{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:31:58Z","timestamp":1790645518831,"version":"4.1.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>\n              Ischemic stroke has been reported in various conditions associated with eosinophilia.\n              <jats:italic>FIP1L1-PDGFRA<\/jats:italic>\n              fusion ([Fip1-like 1-platelet-derived growth factor receptor alpha];\n              <jats:italic>F\/P<\/jats:italic>\n              ) leads to the proliferation of the eosinophilic lineage and thus to a clonal hypereosinophilic syndrome that is highly responsive to imatinib.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              We previously reported on a nationwide retrospective study of 151 patients with\n              <jats:italic>F\/P<\/jats:italic>\n              -associated clonal hypereosinophilic syndrome. Patients from this cohort with a clinical history of ischemic stroke (as well as 2 additional cases) were further analyzed to better define their clinical picture and outcomes.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Sixteen male patients (median age, 51 [43\u201359] years) with low-to-intermediate cardiovascular risk were included. Median National Institutes of Health Stroke Scale was 4 (range, 1\u20136). Most cerebral imaging disclosed multiple bilateral infarctions of watershed distribution (69%). Despite frequent cardiac involvement (50%), cardiac thrombus was evidenced in a single patient and, according to the TOAST classification (Trial of ORG 10172 in Acute Stroke Treatment), 62.5% of strokes were presumably of undetermined etiology. Among the 15 patients treated with imatinib, and after a median follow-up of 4.5 years, stroke recurred in only 3 patients (consisting of either cardio embolic or hemorrhagic events, unrelated to the first episode).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              <jats:italic>F\/P<\/jats:italic>\n              + clonal hypereosinophilic syndrome is a diagnosis to consider in patients with unexplained ischemic stroke and hypereosinophilia (especially in the setting of multiple cortical borderzone distribution) and warrants prompt initiation of imatinib.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.121.034191","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T09:00:33Z","timestamp":1627290033000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["FIP1L1-PDGFRA-Associated Hypereosinophilic Syndrome as a Treatable Cause of Watershed Infarction"],"prefix":"10.1161","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0324-1232","authenticated-orcid":true,"given":"Juliette","family":"Tennenbaum","sequence":"first","affiliation":[{"name":"National Reference Center for Hypereosinophilic syndromes (CEREO), France (J.T., M.G., M. Hamidou, G.L., J.-E.K., J.R.)."},{"name":"Department of Neurology, CHU du Kremlin-Bic\u00eatre, France (J.T., L.V., C.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Groh","sequence":"additional","affiliation":[{"name":"National Reference Center for Hypereosinophilic syndromes (CEREO), France (J.T., M.G., M. Hamidou, G.L., J.-E.K., J.R.)."},{"name":"Department of Internal Medicine, H\u00f4pital Foch, Suresnes, France (M.G., J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2904-9724","authenticated-orcid":true,"given":"Laura","family":"Venditti","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU du Kremlin-Bic\u00eatre, France (J.T., L.V., C.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"France","family":"Campos-Gazeau","sequence":"additional","affiliation":[{"name":"Department of Hematology, H\u00f4pital d\u2019Haguenau, France (F.C.-G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Chalayer","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cell Therapy (E.C.), Saint-Priest-en-Jarez, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"De Broucker","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Delafontaire, Saint Denis, France (T.D.B., A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Hamidou","sequence":"additional","affiliation":[{"name":"National Reference Center for Hypereosinophilic syndromes (CEREO), France (J.T., M.G., M. Hamidou, G.L., J.-E.K., J.R.)."},{"name":"Department of Internal Medicine, CHU de Nantes, France (M. Hamidou)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7777-5216","authenticated-orcid":true,"given":"Mathilde","family":"Hunault","sequence":"additional","affiliation":[{"name":"CRCINA CHU d\u2019Angers, France (M. Hunault)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aicha","family":"Lyoubi","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Delafontaire, Saint Denis, France (T.D.B., A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-425X","authenticated-orcid":true,"given":"Rapha\u00eblle","family":"Meunier","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital de Libourne, France (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Muron","sequence":"additional","affiliation":[{"name":"Department of Oncology (T.M.), Saint-Priest-en-Jarez, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"S\u00e8ne","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, CHU Lariboisi\u00e8re, Paris, France (D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borhane","family":"Slama","sequence":"additional","affiliation":[{"name":"Department of Hematology, H\u00f4pital d\u2019Avignon, France (B.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Guidoux","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU Bichat, Paris, France (C.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Lef\u00e8vre","sequence":"additional","affiliation":[{"name":"National Reference Center for Hypereosinophilic syndromes (CEREO), France (J.T., M.G., M. Hamidou, G.L., J.-E.K., J.R.)."},{"name":"Department of Internal Medicine, CHU Lille, France (G.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Emmanuel","family":"Kahn","sequence":"additional","affiliation":[{"name":"National Reference Center for Hypereosinophilic syndromes (CEREO), France (J.T., M.G., M. Hamidou, G.L., J.-E.K., J.R.)."},{"name":"Department of Internal Medicine, CHU Ambroise Par\u00e9, Boulogne-Billancourt, France (J.-E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2087-5563","authenticated-orcid":true,"given":"Christian","family":"Denier","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU du Kremlin-Bic\u00eatre, France (J.T., L.V., C.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3128-4187","authenticated-orcid":true,"given":"Julien","family":"Rohmer","sequence":"additional","affiliation":[{"name":"National Reference Center for Hypereosinophilic syndromes (CEREO), France (J.T., M.G., M. 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Eur J Radiol Extra. 2007;64:45\u201348.","journal-title":"Eur J Radiol Extra"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000088"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.07.007"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.08.037"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.121.034191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:58:13Z","timestamp":1715612293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.121.034191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1161\/STROKEAHA.121.034191"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.121.034191","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"2021-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}