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The field of epitranscriptomics is blossoming and quickly advancing in fields like cancer research, nevertheless, poorly understood in the context of cardiovascular disease. Epitranscriptomic modifications are shown to regulate the metabolism and function of RNA molecules, which are important for cell functions such as cell proliferation, a key aspect in atherogenesis. As such, epitranscriptomic regulatory mechanisms can serve as novel checkpoints in gene expression during disease development. In this review, we describe examples of the latest research investigating epitranscriptomic modifications, in particular A-to-I editing and the covalent modification\n            <jats:italic>N<\/jats:italic>\n            <jats:sup>6<\/jats:sup>\n            -methyladenosine and their regulatory proteins, in the context of cardiovascular disease. We additionally discuss the potential of these mechanisms as therapeutic targets and novel treatment options.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.121.037581","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T10:00:25Z","timestamp":1646388025000},"page":"2114-2122","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Epitranscriptome in Ischemic Cardiovascular Disease: Potential Target for Therapies"],"prefix":"10.1161","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0090-589X","authenticated-orcid":true,"given":"Ana","family":"Quiles-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Research Institute for Internal Medicine (A.Q.-J., T.B.D., B.H., I.G.), Oslo University Hospital, Rikshospitalet, Norway."},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway (A.Q.-J., B.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7818-9411","authenticated-orcid":true,"given":"Tuva B.","family":"Dahl","sequence":"additional","affiliation":[{"name":"Research Institute for Internal Medicine (A.Q.-J., T.B.D., B.H., I.G.), Oslo University Hospital, Rikshospitalet, Norway."},{"name":"Division of Critical Care and Emergencies (T.B.D.), Oslo University Hospital, Rikshospitalet, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnar","family":"Bj\u00f8r\u00e5s","sequence":"additional","affiliation":[{"name":"Department of Microbiology (M.B., I.A.), Oslo University Hospital, Rikshospitalet, Norway."},{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway (M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-2652","authenticated-orcid":true,"given":"Ingrun","family":"Alseth","sequence":"additional","affiliation":[{"name":"Department of Microbiology (M.B., I.A.), Oslo University Hospital, Rikshospitalet, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente","family":"Halvorsen","sequence":"additional","affiliation":[{"name":"Research Institute for Internal Medicine (A.Q.-J., T.B.D., B.H., I.G.), Oslo University Hospital, Rikshospitalet, Norway."},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway (A.Q.-J., B.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9500-0518","authenticated-orcid":true,"given":"Ida","family":"Gregersen","sequence":"additional","affiliation":[{"name":"Research Institute for Internal Medicine (A.Q.-J., T.B.D., B.H., I.G.), Oslo University Hospital, Rikshospitalet, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.042"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.01270"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107514"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.118.001927"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.063503.117"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201511041"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170077"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1030"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201201193"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.31"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/b95147","volume-title":"In: Fine-tuning of rna functions by modification and editing","author":"Grosjean H","year":"2005","unstructured":"Grosjean, H. 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