{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:53:28Z","timestamp":1790142808770,"version":"4.0.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>Significant hemorrhage expansion (sHE) is a known predictor of poor outcome after an intracerebral hemorrhage (ICH) in adults but remains poorly reported in children. In a large inception cohort, we aimed to explore the prevalence of sHE, its associations with clinical outcomes, and its clinical-imaging predictors in children.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Children admitted between January 2000 and March 2020 at a quaternary care pediatric hospital were screened for inclusion. Sample was restricted to children with 2 computed tomography scans within 72 hours of ICH onset, and a minimal clinical follow-up of months. sHE was defined as an increase from baseline ICH volume by 6 cc or 33% on follow-up computed tomography. Clinical outcome was assessed at 12 months with the King\u2019s Outcome Scale for Childhood Head Injury score and defined as favorable for scores \u22655.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Fifty-two children met inclusion criteria, among which 8 (15%) demonstrated sHE, and 18 (34.6%) any degree of expansion. Children with sHE had more frequent coagulation disorders (25.0% versus 2.3%;\n              <jats:italic>P<\/jats:italic>\n              =0.022). After multivariable adjustment, only the presence of coagulation disorders at baseline remained independently associated with sHE (adjusted odds ratio, 14.4 [95% CI, 1.04\u2013217];\n              <jats:italic>P<\/jats:italic>\n              =0.048). sHE was independently associated with poor outcome (King\u2019s Outcome Scale for Childhood Head Injury &lt;5A, odds ratio, 5.77 [95% CI, 1.01\u201338.95];\n              <jats:italic>P<\/jats:italic>\n              =0.043).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>sHE is a frequent phenomenon after admission for a pediatric ICH and more so in children with coagulation defects. As sHE was strongly associated with poorer clinical outcomes, these data mandate a baseline coagulation work up and questions the need for protocolized repeat head computed tomography in children admitted for pediatric ICH.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.030592","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T10:54:02Z","timestamp":1610362442000},"page":"588-594","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Hemorrhage Expansion After Pediatric Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-9205","authenticated-orcid":true,"given":"Gregoire","family":"Boulouis","sequence":"first","affiliation":[{"name":"GHU Paris Psychiatrie et Neurosciences, Hospitalier Sainte Anne, Service d\u2019imagerie Morphologique et Fonctionnelle, Institut de Psychiatrie et Neurosciences de Paris, Unit\u00e9 mixte de recherche S1266, Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, Universit\u00e9 de Paris, Paris, France (G.B., J.-F.H., B.K., F.G., L.G., O.N.)."},{"name":"Pediatric Radiology Department (G.B., J.-F.H., B.K., F.G., Q.A., L.G., N.B., O.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0225-7876","authenticated-orcid":true,"given":"Jean-Fran\u00e7ois","family":"Hak","sequence":"additional","affiliation":[{"name":"GHU Paris Psychiatrie et Neurosciences, Hospitalier Sainte Anne, Service d\u2019imagerie Morphologique et Fonctionnelle, Institut de Psychiatrie et Neurosciences de Paris, Unit\u00e9 mixte de recherche S1266, Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, Universit\u00e9 de Paris, Paris, France (G.B., J.-F.H., B.K., F.G., L.G., O.N.)."},{"name":"Pediatric Radiology Department (G.B., J.-F.H., B.K., F.G., Q.A., L.G., N.B., O.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0642-3955","authenticated-orcid":true,"given":"Basile","family":"Kerleroux","sequence":"additional","affiliation":[{"name":"GHU Paris Psychiatrie et Neurosciences, Hospitalier Sainte Anne, Service d\u2019imagerie Morphologique et Fonctionnelle, Institut de Psychiatrie et Neurosciences de Paris, Unit\u00e9 mixte de recherche S1266, Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, Universit\u00e9 de Paris, Paris, France (G.B., J.-F.H., B.K., F.G., L.G., O.N.)."},{"name":"Pediatric Radiology Department (G.B., J.-F.H., B.K., F.G., Q.A., L.G., N.B., O.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1143-2987","authenticated-orcid":true,"given":"Sandro","family":"Benichi","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery Department (S.B. S.S., M.B., T.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Stricker","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery Department (S.B. S.S., M.B., T.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Gariel","sequence":"additional","affiliation":[{"name":"GHU Paris Psychiatrie et Neurosciences, Hospitalier Sainte Anne, Service d\u2019imagerie Morphologique et Fonctionnelle, Institut de Psychiatrie et Neurosciences de Paris, Unit\u00e9 mixte de recherche S1266, Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, Universit\u00e9 de Paris, Paris, France (G.B., J.-F.H., B.K., F.G., L.G., O.N.)."},{"name":"Pediatric Radiology Department (G.B., J.