{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:04:13Z","timestamp":1792641853074,"version":"4.5.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2022,2]]},"abstract":"\n Background and Purpose:<\/jats:title>\n Achieving complete revascularization after a single pass of a mechanical thrombectomy device (first pass effect [FPE]) is associated with good clinical outcomes in patients with acute ischemic stroke due to large vessel occlusion. We assessed patient characteristics, outcomes, and predictors of FPE among a large real-world cohort of patients (Systematic Evaluation of Patients Treated with Stroke Devices for Acute Ischemic Stroke registry).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Demographics, clinical outcomes, and procedural characteristics were analyzed among patients in whom FPE (modified Thrombolysis in Cerebral Infarction 2c\/3 after first pass) was achieved versus those requiring multiple passes (MP). Modified FPE and modified MP included patients achieving modified Thrombolysis in Cerebral Infarction 2B-3. Primary outcomes included 90-day modified Rankin Scale (mRS) score and mortality.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Among 984 Systematic Evaluation of Patients Treated with Stroke Devices for Acute Ischemic Stroke patients, 930 had complete 90-day follow-up. FPE was achieved in 40.5% (377\/930) of patients and MP in 20.0% (186\/930). Baseline characteristics were similar across all groups. The FPE group had fewer internal carotid artery occlusions compared with MP (\n P<\/jats:italic>\n =0.029). The FPE group had faster puncture to recanalization time (\n P<\/jats:italic>\n \u22640.001), higher rates of 90-day mRS score of 0 to 1 (52.6% versus 38.6%,\n P<\/jats:italic>\n =0.003), mRS score of 0 to 2 (65.4% versus 52.0%,\n P<\/jats:italic>\n =0.003), and lower 90-day mortality compared with the MP group (12.0% versus 18.7%,\n P<\/jats:italic>\n =0.038). Similarly, compared with modified MP patients, the modified FPE group had fewer internal carotid artery occlusions (\n P<\/jats:italic>\n =0.004), faster puncture to recanalization time (\n P<\/jats:italic>\n \u22640.001), and higher rates of 90-day mRS score of 0 to 1 (\n P<\/jats:italic>\n =0.002) and mRS score of 0 to 2 (\n P<\/jats:italic>\n =0.003).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Our findings demonstrate that FPE and modified FPE are associated with superior clinical outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/strokeaha.121.035457","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T05:01:52Z","timestamp":1637125312000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":51,"title":["First Pass Effect With Neurothrombectomy for Acute Ischemic Stroke: Analysis of the Systematic Evaluation of Patients Treated With Stroke Devices for Acute Ischemic Stroke Registry"],"prefix":"10.1161","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9454-0678","authenticated-orcid":true,"given":"Ashutosh P.","family":"Jadhav","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, Barrow Neurological Institute, Phoenix, AZ (A.P.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashvat M.","family":"Desai","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute, Scottsdale, AZ (S.M.D)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama O.","family":"Zaidat","sequence":"additional","affiliation":[{"name":"Mercy Health-St. Vincent Mercy Medical Center, Toledo, OH (O.O.Z)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul G.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University Grady Memorial Hospital, Atlanta, GA (R.G.N., D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudor G.","family":"Jovin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cooper University, Camden, NJ (T.G.J)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo C.","family":"Haussen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University Grady Memorial Hospital, Atlanta, GA (R.G.N., D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Mueller-Kronast","sequence":"additional","affiliation":[{"name":"Advanced Neuroscience Network\/Tenet South Florida, Boynton Beach, FL (N.H.M.-K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Liebeskind","sequence":"additional","affiliation":[{"name":"Neurovascular Imaging Research Core and Stroke Center, Department of Neurology, UCLA, Los Angeles, CA (D.S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2020-016952"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.020315"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016456"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015321"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013179"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022987"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.10.155"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6074"},{"key":"e_1_3_2_10_2","unstructured":"Abstract WP18: the impact of fast versus slow infarct growth on recanalization in patients presenting with acute ischemic stroke. Stroke [Internet]. https:\/\/www.ahajournals.org\/doi\/10.1161\/str.50.suppl_1.WP18."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015330"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.121.035457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:27:04Z","timestamp":1770384424000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.121.035457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1161\/STROKEAHA.121.035457"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.121.035457","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"2021-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}