{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:11:42Z","timestamp":1785222702699,"version":"3.55.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>Ischemic infarction of the corpus callosum is rare and infarction isolated to the corpus callosum alone rarer still, accounting for much &lt;1% of ischemic stroke in most stroke registries. About half of callosal infarctions affect the splenium.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>During a 2-week period, at the height of the coronavirus disease 2019 (COVID-19) pandemic in New York City, 4 patients at Montefiore Medical Center in the Bronx were found to have ischemic lesions of the splenium of the corpus callosum, 2 with infarction isolated to the corpus callosum.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>All patients tested positive for COVID-19 and 3 had prolonged periods of intubation. All had cardiovascular risk factors. Clinically, all presented with encephalopathy and had evidence of coagulopathy and raised inflammatory markers.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Infarction of the splenium of the corpus callosum is exceedingly rare and a cluster of such cases suggests COVID-19 as an inciting agent, with the mechanisms to be elucidated.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.030434","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T09:00:17Z","timestamp":1595235617000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Infarction of the Splenium of the Corpus Callosum in the Age of COVID-19"],"prefix":"10.1161","volume":"51","author":[{"given":"Steven A.","family":"Sparr","sequence":"first","affiliation":[{"name":"Saul R. Korey Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis L.","family":"Bieri","sequence":"additional","affiliation":[{"name":"Saul R. Korey Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9458039"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0720-048x(96)01155-2"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.59.3.238"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199612000-00001"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120409"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.24.1.35"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2012.05.013"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2017.18.4.710"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.02.012"},{"key":"e_1_3_5_11_2","first-page":"285","article-title":"Pure Alexia without hemianopia: mapping reading specific pathways in the brain (abstract).","volume":"34","author":"Sparr SA","year":"1993","unstructured":"Sparr, SA, Miller, AM. Pure Alexia without hemianopia: mapping reading specific pathways in the brain (abstract). Ann Neurol. 1993;34:285.","journal-title":"Ann Neurol"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493020923472"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000507666"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493020921664"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.031"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.120.030434","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:32:10Z","timestamp":1715614330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.120.030434"}},"subtitle":["A Snapshot in Time"],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1161\/STROKEAHA.120.030434"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.120.030434","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"2020-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}