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Prior research and consensus recommendations have focused on modernizing 2 aspects of the mRS: operationalized assignment of scale scores and statistical analysis of scale distributions. Another important characteristic of the mRS still requiring elaboration and specification to contemporary clinimetric standards is the Naming of scale outcomes. Recent clinical trials have used a bewildering variety, often mutually contradictory, of rubrics to describe scale states. Understanding of the meaning of mRS outcomes by clinicians, patients, and other clinical trial stakeholders would be greatly enhanced by use of a harmonized, uniform set of labels for the distinctive mRS outcomes that would be used consistently across trials. This statement advances such recommended rubrics, developed by the Stroke Therapy Academic Industry Roundtable collaboration using an iterative, mixed-methods process. Specific guidance is provided for health state terms (eg, Symptomatic but Nondisabled for mRS score 1; requires constant care for mRS score 5) and valence terms (eg, excellent for mRS score 1; very poor for mRS score 5) to employ for 23 distinct numeric mRS outcomes, including: all individual 7 mRS levels; all 12 positive and negative dichotomized mRS ranges, positive and negative sliding dichotomies; and utility-weighted analysis of the mRS.<\/jats:p>","DOI":"10.1161\/strokeaha.121.034480","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T05:00:14Z","timestamp":1627534814000},"page":"3054-3062","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":326,"title":["Standardized Nomenclature for Modified Rankin Scale Global Disability Outcomes: Consensus Recommendations From Stroke Therapy Academic Industry Roundtable XI"],"prefix":"10.1161","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-2251","authenticated-orcid":true,"given":"Jeffrey L.","family":"Saver","sequence":"first","affiliation":[{"name":"Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine at UCLA, Los Angeles, CA (J.L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-2119","authenticated-orcid":true,"given":"Napasri","family":"Chaisinanunkul","sequence":"additional","affiliation":[{"name":"Phyathai Comprehensive Stroke Center, Phyathai 1 Hospital, Bangkok, Thailand (N.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce C.V.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Melbourne Brain Centre, Royal Melbourne Hospital, Australia (B.C.V.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Grotta","sequence":"additional","affiliation":[{"name":"Memorial Hermann Hospital-Texas Medical Center, Houston (J.C.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary and Foothills Medical Centre, AB, Canada (M.D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Khatri","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation Sciences, University of Cincinnati, OH (P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaren","family":"Landen","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA (J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten G.","family":"Lansberg","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences and the Stanford Stroke Center, Stanford University (M.G.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Venkatasubramanian","sequence":"additional","affiliation":[{"name":"Division of Stroke and Neurocritical Care, Department of Neurology and Neurological Sciences and the Stanford Stroke Center, Stanford University (C.V., G.W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Albers","sequence":"additional","affiliation":[{"name":"Division of Stroke and Neurocritical Care, Department of Neurology and Neurological Sciences and the Stanford Stroke Center, Stanford University (C.V., G.W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the XIth Stroke Treatment Academic Industry Roundtable","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.31.6.1429"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000258355.23810.c6"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.8286"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027071"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.033502"},{"key":"e_1_3_6_7_2","unstructured":"European Medicines Agency. 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