{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:44:55Z","timestamp":1771328695875,"version":"3.50.1"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>Patients with prestroke mobility impairment (PSMI) were excluded from endovascular clinical trials. There are limited data regarding safety and outcomes of endovascular thrombectomy in this population. We used a large, national data set (Get With The Guidelines\u2013Stroke) to evaluate the safety and outcomes of endovascular thrombectomy in patients with PSMI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We included patients who underwent endovascular thrombectomy in the Get With The Guidelines\u2013Stroke registry between 2015 and 2019. PSMI was defined as the inability to ambulate independently. Generalized estimating equations for logistic regression models were used to evaluate the association between PSMI and outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Of 56 762 patients treated with endovascular thrombectomy, 2919 (5.14%) had PSMI. PSMI was not associated with symptomatic intracranial hemorrhage (6.0% versus 5.4%;\n              <jats:italic>P<\/jats:italic>\n              =0.979). In-hospital death or discharge to hospice occurred in 32.3% of patients with PSMI versus 17.5% without PSMI (adjusted odds ratio, 1.45 [1.32\u20131.58]).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>While procedural adverse outcomes were no higher in patients with PSMI, further study is necessary to determine clinical benefit in this population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.121.034464","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T09:00:27Z","timestamp":1631610027000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes of Endovascular Therapy in Patients With Prestroke Mobility Impairment"],"prefix":"10.1161","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7870-6762","authenticated-orcid":true,"given":"Rachel","family":"Beekman","sequence":"first","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT (R.B., K.N.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie-Lena","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (J.-L.S., B.A., Y.X., S.S., B.L.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke","family":"Alhanti","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (J.-L.S., B.A., Y.X., S.S., B.L.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0592-9145","authenticated-orcid":true,"given":"Lee H.","family":"Schwamm","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston (L.H.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3956-1668","authenticated-orcid":true,"given":"Eric E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Alberta, Canada (E.E.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-6245","authenticated-orcid":true,"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Brigham and Women\u2019s Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA (D.L.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1237-1162","authenticated-orcid":true,"given":"Ying","family":"Xian","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (J.-L.S., B.A., Y.X., S.S., B.L.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8441-6326","authenticated-orcid":true,"given":"Shreyansh","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (J.-L.S., B.A., Y.X., S.S., B.L.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara L.","family":"Lytle","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (J.-L.S., B.A., Y.X., S.S., B.L.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3192-8093","authenticated-orcid":true,"given":"Gregg C.","family":"Fonarow","sequence":"additional","affiliation":[{"name":"Division of Cardiology\/Department of Medicine, Ronald-Regan UCLA Medical Center, Los Angeles, CA (G.C.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-5473","authenticated-orcid":true,"given":"Kevin N.","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT (R.B., K.N.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00651"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.561787"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414792"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414905"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503780"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415061"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00275"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3429"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009898"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.101"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.783688"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-88-3-424"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09882-5"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.08.007"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.028246"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5920"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.12.012"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.121.034464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:53:02Z","timestamp":1715611982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.121.034464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1161\/STROKEAHA.121.034464"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.121.034464","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"2020-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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