{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:02:57Z","timestamp":1791820977691,"version":"4.3.4"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose:<\/jats:title>\n                    <jats:p>Optimizing speech and language therapy (SLT) regimens for maximal aphasia recovery is a clinical research priority. We examined associations between SLT intensity (hours\/week), dosage (total hours), frequency (days\/week), duration (weeks), delivery (face to face, computer supported, individual tailoring, and home practice), content, and language outcomes for people with aphasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Databases including MEDLINE and Embase were searched (inception to September 2015). Published, unpublished, and emerging trials including SLT and \u226510 individual participant data on aphasia, language outcomes, and time post-onset were selected. Patient-level data on stroke, language, SLT, and trial risk of bias were independently extracted. Outcome measurement scores were standardized. A statistical inferencing, one-stage, random effects, network meta-analysis approach filtered individual participant data into an optimal model examining SLT regimen for overall language, auditory comprehension, naming, and functional communication pre-post intervention gains, adjusting for a priori\u2013defined covariates (age, sex, time poststroke, and baseline aphasia severity), reporting estimates of mean change scores (95% CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Data from 959 individual participant data (25 trials) were included. Greatest gains in overall language and comprehension were associated with &gt;20 to 50 hours SLT dosage (18.37 [10.58\u201326.16] Western Aphasia Battery\u2013Aphasia Quotient; 5.23 [1.51\u20138.95] Aachen Aphasia Test\u2013Token Test). Greatest clinical overall language, functional communication, and comprehension gains were associated with 2 to 4 and 9+ SLT hours\/week. Greatest clinical gains were associated with frequent SLT for overall language, functional communication (3\u20135+ days\/week), and comprehension (4\u20135 days\/week). Evidence of comprehension gains was absent for SLT \u226420 hours, &lt;3 hours\/week, and \u22643 days\/week. Mixed receptive-expressive therapy, functionally tailored, with prescribed home practice was associated with the greatest overall gains. Relative variance was &lt;30%. Risk of trial bias was low to moderate; low for meta-biases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Greatest language recovery was associated with frequent, functionally tailored, receptive-expressive SLT, with prescribed home practice at a greater intensity and duration than reports of usual clinical services internationally. These exploratory findings suggest critical therapeutic ranges, informing hypothesis-testing trials and tailoring of clinical services.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/PROSPERO\/\">https:\/\/www.crd.york.ac.uk\/PROSPERO\/<\/jats:ext-link>\n                      ; Unique identifier: CRD42018110947.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.121.035216","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T05:00:54Z","timestamp":1638334854000},"page":"956-967","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":127,"title":["Dosage, Intensity, and Frequency of Language Therapy for Aphasia: A Systematic Review\u2013Based, Individual Participant Data Network Meta-Analysis"],"prefix":"10.1161","volume":"53","author":[{"name":"The REhabilitation and recovery of peopLE with Aphasia after StrokE (RELEASE) Collaborators","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4589-7021","authenticated-orcid":true,"given":"Marian 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