{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:15:55Z","timestamp":1791670555863,"version":"4.3.4"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>The red blood cell fatty acid composition objectively reflects the long-term dietary intake of several fatty acids. In patients undergoing carotid endarterectomy, we explored whether red blood cell status of selected fatty acids related to symptomatic carotid artery disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We included patients with symptomatic (n=22) and asymptomatic (n=23) carotid artery disease. We determined all-C18:1 trans, linoleic acid (LA, C18:2n6), alpha-linolenic acid (C18:3n3), and the omega-3 index (sum of eicosapentaenoic [C20:5n3] and docosahexaenoic [C22:6n3] acids) in both red blood cells and carotid plaque phospholipids by gas-chromatography.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              In a multivariate logistic regression analysis, we only observed a significant association for LA, whose red blood cell status was inversely related to symptomatic carotid artery disease (odds ratio, 0.116 [95% CI, 0.022\u20130.607],\n              <jats:italic>P<\/jats:italic>\n              =0.011, for each 1-SD increase). A similar result was observed for LA in carotid plaque phospholipids.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Cell membrane enrichment in LA, which reflects its intake, was inversely related to symptomatic carotid disease. This increases evidence supporting a favorable role of dietary LA in vascular health.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.030477","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T10:03:33Z","timestamp":1607076213000},"page":"703-706","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Linoleic Acid Status in Cell Membranes Inversely Relates to the Prevalence of Symptomatic Carotid Artery Disease"],"prefix":"10.1161","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6172-9845","authenticated-orcid":true,"given":"Iolanda","family":"L\u00e1zaro","sequence":"first","affiliation":[{"name":"CIBER Pathophysiology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain (I.L., M.C., A.-J.A., E.O., A.S.-V.)."},{"name":"IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain (I.L., A.S.-V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1895-5644","authenticated-orcid":true,"given":"Montserrat","family":"Cof\u00e1n","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (M.C., E.O., T.-M.F.-S., L.L.L., S.A., A.S.-V.)."},{"name":"CIBER Pathophysiology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain (I.L., M.C., A.-J.A., E.O., A.S.-V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-0903","authenticated-orcid":true,"given":"Antonio J.","family":"Amor","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain (A.S.-V.)."},{"name":"Endocrinology and Nutrition Department (A.-J.A., E.O.), at Hospital Cl\u00ednic de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2217-8905","authenticated-orcid":true,"given":"Emilio","family":"Ortega","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (M.C., E.O., T.-M.F.-S., L.L.L., S.A., A.S.-V.)."},{"name":"Barcelona\u03b2eta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain (A.S.-V.)."},{"name":"Endocrinology and Nutrition Department (A.-J.A., E.O.), at Hospital Cl\u00ednic de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania-Marisa","family":"Freitas-Simoes","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (M.C., E.O., T.-M.F.-S., L.L.L., S.A., A.S.-V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Llull","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (M.C., E.O., T.-M.F.-S., L.L.L., S.A., A.S.-V.)."},{"name":"Neuroscience Department-Comprehensive Stroke Center (L.L.L., S.A.), at Hospital Cl\u00ednic de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6838-6390","authenticated-orcid":true,"given":"Sergio","family":"Amaro","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (M.C., E.O., T.-M.F.-S., L.L.L., S.A., A.S.-V.)."},{"name":"Neuroscience Department-Comprehensive Stroke Center (L.L.L., S.A.), at Hospital Cl\u00ednic de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaspar","family":"Mestres","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery-Cardiovascular Institute (G.M., X.Y., V.R.) at Hospital Cl\u00ednic de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Yugueros","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery-Cardiovascular Institute (G.M., X.Y., V.R.) at Hospital Cl\u00ednic de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sanford School of Medicine, University of South Dakota and OmegaQuant Analytics, LLC; Sioux Falls, South Dakota (W.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Riambau","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery-Cardiovascular Institute (G.M., X.Y., V.R.) at Hospital Cl\u00ednic de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5038-2794","authenticated-orcid":true,"given":"Aleix","family":"Sala-Vila","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (M.C., E.O., T.-M.F.-S., L.L.L., S.A., A.S.-V.)."},{"name":"CIBER Pathophysiology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain (I.L., M.C., A.-J.A., E.O., A.S.-V.)."},{"name":"Barcelona\u03b2eta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain (A.S.-V.)."},{"name":"IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain (I.L., A.S.-V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006306"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2008.03.003"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038908"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013131"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.120.030477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:02:38Z","timestamp":1715612558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.120.030477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":4,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1161\/STROKEAHA.120.030477"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.120.030477","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2020-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}