{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T05:51:30Z","timestamp":1791697890712,"version":"4.3.4"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose:<\/jats:title>\n                    <jats:p>Hypertensive disorders of pregnancy (HDP) comprise 4 subtypes. Previous studies have not investigated the relationship between stroke risk, different HDP subtypes, and follow-up time, which was the purpose of this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data of 17\u2009588 women aged 18 to 45 years who had a history of HDP in Taiwan from 2000 to 2017 was retrospectively reviewed. After matching with confounders, 13\u2009617 HDP women and 54\u2009468 non-HDP women were recruited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      HDP women had an adjusted hazard ratio (aHR) of 1.71 (95% CI, 1.46\u22122.00) for stroke, and 1.60 (1.35\u22121.89) and 2.98 (2.13\u22124.18) for ischemic and hemorrhagic stroke, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001 for all). The overall stroke risk in the HDP group was still 2.04 times 10 to 15 years after childbirth (1.47\u22122.83,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Although the risks of both ischemic and hemorrhagic stroke persisted, their risk time trends were different. The risk of ischemic stroke reached peak during 1 to 3 years after childbirth with an aHR of 2.14 (1.36\u20133.38), while hemorrhagic stroke risk gradually increased and had an aHR of 4.64 (2.47\u22128.73) after 10 to 15 years of childbirth (both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Among the 4 HDP subtypes, chronic hypertension with superimposed preeclampsia had the highest stroke risk (aHR=3.86, 1.91\u22127.82,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), followed by preeclampsia\u2013eclampsia (aHR=2.00, 1.63\u22122.45,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), and gestational hypertension (aHR=1.68, 1.13\u22122.52,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05); chronic preexisting hypertension had the lowest stroke risk (aHR=1.27, 0.97\u22121.68,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt;0.05). Furthermore, multiple HDP combined with preeclampsia had aHR of 5.48 (1.14\u221226.42,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The effect of HDP on the risk of future stroke persisted for up to 17 years, both for ischemic and hemorrhagic strokes. The presence of multiple HDP and preeclampsia further increase the stroke risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.121.034109","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T05:00:27Z","timestamp":1641358827000},"page":"338-344","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Impact of Hypertensive Disorders of Pregnancy on the Risk of Stroke Stratified by Subtypes and Follow-Up Time"],"prefix":"10.1161","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-528X","authenticated-orcid":true,"given":"Shih-Kai","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan (S.-K.H., M.-S.L., H.-Y.L., L.-C.C., C.-H.C., B.-H.Y., H.-J.Y., F.-C.H., W.-Y.C.)."},{"name":"School of Medicine, Tzu Chi University, Hualien, Taiwan (S.-K.H., M.-S.L., H.-Y.L., C.-J.C., W.-Y.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon-Sing","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan (S.-K.H., M.-S.L., H.-Y.L., L.-C.C., C.-H.C., B.-H.Y., H.-J.Y., F.-C.H., W.-Y.C.)."},{"name":"School of Medicine, Tzu Chi University, Hualien, Taiwan (S.-K.H., M.-S.L., H.-Y.L., C.-J.C., W.-Y.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hon-Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan (S.-K.H., M.-S.L., H.-Y.L., L.-C.C., C.-H.C., B.-H.Y., H.-J.Y., F.-C.H., W.-Y.C.)."},{"name":"School of Medicine, Tzu Chi University, Hualien, Taiwan (S.-K.H., M.-S.L., H.-Y.L., C.-J.C., W.-Y.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan (S.-K.H., M.-S.L., H.-Y.L., L.-C.C., C.-H.C., B.-H.Y., H.-J.Y., F.-C.H., W.-Y.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Jou","family":"Chuang","sequence":"additional","affiliation":[{"name":"School of Medicine, Tzu Chi University, Hualien, Taiwan (S.-K.H., M.-S.L., H.-Y.L., C.-J.C., W.-Y.C.)."},{"name":"Department of Obstetrics and Gynecology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan (C.-J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hui","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan (S.-K.H., M.-S.L., H.-Y.L., L.-C.C., C.-H.C., B.-H.Y., H.-J.Y., F.-C.H., W.-Y.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5122-9655","authenticated-orcid":true,"given":"Ben-Hui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan (S.-K.H., M.-S.L., H.-Y.L., L.-C.C., C.-H.C., B.-H.Y., H.-J.Y., F.-C.H., W.-Y.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7819-0535","authenticated-orcid":true,"given":"Hsuan-Ju","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan (S.-K.H., M.-S.L., H.-Y.L., L.-C.C., C.-H.C., B.-H.Y., H.-J.Y., F.-C.H., 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