{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T03:15:45Z","timestamp":1794366945955,"version":"4.9.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose:<\/jats:title>\n                    <jats:p>To assess the association between systolic blood pressure change (\u0394SBP) at different time intervals after successful reperfusion with radiographic and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a post hoc analysis of the BP-TARGET multicenter trial (Blood Pressure Target in Acute Stroke to Reduce Hemorrhage After Endovascular Therapy). \u0394SBP was defined as end of procedure SBP minus mean SBP at different time intervals (15\u201360 minutes, 1\u20136 hours, and 6\u201324 hours postprocedure). The primary outcome was the poor functional outcome (90-day modified Rankin Scale score 3\u20136).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We included a total of 267 patients (130 in the intensive treatment group). Compared with patients with favorable outcome, patients with poor outcome had lower \u0394SBP (less SBP reduction) at all times intervals. After adjusting for potential confounders including baseline SBP, both \u0394SBP\n                      <jats:sub>15<\/jats:sub>\n                      <jats:sub>\u201360M<\/jats:sub>\n                      and \u0394SBP\n                      <jats:sub>6<\/jats:sub>\n                      <jats:sub>\u201324H<\/jats:sub>\n                      were associated with lower odds of poor outcome (adjusted odds ratio per 5 mm\u2009Hg SBP reduction, 0.89 [95% CI, 0.81\u20130.99], and adjusted odds ratio 0.82 [95% CI, 0.73\u20130.92], respectively). Concerning safety outcomes, patients with intraparenchymal hemorrhage had lower \u0394SBP at all time intervals. \u0394SBP\n                      <jats:sub>15<\/jats:sub>\n                      <jats:sub>\u201360M<\/jats:sub>\n                      was associated with lower odds of any intraparenchymal hemorrhage (adjusted odds ratio per 5 mm\u2009Hg SBP reduction 0.91 [95% CI, 0.83\u20130.99]). Conversely, \u0394SBP was not associated with mortality or neurological deterioration at any time interval.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>After successful reperfusion, \u0394SBP had a linear relationship with poor outcome and the risk of poor outcome was higher with less reduction from the baseline SBP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03160677.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.121.036701","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T05:00:21Z","timestamp":1643864421000},"page":"719-727","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Magnitude of Blood Pressure Change After Endovascular Therapy and Outcomes: Insight From the BP-TARGET Trial"],"prefix":"10.1161","volume":"53","clinical-trial-number":[{"clinical-trial-number":"nct03160677","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-2949","authenticated-orcid":true,"given":"Mohammad","family":"Anadani","sequence":"first","affiliation":[{"name":"Department of Neurology, Washington University, St Louis, MO (M.A.)."},{"name":"Department of Neurosurgery, Medical University of South Carolina, Charleston (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3993-1024","authenticated-orcid":true,"given":"Benjamin","family":"Ma\u00efer","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, H\u00f4pital Fondation Ophtalmologique Adolphe de Rothschild, Paris, France (B.M., S.E., J.-P.D., R.B., M.P., M.M.)."},{"name":"University of Paris, France (B.M., J.-P.D., M.M.)."},{"name":"FHU Neurovasc, Paris, France (B.M., J.-P.D., R.B., M.P., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1306-1008","authenticated-orcid":true,"given":"Simon","family":"Escalard","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, H\u00f4pital Fondation Ophtalmologique Adolphe de Rothschild, Paris, France (B.M., S.E., J.-P.D., R.B., M.P., 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