{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:33:32Z","timestamp":1777480412788,"version":"3.51.4"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>We determined associations of physiological abnormalities (systolic blood pressure, glucose, and body temperature) and warfarin use with outcomes in spontaneous intracerebral hemorrhage.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Post hoc analyses of INTERACT2 (Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial) comparing systolic blood pressure control (&lt;140 versus &lt;180 mm Hg) in 2839 hypertensive patients with intracerebral hemorrhage (onset &lt;6 hours). Multivariable logistic regression defined associations of baseline scores assigned as 0 to 6 per 10 mm Hg systolic blood pressure increase (range, 150\u2013220 mm Hg) and 0 or 1 for serum glucose (\u22646.5 versus &gt;6.5 mmol\/L), body temperature (\u226437.5 \u00b0C versus &gt;37.5 \u00b0C), and warfarin use (no versus yes) and death or major disability (modified Rankin Scale scores 3\u20136 at 90 days).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Baseline score distribution was 0 (7.7%), 1 (15.6%), 2 (19.0%), 3 (19.1%), 4 (15.2%), 5 (11.6%), 6 (8.9%), and 7 (2.9%). After adjustment for baseline neurological severity and potential confounders, significant linear associations were evident for increasing (per point) score and death or major disability (odds ratio, 1.12 [95% CI, 1.07\u20131.17]), death (odds ratio, 1.15 [95% CI, 1.07\u20131.23]), and major disability (odds ratio, 1.10 [95% CI, 1.05\u20131.15]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Combination of abnormal physiological parameters and warfarin use is associated with poor outcomes in intracerebral hemorrhage. Effects of their early control is under investigation in INTERACT3 (Intensive Care Bundle With Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00716079.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.030435","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T10:54:02Z","timestamp":1610362442000},"page":"722-725","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Associations of an Abnormal Physiological Score With Outcomes in Acute Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"52","clinical-trial-number":[{"clinical-trial-number":"nct00716079","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Lili","family":"Song","sequence":"first","affiliation":[{"name":"The George Institute China, Peking University Health Science Center, Beijing (L. Song, L. Sun, C.S.A.)."},{"name":"George Institute for Global Health, Sydney, Australia (L. Song, X.W., M.O., X.C., H.A., C.D., R.I.L, J.C., C.S.A.)."},{"name":"Faculty of Medicine, University of New South Wales, Sydney, Australia (L. Song, X.W., M.O., X.C., C.D., J.C., C.S.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1684-7076","authenticated-orcid":true,"given":"Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, Sydney, Australia (L. Song, X.W., M.O., X.C., H.A., C.D., R.I.L, J.C., C.S.A.)."},{"name":"Faculty of Medicine, University of New South Wales, Sydney, Australia (L. Song, X.W., M.O., X.C., C.D., J.C., C.S.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7917-6858","authenticated-orcid":true,"given":"Menglu","family":"Ouyang","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, Sydney, Australia (L. Song, X.W., M.O., X.C., H.A., C.D., R.I.L, J.C., C.S.A.)."},{"name":"Faculty of Medicine, University of New South Wales, Sydney, Australia (L. Song, X.W., M.O., X.C., C.D., J.C., C.S.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingli","family":"Sun","sequence":"additional","affiliation":[{"name":"The George Institute China, Peking University Health Science Center, Beijing (L. Song, L. Sun, C.S.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8367-542X","authenticated-orcid":true,"given":"Xiaoying","family":"Chen","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, Sydney, Australia (L. Song, X.W., M.O., X.C., H.A., C.D., R.I.L, J.C., C.S.A.)."},{"name":"Faculty of Medicine, University of New South Wales, Sydney, Australia (L. Song, X.W., M.O., X.C., C.D., J.C., C.S.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2064-2014","authenticated-orcid":true,"given":"Hisatomi","family":"Arima","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, Sydney, Australia (L. Song, X.W., M.O., X.C., H.A., C.D., R.I.L, J.C., C.S.A.)."},{"name":"Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Japan (H.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Else C.","family":"Sandset","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neurology, Oslo University Hospital, Norway (E.C.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candice","family":"Delcourt","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, Sydney, Australia (L. Song, X.W., M.O., X.C., H.A., C.D., R.I.L, J.C., C.S.A.)."},{"name":"Faculty of Medicine, University of New South Wales, Sydney, Australia (L. Song, X.W., M.O., X.C., C.D., J.C., C.S.A.)."},{"name":"Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia (C.D., C.S.A.)."},{"name":"University of Sydney, Australia (C.D., R.I.L, J.C., C.S.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-1524","authenticated-orcid":true,"given":"Jiguang","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hypertension, Ruijin Hospital, China (J.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guofang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuzhou Central Hospital, Jiangsu, China (G.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thompson","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences and National Institute of Health Research Leicester Biomedical Research Centre, University of Leicester, United Kingdom (T.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-5679","authenticated-orcid":true,"given":"Richard I.","family":"Lindley","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, Sydney, Australia (L. Song, X.W., M.O., X.C., H.A., C.D., R.I.L, J.C., C.S.A.)."},{"name":"University of Sydney, Australia (C.D., R.I.L, J.C., C.S.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-0580","authenticated-orcid":true,"given":"John","family":"Chalmers","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, Sydney, Australia (L. Song, X.W., M.O., X.C., H.A., C.D., R.I.L, J.C., C.S.A.)."},{"name":"Faculty of Medicine, University of New South Wales, Sydney, Australia (L. Song, X.W., M.O., X.C., C.D., J.C., C.S.A.)."},{"name":"University of Sydney, Australia (C.D., R.I.L, J.C., C.S.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"The George Institute China, Peking University Health Science Center, Beijing (L. Song, L. Sun, C.S.A.)."},{"name":"George Institute for Global Health, Sydney, Australia (L. Song, X.W., M.O., X.C., H.A., C.D., R.I.L, J.C., C.S.A.)."},{"name":"Faculty of Medicine, University of New South Wales, Sydney, Australia (L. Song, X.W., M.O., X.C., C.D., J.C., C.S.A.)."},{"name":"Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia (C.D., C.S.A.)."},{"name":"University of Sydney, Australia (C.D., R.I.L, J.C., C.S.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the INTERACT2 Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61485-2"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-315346"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.02.018"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011627"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-012-9779-9"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-313246"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214609"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000105052.65787.35"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002056"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.019539"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.0846"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00110-1"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25546"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.120.030435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:02:47Z","timestamp":1715612567000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.120.030435"}},"subtitle":["INTERACT2 Study"],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1161\/STROKEAHA.120.030435"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.120.030435","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2020-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}