{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:00:43Z","timestamp":1789880443049,"version":"4.0.1"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>Basilar artery occlusion stroke is known to have poor outcome with a high rate of morbidity and mortality despite best medical therapy. Since the original report of intra-arterial therapy for basilar artery occlusion in 1983, two recent randomized trials comparing endovascular therapy versus best medical management were completed on a large scale, BASICS (Basilar Artery International Cooperation Study) and the BEST trial (Basilar Artery Occlusion Endovascular Intervention Versus Standard Medical Treatment), both of which demonstrated equivocal benefit of the two modalities. In this commentary, we comment and highlight important lessons related to basilar occlusion stroke as learned from the BASICS and BEST randomized trials.<\/jats:p>","DOI":"10.1161\/strokeaha.121.035948","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T09:00:27Z","timestamp":1631610027000},"page":"3410-3413","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Endovascular Therapy for Stroke due to Basilar Artery Occlusion"],"prefix":"10.1161","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-1685","authenticated-orcid":true,"given":"Thanh N.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Neurology, Radiology, Boston Medical Center, Boston University School of Medicine, MA (T.N.N.)."},{"name":"Department of Neurology, Helsinki University Central Hospital, Finland (D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9095-2344","authenticated-orcid":true,"given":"Daniel","family":"Strbian","sequence":"additional","affiliation":[{"name":"Department of Neurology, Radiology, Boston Medical Center, Boston University School of Medicine, MA (T.N.N.)."},{"name":"Department of Neurology, Helsinki University Central Hospital, Finland (D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70173-5"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/2396987316629889"},{"key":"e_1_3_4_4_2","first-page":"401","article-title":"Local intraarterial thrombolysis in vertebrobasilar thromboembolic disease.","volume":"4","author":"Zeumer H","year":"1983","unstructured":"Zeumer, H, Hacke, W, Ringelstein, EB. Local intraarterial thrombolysis in vertebrobasilar thromboembolic disease. AJNR Am J Neuroradiol. 1983;4:401\u2013404.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2030297"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30395-3"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000202582.29510.6b"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000567"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2000120"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-14-200"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.004884"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.609693"},{"key":"e_1_3_4_16_2","volume-title":"In: Vertebrobasilar occlusion randomization to endovascular reperfusion versus intravenous thrombolysis or medical treatment alone. Systematic evaluation (VERITAS) Collaboration","author":"Nogueira RG","unstructured":"Nogueira, RG, Liu, X, Vos, JA, Dai, Q, Ye, R, Zi, W, Xu, G, Ye, R, Langezaal, LCM, Algra, A, et al. Vertebrobasilar occlusion randomization to endovascular reperfusion versus intravenous thrombolysis or medical treatment alone. Systematic evaluation (VERITAS) Collaboration. In: Vertebrobasilar occlusion randomization to endovascular reperfusion versus intravenous thrombolysis or medical treatment alone. Systematic evaluation (VERITAS) Collaboration. International Stroke Conference March 19, 2021."},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214300"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1212793"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.121.035948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:55:24Z","timestamp":1715612124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.121.035948"}},"subtitle":["A BASIC Challenge at BEST"],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1161\/STROKEAHA.121.035948"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.121.035948","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"2021-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}