{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:02:47Z","timestamp":1785769367146,"version":"3.56.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>Perinatal stroke is a common cause of life-long neurobehavioral compromise. Mesenchymal stromal cells (MSCs) and EPO (erythropoietin) have each demonstrated short-term benefit with delayed administration after stroke, and combination therapy may provide the most benefit. The purpose of this study is to determine the long-term histological and functional efficacy of enhanced, intranasal stem cell therapy (MSC preexposed to EPO) compared with standard MSC or multidose systemic EPO.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Transient middle cerebral artery occlusion or sham surgery was performed in postnatal day (P) 10 Sprague-Dawley rats, who were treated with single-dose intranasal MSC, MSC preexposed to EPO (MSC\/EPO), multidose systemic EPO (EPO3; 1000 u\/kg per dose\u00d73 every 72 hours), or cell-conditioned media on P13 (day 3 [P13\u2013P19] for EPO), or on P17 (day 7 [P17\u2013P23] for EPO). At 2 months of age, animals underwent novel object recognition, cylinder rearing, and open field testing to assess recognition memory, sensorimotor function, and anxiety in adulthood.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>MSC, MSC\/EPO, and EPO3 improved brain volume when administered at 3 or 7 days after middle cerebral artery occlusion. MSC\/EPO also enhanced long-term recognition memory with either day 3 or day 7 treatment, but EPO3 had the most long-term benefit, improving recognition memory and exploratory behavior and reducing anxiety.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>These data suggest that single-dose MSC\/EPO and multidose systemic EPO improve long-term neurobehavioral outcomes even when administration is delayed, although EPO was the most effective treatment overall. It is possible that EPO represents a final common pathway for improved long-term repair, although the specific mechanisms remain to be determined.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.031191","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T10:00:29Z","timestamp":1608631229000},"page":"284-293","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Enhanced Mesenchymal Stromal Cells or Erythropoietin Provide Long-Term Functional Benefit After Neonatal Stroke"],"prefix":"10.1161","volume":"52","author":[{"given":"Amara","family":"Larpthaveesarp","sequence":"first","affiliation":[{"name":"Department of Pediatrics (A.L., P.P., S.O., A.R., D.F., F.F.G.), University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praneeti","family":"Pathipati","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (A.L., P.P., S.O., A.R., D.F., F.F.G.), University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3633-1947","authenticated-orcid":true,"given":"Samuel","family":"Ostrin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (A.L., P.P., S.O., A.R., D.F., F.F.G.), University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Rajah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (A.L., P.P., S.O., A.R., D.F., F.F.G.), University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-9045","authenticated-orcid":true,"given":"Donna","family":"Ferriero","sequence":"additional","affiliation":[{"name":"Department of Neurology (D.F.), University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5893-4592","authenticated-orcid":true,"given":"Fernando F.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (A.L., P.P., S.O., A.R., D.F., F.F.G.), University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1520"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/fetalneonatal-2010-196451"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041996"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.07.001"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30173-1"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.59.6.824"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000279654"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07176.x"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20321"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000232558"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000104"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.04.006"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000326"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00207"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.06.086"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.4238\/2015.December.29.8"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2016.08.003"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368915X686887"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-0867-5"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091550"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-012-0221-6"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-0102(98)00096-0"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000105473"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.5115\/acb.2013.46.2.113"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.01.015"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181f1c289"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051253"},{"key":"e_1_3_5_29_2","first-page":"476","article-title":"The novel object recognition test in rodents: which are the essential methodological aspects.","author":"Moscardo E","year":"2012","unstructured":"Moscardo, E, Salvetti, B, Becchi, S, Bertini, G. 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