","affiliation":[{"name":"Stroke Unit, Ospedale Civico, Palermo, Italy (S. Monaco)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Maimone Baronello","sequence":"additional","affiliation":[{"name":"Stroke Unit, University of Debrecen, Hungary (M.M.B., L.C., L.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszl\u00f3","family":"Csiba","sequence":"additional","affiliation":[{"name":"Stroke Unit, University of Debrecen, Hungary (M.M.B., L.C., L.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilla","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Stroke Unit, University of Debrecen, Hungary (M.M.B., L.C., L.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Chiti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Italy (M.M., E.F., L.U., G.O., N.G., A. Chiti)."},{"name":"Stroke Unit, Department of Neurology, Sant\u2019Andrea Hospital, La Spezia, Italy (A. Chiti, E.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Giorli","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neurology, Sant\u2019Andrea Hospital, La Spezia, Italy (A. Chiti, E.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Del Sette","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Neurologia, Ospedale Galliera, Genoa, Italy (M.D.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Imberti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ospedale Civile di Piacenza, Italy (D.I., D.Z.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorjan","family":"Zabzuni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ospedale Civile di Piacenza, Italy (D.I., D.Z.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Doronin","sequence":"additional","affiliation":[{"name":"Municipal Budgetary Healthcare Institution of Novosibirsk. City Clinical Hospital # 1. Novosibirsk (Russia) at the Novosibirsk State Medical University (Russia) (B.D., V. 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