{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:39:55Z","timestamp":1790372395878,"version":"4.1.0"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Accurate estimates of risks of poststroke outcomes from large population\u2013based studies can provide a basis for public health policy decisions. We examined the absolute and relative risks of a spectrum of incident mental disorders following ischemic stroke and intracerebral hemorrhage.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>During 2004 to 2018, we used Danish registries to identify patients (\u226518 years and with no hospital history of mental disorders), with a first-time ischemic stroke (n=76\u2009767) or intracerebral hemorrhage (n=9344), as well as age-,sex-, and calendar year\u2013matched general population (n=464\u2009840) and myocardial infarction (n=92\u2009968) comparators. We computed risk differences, considering death a competing event, and hazard ratios adjusted for income, occupation, education, and history of cardiovascular and noncardiovascular comorbidity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Compared with the general population, following ischemic stroke, the 1-year risk difference was 7.3% (95% CI, 7.0\u20137.5) for mood disorders (driven by depression), 1.4% (95% CI, 1.3\u20131.5) for organic brain disorders (driven by dementia and delirium), 0.8% (95% CI, 0.7\u20130.8) for substance abuse disorders (driven by alcohol and tobacco abuse), and 0.5% (95% CI, 0.4\u20130.5) for neurotic disorders (driven by anxiety and stress disorders). For suicide, risk differences were near null. Hazard ratios were particularly elevated in the first year of follow-up, ranging from a 2- to a 4-fold increased hazard, decreasing thereafter. Compared with myocardial infarction patients, the 1-year risk difference was 4.9% (95% CI, 4.6 to 5.3) for mood disorders, 1.0% (95% CI, 0.8 to 1.1) for organic brain disorders, 0.1% (95% CI, 0.0 to 0.2) for substance abuse disorders, but \u22120.2% (95% CI, \u22120.2 to \u22120.1) for neurotic disorders. Hazard ratios during the first year of follow-up were elevated 1.1- to 1.8-fold for mood, organic brain, and neurotic disorders, while decreased 0.8-fold for neurotic disorders.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The considerably greater risks of mental disorders following a stroke, particularly mood disorders, underline the importance of mental health evaluation after stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.121.037740","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T09:00:33Z","timestamp":1648026033000},"page":"2287-2298","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Stroke and Risk of Mental Disorders Compared With Matched General Population and Myocardial Infarction Comparators"],"prefix":"10.1161","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8351-7133","authenticated-orcid":true,"given":"Nils","family":"Skajaa","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University, Aarhus University Hospital, Denmark (N.S., K.A., E.H.-P., K.J.R., V.W.H., H.T.S.)."},{"name":"National Institute of Public Health, University of Southern Denmark, Copenhagen (N.S., L.C.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5639-7252","authenticated-orcid":true,"given":"Kasper","family":"Adelborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University, Aarhus University Hospital, Denmark (N.S., K.A., E.H.-P., K.J.R., V.W.H., H.T.S.)."},{"name":"Department of Clinical Biochemistry, Thrombosis and Haemostasis Research Unit, Aarhus University Hospital, Denmark (K.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-2212","authenticated-orcid":true,"given":"Erzs\u00e9bet","family":"Horv\u00e1th-Puh\u00f3","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University, Aarhus University Hospital, Denmark (N.S., K.A., E.H.-P., K.J.R., V.W.H., H.T.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2398-1705","authenticated-orcid":true,"given":"Kenneth J.","family":"Rothman","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University, Aarhus University Hospital, Denmark (N.S., K.A., E.H.-P., K.J.R., V.W.H., H.T.S.)."},{"name":"Department of Epidemiology, Boston University School of Public Health, MA (K.J.R., H.T.S.)."},{"name":"RTI Health Solutions, Research Triangle Institute, Research 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