{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:31:56Z","timestamp":1790317916194,"version":"4.1.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, many countries have introduced strict hygiene measures of social distancing to prevent further spreading of the disease. This may have led to a decreased presentation to hospital of patients with acute medical conditions and time-dependent management, such as stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We conducted a nationwide cohort study using administrative database of all hospitalized patients with main diagnosis of acute ischemic stroke (AIS), transient ischemic attack, or intracerebral hemorrhage. Data from a total of 1463 hospitals in Germany were included. We compared case numbers and treatment characteristics of pandemic (March 16 to May 15, 2020) and prepandemic (January 16 to March 15, 2020) cases and also with corresponding time period in 2019.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              We identified a strong decline for hospitalization of AIS (\u221217.4%), transient ischemic attack (\u221222.9%), and intracerebral hemorrhage (\u221215.8%) patients during the pandemic compared with prepandemic period. IVT rate in patients with AIS was comparable (prepandemic versus pandemic: 16.4% versus 16.6%,\n              <jats:italic>P<\/jats:italic>\n              =0.448), whereas mechanical thrombectomy rate was significantly higher during the pandemic (8.1% versus 7.7%,\n              <jats:italic>P<\/jats:italic>\n              =0.044). In-hospital mortality was significantly increased in patients with AIS during the pandemic period (8.1% versus 7.6%,\n              <jats:italic>P<\/jats:italic>\n              =0.006).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Besides a massive decrease in absolute case numbers, our data suggest that patients with AIS who did seek acute care during the pandemic, continued to receive acute recanalization treatment in Germany.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.120.033160","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T10:02:10Z","timestamp":1608804130000},"page":"716-721","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["Analysis of Nationwide Stroke Patient Care in Times of COVID-19 Pandemic in Germany"],"prefix":"10.1161","volume":"52","author":[{"given":"Daniel","family":"Richter","sequence":"first","affiliation":[{"name":"Department of Neurology, St Josef-Hospital Bochum (D.R., D.B., C.K.), Ruhr University Bochum, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Eyding","sequence":"additional","affiliation":[{"name":"Medical Faculty (J.E., R.W., C.K.), Ruhr University Bochum, Germany."},{"name":"Department of Neurology, Gemeinschaftskrankenhaus Herdecke, Germany (J.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5486-7027","authenticated-orcid":true,"given":"Ralph","family":"Weber","sequence":"additional","affiliation":[{"name":"Medical Faculty (J.E., R.W., C.K.), Ruhr University Bochum, Germany."},{"name":"Department of Neurology, Alfried Krupp Krankenhaus Essen, Germany (R.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Bartig","sequence":"additional","affiliation":[{"name":"Department of Neurology, St Josef-Hospital Bochum (D.R., D.B., C.K.), Ruhr University Bochum, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Grau","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum der Stadt Ludwigshafen, Germany (A.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Hacke","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Heidelberg, Germany (W.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2965-4051","authenticated-orcid":true,"given":"Christos","family":"Krogias","sequence":"additional","affiliation":[{"name":"Department of Neurology, St Josef-Hospital Bochum (D.R., D.B., C.K.), Ruhr University Bochum, Germany."},{"name":"Medical Faculty (J.E., R.W., C.K.), Ruhr University Bochum, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","unstructured":"Deutsche Gesellschaft f\u00fcr Neurologie. Das Phaenomen der leeren Stroke-units waehrend der Corona-Krise. https:\/\/dgn.org\/neuronews\/journal_club\/phaenomen-der-leeren-stroke-units-waehrend-der-corona-krise-profchristian-gerloff-sprach-dazu-in-ndr-visite\/. Accessed October 10 2020."},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000507666"},{"key":"e_1_3_5_4_2","first-page":"1","article-title":"Low stroke incidence in the TEMPiS telestroke network during COVID-19 pandemic-effect of lockdown on thrombolysis and thrombectomy.","volume":"0","author":"Schlachetzki F","year":"2020","unstructured":"Schlachetzki, F, Theek, C, Hubert, ND, Kilic, M, Haberl, RL, Linker, RA, Hubert, GJ. Low stroke incidence in the TEMPiS telestroke network during COVID-19 pandemic-effect of lockdown on thrombolysis and thrombectomy. J Telemed Telecare. 2020;0:1\u20137.","journal-title":"J Telemed Telecare"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030225"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14316"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030105"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031099"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030331"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030395"},{"key":"e_1_3_5_11_2","unstructured":"American College of Emergency Physicians. American College of Emergency Physicians COVID-19. https:\/\/www.emergencyphysicians.org\/globalassets\/emphysicians\/all-pdfs\/acep-mc-Covid19-april-poll-analysis.pdf. Accessed August 19 2020."},{"key":"e_1_3_5_12_2","unstructured":"Deutsche Interdisziplin\u00e4re Vereinigung f\u00fcr Intensiv- und Notfallmedizin. DIVI Intensivregister. https:\/\/www.intensivregister.de\/#\/intensivregister?tab=laendertabelle. Accessed October 13 2020."},{"key":"e_1_3_5_13_2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s42466-019-0010-8","article-title":"Distribution and evolution of acute interventional ischemic stroke treatment in Germany from 2010 to 2016.","volume":"1","author":"Weber R","year":"2019","unstructured":"Weber, R, Eyding, J, Kitzrow, M, Bartig, D, Weimar, C, Hacke, W, Krogias, C. Distribution and evolution of acute interventional ischemic stroke treatment in Germany from 2010 to 2016. Neurol Res Pract. 2019;1:4.","journal-title":"Neurol Res Pract"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14375"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031293"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00115-020-00989-8"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.120.033160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:00:53Z","timestamp":1715612453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.120.033160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1161\/STROKEAHA.120.033160"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.120.033160","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2020-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}