{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:12:04Z","timestamp":1758946324128,"version":"3.40.5"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>We assessed the outcomes of dabigatran versus aspirin in a prespecified subgroup analysis of East Asian patients with embolic stroke of undetermined source in the RE-SPECT ESUS trial (Randomized, Double-Blind, Evaluation in Secondary Stroke Prevention Comparing the Efficacy and Safety of the Oral Thrombin Inhibitor Dabigatran Etexilate Versus Acetylsalicylic Acid in Patients With Embolic Stroke of Undetermined Source).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Patients with a recent embolic stroke of undetermined source were randomized to dabigatran (150 or 110 mg BID) or aspirin (100 mg QD). The primary efficacy outcome was recurrent stroke; the primary safety outcome was major bleeding. The East Asia cohort was compared with patients from all other countries (non-East Asia cohort).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Overall, 988 of 5390 patients (18%) were randomized in East Asia. During a median follow-up of 18.8 months, there was no statistically significant difference in recurrent stroke (hazard ratio, 0.65 [95% CI, 0.41\u20131.03]) or major bleeding (hazard ratio, 1.04 [95% CI, 0.57\u20131.91]) in East Asian patients receiving dabigatran versus aspirin. Death from any cause occurred more often in the dabigatran versus the aspirin group (hazard ratio, 3.98 [95% CI, 1.32\u201312.01]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The treatment effect of dabigatran versus aspirin was consistent between cohorts, with no apparent superiority for dabigatran over aspirin in preventing recurrent stroke in patients with embolic stroke of undetermined source.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT02239120.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.031891","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T19:56:12Z","timestamp":1613505372000},"page":"1069-1073","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Dabigatran or Aspirin in East Asian Patients With Embolic Stroke of Undetermined Source"],"prefix":"10.1161","volume":"52","clinical-trial-number":[{"clinical-trial-number":"nct02239120","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6280-8190","authenticated-orcid":true,"given":"Shinichiro","family":"Uchiyama","sequence":"first","affiliation":[{"name":"Clinical Research Centre for Medicine, International University of Health and Welfare, Tokyo, Japan (S.U.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8346-9845","authenticated-orcid":true,"given":"Kazunori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan (K.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-981X","authenticated-orcid":true,"given":"Byung-Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hallym Neurological Institute, Hallym University College of Medicine, Seoul, South Korea (B.-C.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Wei","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taiwan (C.-W.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence Ka Sing","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin (L.K.S.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Grauer","sequence":"additional","affiliation":[{"name":"Clinical Operations Global, Boehringer Ingelheim Pharma GmbH K.G., Biberach, Germany (C.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Brueckmann","sequence":"additional","affiliation":[{"name":"Department of Cardiometabolic Medicine, Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany (M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Biostatistics and Data Sciences (A.T.), Nippon Boehringer Ingelheim Co, Ltd, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Urano","sequence":"additional","affiliation":[{"name":"Primary Care Medicine (Y.U.), Nippon Boehringer Ingelheim Co, Ltd, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8039-805X","authenticated-orcid":true,"given":"J. Donald","family":"Easton","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco (J.D.E.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the RE-SPECT ESUS Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70310-7"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000024"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2302"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70274-X"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-11-0191"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62343-0"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1813959"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-20-0563"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12630"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01860217"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw210"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.120.031891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:55:12Z","timestamp":1715612112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.120.031891"}},"subtitle":["RE-SPECT ESUS Subgroup Analysis"],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1161\/STROKEAHA.120.031891"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.120.031891","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"type":"print","value":"0039-2499"},{"type":"electronic","value":"1524-4628"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"2020-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}