{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:06:23Z","timestamp":1791497183041,"version":"4.3.4"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>Ipsilateral thalamic diaschisis (ITD) initially describes functional depression of the thalamus ipsilateral to a supratentorial lesion, but accumulating evidence has shown morphological changes also occur. Therefore, we aimed to characterize thalamic perfusion and diffusion related to ITD over time and their inter-relationships after middle cerebral artery infarction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Eighty-five patients with middle cerebral artery infarction who underwent diffusion kurtosis imaging and arterial spin labeling were retrospectively included. ITD was diagnosed as ipsilateral thalamic hypoperfusion present on \u22652 cerebral blood flow maps. The thalamic asymmetrical index was calculated as (ipsilateral value\u2212contralateral value)\/contralateral value\u00d7100%. Finally, the inter-relationships of thalamic perfusion and diffusion were analyzed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              ITD was present in 56\/85 patients (65.9%, ITD+). In ITD+ patients, larger abnormal perfusion volume, higher perfusion-infarct mismatch and lower rates of focal hyperperfusion were observed than ITD\u2212 patients. Infarction affecting the corona radiata were more frequent among ITD+ patients. Mean kurtosis were slightly but significantly increased within the ipsilateral thalamus compared with the contralateral one in ITD+ patients of subacute and chronic groups, while fractional anisotropy was significantly increased in subacute group but decreased in chronic group for both ITD+ and ITD\u2212 patients. Mean diffusivity was significantly increased in ITD+ patients of chronic group. Furthermore, the AI\n              <jats:sub>CBF<\/jats:sub>\n              was negatively and significantly correlated with AI\n              <jats:sub>MK<\/jats:sub>\n              and AI\n              <jats:sub>FA<\/jats:sub>\n              in ITD+ patients in subacute group, and AI\n              <jats:sub>MD<\/jats:sub>\n              , even after adjustment for abnormal perfusion volume and days from symptoms onset, in chronic group. ITD+ patients had significantly higher National Institutes of Health Stroke Scale and modified Rankin Scale scores at admission and discharge and also showed a trend to independent association with clinical outcome at discharge.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The combination of arterial spin labeling and diffusion kurtosis imaging can reveal early, time-specific thalamic perfusion and diffusion changes after middle cerebral artery infarction. ITD-related hypoperfusion was significantly correlated with underlying microstructural alterations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.032464","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T09:01:05Z","timestamp":1620723665000},"page":"2319-2327","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Characterizing Diaschisis-Related Thalamic Perfusion and Diffusion After Middle Cerebral Artery Infarction"],"prefix":"10.1161","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-6187","authenticated-orcid":true,"given":"Cong","family":"Xia","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-7392","authenticated-orcid":true,"given":"Jiaying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6716-6350","authenticated-orcid":true,"given":"Chunqiang","family":"Lu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuancheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5463-8008","authenticated-orcid":true,"given":"Tianyu","family":"Tang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cai","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-7865","authenticated-orcid":true,"given":"Shenghong","family":"Ju","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0067-17.2017"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102329"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.020698"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.24.1.84"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390408"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.112012499"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx114"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.632448"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000039406.64644.cb"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600054"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.041012"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016150789"},{"key":"e_1_3_5_14_2","first-page":"818456","article-title":"Arterial spin labeling (ASL) fMRI: advantages, theoretical constrains and experimental challenges in neurosciences.","volume":"2012","author":"Borogovac A","year":"2012","unstructured":"Borogovac, A, Asllani, I. 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