{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:41:14Z","timestamp":1770223274455,"version":"3.49.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>In December 2019, an outbreak of severe acute respiratory syndrome coronavirus causing coronavirus disease 2019 (COVID-19) occurred in China, and evolved into a worldwide pandemic. It remains unclear whether the history of cerebrovascular disease is associated with in-hospital death in patients with COVID-19.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We conducted a retrospective, multicenter cohort study at Mount Sinai Health System in New York City. Using our institutional data warehouse, we identified all adult patients who were admitted to the hospital between March 1, 2020 and May 1, 2020 and had a positive nasopharyngeal swab polymerase chain reaction test for severe acute respiratory syndrome coronavirus in the emergency department. Using our institutional electronic health record, we extracted clinical characteristics of the cohort, including age, sex, and comorbidities. Using multivariable logistic regression to control for medical comorbidities, we modeled the relationship between history of stroke and all-cause, in-hospital death.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              We identified 3248 patients, of whom 387 (11.9%) had a history of stroke. Compared with patients without history of stroke, patients with a history of stroke were significantly older, and were significantly more likely to have a history of all medical comorbidities except for obesity, which was more prevalent in patients without a history of stroke. Compared with patients without history of stroke, patients with a history of stroke had higher in-hospital death rates during the study period (48.6% versus 31.7%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). In the multivariable analysis, history of stroke (adjusted odds ratio, 1.28 [95% CI, 1.01\u20131.63]) was significantly associated with in-hospital death.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>We found that history of stroke was associated with in-hospital death among hospitalized patients with COVID-19. Further studies should confirm these results.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.030685","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T09:00:20Z","timestamp":1597050020000},"page":"3112-3114","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["History of Stroke Is Independently Associated With In-Hospital Death in Patients With COVID-19"],"prefix":"10.1161","volume":"51","author":[{"given":"Benjamin R.","family":"Kummer","sequence":"first","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York. (B.R.K., L.K.S., M.S.D., N.J.)"},{"name":"Clinical Informatics, Mount Sinai Health System, New York (B.R.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4567-3108","authenticated-orcid":true,"given":"Eyal","family":"Klang","sequence":"additional","affiliation":[{"name":"Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York. (E.K., N.J.)"},{"name":"Department of Radiology, Sheba Medical Center, Ramat Gan, Israel (E.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura K.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York. (B.R.K., L.K.S., M.S.D., N.J.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandip S.","family":"Dhamoon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York. (B.R.K., L.K.S., M.S.D., N.J.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Jett\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York. (B.R.K., L.K.S., M.S.D., N.J.)"},{"name":"Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York. (E.K., N.J.)"},{"name":"Division of Health Outcomes and Knowledge Translation Research, Department of Neurology, Icahn School of Medicine at Mount Sinai, New York. (N.J.)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","unstructured":"Johns Hopkins University. COVID19 Map. Johns Hopkins Coronavirus Resource Center. https:\/\/coronavirus.jhu.edu\/map.html. Accessed April 27 2020."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6775"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493020921664"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2004500"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5394"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.04.021"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14849"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1710018"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.120.030685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:09:33Z","timestamp":1715612973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.120.030685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":9,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1161\/STROKEAHA.120.030685"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.120.030685","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"2020-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}