{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:12:10Z","timestamp":1793153530005,"version":"4.5.0"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>Whether bridging therapy (intravenous thrombolysis [IVT] followed by mechanical thrombectomy) is superior to IVT alone in minor stroke with basilar artery occlusion remains uncertain.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Multicentric retrospective observational study of consecutive minor stroke patients (National Institutes of Health Stroke Scale score \u22645) with basilar artery occlusion intended for IVT alone or bridging therapy. Propensity-score weighting was used to reduce baseline between-groups differences, and residual imbalance was addressed through adjusted logistic regression, with excellent outcome (3-month modified Rankin Scale score 0\u20131) as the dependent variable.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Fifty-seven patients were included (28 and 29 in the bridging therapy and IVT alone groups, respectively). Following propensity-score weighting, the distribution of baseline clinical and radiological variables was similar across the 2 patient groups, except age, posterior circulation Alberta Stroke Program Early CT Score, history of hypertension and smoking, and onset-to-IVT time. Compared with IVT alone, bridging therapy was associated with excellent outcome (adjusted odds ratio=3.37 [95% CI, 1.13\u201310.03];\n              <jats:italic>P<\/jats:italic>\n              =0.03). No patient experienced symptomatic intracranial hemorrhage.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Our results suggest that bridging therapy may be superior to IVT alone in minor stroke with basilar artery occlusion.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.030992","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T10:49:48Z","timestamp":1610016588000},"page":"699-702","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Intended Bridging Therapy or Intravenous Thrombolysis Alone in Minor Stroke With Basilar Artery Occlusion"],"prefix":"10.1161","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2134-0691","authenticated-orcid":true,"given":"Pierre","family":"Seners","sequence":"first","affiliation":[{"name":"Neurology Department, Ste Anne 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Department, CHRU Nancy, France (S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Niclot","sequence":"additional","affiliation":[{"name":"Neurology Department, Ren\u00e9 Dubos Hospital, Pontoise, France (P.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-2588","authenticated-orcid":true,"given":"Jean-Claude","family":"Baron","sequence":"additional","affiliation":[{"name":"Neurology Department, Ste Anne Hospital, INSERM U1266, FHU Neurovasc, Paris, France (P.S., J.-C.B., G.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-4095","authenticated-orcid":true,"given":"Guillaume","family":"Turc","sequence":"additional","affiliation":[{"name":"Neurology Department, Ste Anne Hospital, INSERM U1266, FHU Neurovasc, Paris, France (P.S., J.-C.B., 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randomized acute stroke trial of endovascular therapy in acute basilar artery occlusion.","author":"Schonewille W","year":"2020","unstructured":"Schonewille, W. A randomized acute stroke trial of endovascular therapy in acute basilar artery occlusion. ESOC. 2020. https:\/\/eso-wso-conference.org\/eso-wso-may-webinar\/. Accessed September 2, 2020.","journal-title":"ESOC"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014568"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70173-5"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25756"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.021106"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000369121"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.120.030992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:02:37Z","timestamp":1715612557000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.120.030992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1161\/STROKEAHA.120.030992"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.120.030992","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2020-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}