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Here, we nonsystematically reviewed candidate laboratory biomarkers for stroke and their relationships to racial disparities in stroke. Current evidence indicates that IL-6 (interleukin-6), a proinflammatory cytokine, mediates racial disparities in stroke through its association with traditional risk factors. Only one reviewed biomarker, Lp(a) (lipoprotein[a]), is a race-specific risk factor for stroke. Lp(a) is highly genetically determined and levels are substantially higher in Black than White people; clinical and pharmaceutical ramifications for stroke prevention remain uncertain. Other studied stroke risk biomarkers did not explain racial differences in stroke. More research on Lp(a) and other biological and genetic risk factors is needed to understand and mitigate racial disparities in stroke.<\/jats:p>","DOI":"10.1161\/strokeaha.120.030425","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T18:01:26Z","timestamp":1603735286000},"page":"3417-3424","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Identifying Genetic and Biological Determinants of Race-Ethnic Disparities in Stroke in the United States"],"prefix":"10.1161","volume":"51","author":[{"given":"Debora","family":"Kamin Mukaz","sequence":"first","affiliation":[{"name":"Department of Medicine, Vermont Center on Cardiovascular and Brain Health (D.K.M., N.A.Z., M.C.), Larner College of Medicine at the University of Vermont, Burlington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8824-4410","authenticated-orcid":true,"given":"Neil A.","family":"Zakai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vermont Center on Cardiovascular and Brain Health (D.K.M., N.A.Z., M.C.), Larner College of Medicine at the University of Vermont, Burlington."},{"name":"Department of Pathology and Laboratory Medicine (N.A.Z., M.C.), Larner College of Medicine at the University of Vermont, Burlington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Cruz-Flores","sequence":"additional","affiliation":[{"name":"Department of Neurology, Paul L. 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