-F.H., B.K., F.G., Q.A., L.G., N.B., O.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0958-7552","authenticated-orcid":true,"given":"Quentin","family":"Alias","sequence":"additional","affiliation":[{"name":"Pediatric Radiology Department (G.B., J.-F.H., B.K., F.G., Q.A., L.G., N.B., O.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bourgeois","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery Department (S.B. S.S., M.B., T.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-6631","authenticated-orcid":true,"given":"Philippe","family":"Meyer","sequence":"additional","affiliation":[{"name":"Pediatric Surgical ICU (P.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoelle","family":"Kossorotoff","sequence":"additional","affiliation":[{"name":"French Center for Pediatric Stroke (M.K., T.B., O.N.)."},{"name":"Pediatric Neurology Department (M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5000-4921","authenticated-orcid":true,"given":"Lorenzo","family":"Garzelli","sequence":"additional","affiliation":[{"name":"GHU Paris Psychiatrie et Neurosciences, Hospitalier Sainte Anne, Service d\u2019imagerie Morphologique et Fonctionnelle, Institut de Psychiatrie et Neurosciences de Paris, Unit\u00e9 mixte de recherche S1266, Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, Universit\u00e9 de Paris, Paris, France (G.B., J.-F.H., B.K., F.G., L.G., O.N.)."},{"name":"Pediatric Radiology Department (G.B., J.-F.H., B.K., F.G., Q.A., L.G., N.B., O.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3326-2811","authenticated-orcid":true,"given":"Nicolas","family":"Garcelon","sequence":"additional","affiliation":[{"name":"INSERM UMR1163, Imagine Institute, Data Science Platform, Paris-Descartes University, France (N.G., N.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Boddaert","sequence":"additional","affiliation":[{"name":"Pediatric Radiology Department (G.B., J.-F.H., B.K., F.G., Q.A., L.G., N.B., O.N.)."},{"name":"Pediatric Neurology Department (M.K.)."},{"name":"INSERM UMR1163, Imagine Institute, Data Science Platform, Paris-Descartes University, France (N.G., N.B.)."},{"name":"H\u00f4pital Necker Enfants Malades, Assistance Publique \u2013 Hopitaux de Paris (AP-HP), Universit\u00e9 de Paris, Paris, France (N.B.)."},{"name":"INSERM UMR 1000, Paris, France (N.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-1155","authenticated-orcid":true,"given":"Andrea","family":"Morotti","sequence":"additional","affiliation":[{"name":"ASST Valcamonica, Ospedale di Esine, UOSD Neurologia, Esine, Italy (A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Blauwblomme","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery Department (S.B. S.S., M.B., T.B.)."},{"name":"French Center for Pediatric Stroke (M.K., T.B., O.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Naggara","sequence":"additional","affiliation":[{"name":"GHU Paris Psychiatrie et Neurosciences, Hospitalier Sainte Anne, Service d\u2019imagerie Morphologique et Fonctionnelle, Institut de Psychiatrie et Neurosciences de Paris, Unit\u00e9 mixte de recherche S1266, Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, Universit\u00e9 de Paris, Paris, France (G.B., J.-F.H., B.K., F.G., L.G., O.N.)."},{"name":"Pediatric Radiology Department (G.B., J.-F.H., B.K., F.G., Q.A., L.G., N.B., O.N.)."},{"name":"French Center for Pediatric Stroke (M.K., T.B., O.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025783"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5433"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.1218"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.4672"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017170152"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.2619"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25563"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.02061.x"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60829-0"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-011-9538-3"},{"key":"e_1_3_5_13_2","first-page":"34","article-title":"Interpretation and implementation of intensive blood pressure reduction in acute cerebral hemorrhage trial (INTERACT II).","volume":"7","author":"Qureshi AI","year":"2014","unstructured":"Qureshi, AI, Palesch, YY, Martin, R, Toyoda, K, Yamamoto, H, Wang, Y, Wang, Y, Hsu, CY, Yoon, BW, Steiner, T, et al. Interpretation and implementation of intensive blood pressure reduction in acute cerebral hemorrhage trial (INTERACT II). J Vasc Interv Neurol. 2014;7:34\u201340.","journal-title":"J Vasc Interv Neurol"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0184-4"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4039"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e3181fa7049"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.120.030592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:02:12Z","timestamp":1715612532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.120.030592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1161\/STROKEAHA.120.030592"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.120.030592","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2020-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}