{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:28:29Z","timestamp":1789468109916,"version":"build-2803163510"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Takayasu arteritis (TA) is a large vessel vasculitis that may complicate with cerebrovascular ischemic events. The objective was to describe clinical and vascular features of TA patients with cerebrovascular ischemic events and to identify risk factors for these events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed the prevalence and type of stroke\/transient ischemic attack (TIA), factors associated with cerebrovascular ischemic events, and stroke-free survival in a large cohort fulfilling the American College of Rheumatology or Ishikawa criteria of TA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 320 patients with TA (median age at diagnosis, 36 [25\u201347] years; 261 [86%] women), 63 (20%) had a stroke (n=41; 65%) or TIA (n=22; 35%). Ischemic event localized in the carotid territory for 55 (87%) patients and the vertebral artery territory in 8 (13%) patients. Multiple stenosis were observed in 33 (52%) patients with a median number of stenosis of 2 (minimum, 0 to maximum, 11), and aneurysms were observed in 10 (16%) patients. A history of stroke or TIA before TA diagnosis (hazard ratio [HR], 4.50 [2.45\u20138.17];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001), smoking (HR, 1.75 [1.01\u20133.02];\n                      <jats:italic>P<\/jats:italic>\n                      =0.05), myocardial infarction history (HR, 0.21 [0.05\u20130.89];\n                      <jats:italic>P<\/jats:italic>\n                      =0.039), thoracic aorta involvement (HR, 2.05 [1.30\u20133.75];\n                      <jats:italic>P<\/jats:italic>\n                      =0.023), time from first symptoms to diagnosis &gt;1 year (HR, 2.22 [1.30\u20133.80];\n                      <jats:italic>P<\/jats:italic>\n                      =0.005), and aspirin treatment (HR, 1.82 [1.04\u20133.19];\n                      <jats:italic>P<\/jats:italic>\n                      =0.035) were associated with cerebrovascular ischemic event. In multivariate analysis, time from first symptoms to TA diagnosis &gt;1 year (HR, 2.16 [1.27\u20133.70];\n                      <jats:italic>P<\/jats:italic>\n                      =0.007) was independently associated with cerebrovascular ischemic events in patients with TA. The HR for cerebrovascular ischemic event in patients who already experienced a stroke\/TIA was 5.11 (2.91\u20138.99;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001), compared with those who had not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Carotid stroke\/TIA is frequent in TA. We identified factors associated with cerebrovascular ischemic events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.121.034445","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T05:01:47Z","timestamp":1648702907000},"page":"1550-1557","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Cerebrovascular Ischemic Events in Patients With Takayasu Arteritis"],"prefix":"10.1161","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5755-8043","authenticated-orcid":true,"given":"Adrien","family":"Mirouse","sequence":"first","affiliation":[{"name":"Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Department of Internal Medicine and Clinical Immunology, Sorbonne Universit\u00e9s (A. Mirouse, C.P., P. Cacoub, D.S.), APHP, Paris, France."},{"name":"Centre National de R\u00e9f\u00e9rences Maladies Autoimmunes et Syst\u00e9miques Rares, Centre National de R\u00e9f\u00e9rences Maladies Autoinflammatoires Rares et Amylose Inflammatoire, INSERM, UMR S 959, Immunology-Immunopathology-Immunotherapy, Paris, France (A. Mirouse, C.P., P. Cacoub, D.S.)."},{"name":"Sorbonne Universit\u00e9, Paris, France (A. Mirouse, A. Mekinian, F.K., P. Cluzel, A.R., P. Cacoub, D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9500-823X","authenticated-orcid":true,"given":"Sandrine","family":"Deltour","sequence":"additional","affiliation":[{"name":"Service de Neurologie, H\u00f4pital Raymond Poincar\u00e9, APHP, Universit\u00e9 Versailles Saint Quentin en Yvelines, Garches, France (S.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1110-3833","authenticated-orcid":true,"given":"Delphine","family":"Leclercq","sequence":"additional","affiliation":[{"name":"Service de Neuro-Radiologie, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re (D.L.), APHP, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5998-8285","authenticated-orcid":true,"given":"Pierre-Alexandre","family":"Squara","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pital Saint Louis, Service de Biostatistique et Information M\u00e9dicale (DMU PRISME), INSERM U1153 Team ECSTRRA, Universit\u00e9 de Paris, France (P.-A.S., L.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Pouchelon","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Department of Internal Medicine and Clinical Immunology, Sorbonne Universit\u00e9s (A. Mirouse, C.P., P. Cacoub, D.S.), APHP, Paris, France."},{"name":"Centre National de R\u00e9f\u00e9rences Maladies Autoimmunes et Syst\u00e9miques Rares, Centre National de R\u00e9f\u00e9rences Maladies Autoinflammatoires Rares et Amylose Inflammatoire, INSERM, UMR S 959, Immunology-Immunopathology-Immunotherapy, Paris, France (A. Mirouse, C.P., P. Cacoub, D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clo\u00e9","family":"Comarmond","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, H\u00f4pital Lariboisi\u00e8re (C.C.), APHP, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Emmanuel","family":"Kahn","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital Ambroise Par\u00e9, APHP, Boulogne, France (J.-E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ygal","family":"Benhamou","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, Vasculaire et Thrombose, CHU de Rouen, France (Y.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-1093","authenticated-orcid":true,"given":"Tristan","family":"Mirault","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital Europ\u00e9en Georges Pompidou (T.M.), APHP, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ars\u00e8ne","family":"Mekinian","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital Saint-Antoine (A. 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Cacoub, D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Cluzel","sequence":"additional","affiliation":[{"name":"Service de Radiologie Interventionnelle, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re (P. Cluzel), APHP, Paris, France."},{"name":"Sorbonne Universit\u00e9, Paris, France (A. Mirouse, A. Mekinian, F.K., P. Cluzel, A.R., P. Cacoub, D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Redheuil","sequence":"additional","affiliation":[{"name":"Service de Radiologie et Imagerie Cardio-Vasculaire, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re (A.R.), APHP, Paris, France."},{"name":"Sorbonne Universit\u00e9, Paris, France (A. Mirouse, A. Mekinian, F.K., P. Cluzel, A.R., P. Cacoub, D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-4992","authenticated-orcid":true,"given":"Patrice","family":"Cacoub","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Department of Internal Medicine and Clinical Immunology, Sorbonne Universit\u00e9s (A. Mirouse, C.P., P. Cacoub, D.S.), APHP, Paris, France."},{"name":"Centre National de R\u00e9f\u00e9rences Maladies Autoimmunes et Syst\u00e9miques Rares, Centre National de R\u00e9f\u00e9rences Maladies Autoinflammatoires Rares et Amylose Inflammatoire, INSERM, UMR S 959, Immunology-Immunopathology-Immunotherapy, Paris, France (A. Mirouse, C.P., P. Cacoub, D.S.)."},{"name":"Sorbonne Universit\u00e9, Paris, France (A. Mirouse, A. Mekinian, F.K., P. Cluzel, A.R., P. 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