{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:34:38Z","timestamp":1791995678377,"version":"4.4.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose:<\/jats:title>\n                    <jats:p>A variety of definitions for minor stroke have been proposed. We aimed to compare the clinical characteristics and outcomes of minor stroke defined as the National Institutes of Health Stroke Scale (NIHSS) score \u22645 versus \u22643.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrieved acute ischemic stroke patients with NIHSS score \u22645 in the CSCA study (China Stroke Center Alliance) between August 2015 and 2019. In-hospital clinical outcomes including all-cause mortality, stroke, and myocardial infarction were compared between the NIHSS score \u22645 and NIHSS score \u22643 groups using absolute standardized differences (ASD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 1\u2009006\u2009798 patients were registered in the CSCA program from 1476 hospitals, 472\u2009352 patients had NIHSS score \u22645, of whom 356\u2009314 patients had NIHSS score \u22643. The in-hospital composite events of death, myocardial infarction, or recurrent stroke were not significantly different between the NIHSS score \u22645 and NIHSS score \u22643 groups (5.6% [26\u2009346\/472\u2009352] versus 5.2% [18\u2009682\/356\u2009314]; ASD, 1.8). The in-hospital all-cause mortality (0.1% [443\/472\u2009352] versus 0.1% [255\/356\u2009314]; ASD, &lt;0.01), recurrent ischemic stroke (5.3% [25\u2009026\/472\u2009352] versus 5.0% [17\u2009777\/356\u2009314]; ASD, 1.4), and hemorrhagic stroke (0.5% [2151\/472\u2009352] versus 0.4% [1475\/356\u2009314]; ASD, 1.5) were not significantly different between both the NIHSS score \u22645 and NIHSS score \u22643 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our large-scale study identified that minor stroke using NIHSS scores \u22645 and \u22643 as the definition was comparable with each other regarding in-hospital all-cause mortality, recurrent stroke, and hemorrhagic stroke. This observation may be useful for future comparison studies and clinical trial design.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.120.031329","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T14:56:12Z","timestamp":1613487372000},"page":"1253-1258","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Clinical Characteristics and In-Hospital Outcomes of Varying Definitions of Minor Stroke"],"prefix":"10.1161","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1353-2295","authenticated-orcid":true,"given":"Yunyun","family":"Xiong","sequence":"first","affiliation":[{"name":"Vascular Neurology, Department of Neurology (Y.X., X.-Q.Z., X.Y., C.W., Y.-L.W., Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (Y.X., H.G., X.-Q.Z., Y.-L.W., L.-P.L., Q.Z., Z.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1608-1856","authenticated-orcid":true,"given":"Hongqiu","family":"Gu","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (Y.X., H.G., X.-Q.Z., Y.-L.W., L.-P.L., Q.Z., Z.L., Y.W.)."},{"name":"National Center for Healthcare Quality Management in Neurological Diseases, Beijing (H.G., X.Y., C.W., Z.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8345-5147","authenticated-orcid":true,"given":"Xing-Quan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Vascular Neurology, Department of Neurology (Y.X., X.-Q.Z., X.Y., C.W., Y.-L.W., Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (Y.X., H.G., X.-Q.Z., Y.-L.W., L.-P.L., Q.Z., Z.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Vascular Neurology, Department of Neurology (Y.X., X.-Q.Z., X.Y., C.W., Y.-L.W., Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"National Center for Healthcare Quality Management in Neurological Diseases, Beijing (H.G., X.Y., C.W., Z.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Vascular Neurology, Department of Neurology (Y.X., X.-Q.Z., X.Y., C.W., Y.-L.W., Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"National Center for Healthcare Quality Management in Neurological Diseases, Beijing (H.G., X.Y., C.W., Z.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2725-2788","authenticated-orcid":true,"given":"Yi-Long","family":"Wang","sequence":"additional","affiliation":[{"name":"Vascular Neurology, Department of Neurology (Y.X., X.-Q.Z., X.Y., C.W., Y.-L.W., Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (Y.X., H.G., X.-Q.Z., Y.-L.W., L.-P.L., Q.Z., Z.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2943-055X","authenticated-orcid":true,"given":"Li-Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Neuro-Intensive Care Unit, Department of Neurology (L.-P.L.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (Y.X., H.G., X.-Q.Z., Y.-L.W., L.-P.L., Q.Z., Z.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (Y.X., H.G., X.-Q.Z., Y.-L.W., L.-P.L., Q.Z., Z.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6116-475X","authenticated-orcid":true,"given":"Marc","family":"Fisher","sequence":"additional","affiliation":[{"name":"Stroke Division, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (M.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4713-5418","authenticated-orcid":true,"given":"Zixiao","family":"Li","sequence":"additional","affiliation":[{"name":"Vascular Neurology, Department of Neurology (Y.X., X.-Q.Z., X.Y., C.W., Y.-L.W., Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"National Center for Healthcare Quality Management in Neurological Diseases, Beijing (H.G., X.Y., C.W., Z.L., Y.W.)."},{"name":"Center for Stroke, Beijing Institute for Brain Disorders, China (Z.L., Y.W.)."},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (Z.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-2341","authenticated-orcid":true,"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Vascular Neurology, Department of Neurology (Y.X., X.-Q.Z., X.Y., C.W., Y.-L.W., Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"National Center for Healthcare Quality Management in Neurological Diseases, Beijing (H.G., X.Y., C.W., Z.L., Y.W.)."},{"name":"Center for Stroke, Beijing Institute for Brain Disorders, China (Z.L., Y.W.)."},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (Z.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2007.00142.x"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.37991.635266.44"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1802712"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018045"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.572883"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008312"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.019341"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215340"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800410"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61448-2"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2018-000154"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7497.960"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.08.13"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2531"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002881"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.8496"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000211"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.120.031329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:24:05Z","timestamp":1762874645000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.120.031329"}},"subtitle":["From a Large-Scale Nation-Wide Longitudinal Registry"],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1161\/STROKEAHA.120.031329"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.120.031329","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"2020-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication 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