{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:30:36Z","timestamp":1762432236876,"version":"build-2065373602"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Young patients with aneurysmal subarachnoid hemorrhage (aSAH) and a history of migraine may have an increased risk of delayed cerebral ischemia. We investigated this potential association in a prospective cohort of aSAH patients under 50 years of age.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>In our prospective cohort study, we included patients with aSAH under 50 years of age from 3 hospitals in the Netherlands. We assessed lifetime migraine history with a short screener. Delayed cerebral ischemia was defined as neurological deterioration lasting &gt;1 hour not attributable to other causes by diagnostic workup. Adjustments were made for possible confounders in multivariable Cox regression analyses, and adjusted hazard ratios were calculated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>We included 236 young aSAH patients (mean age, 41 years; 64% women) of whom 44 (19%) had a history of migraine (16 with aura). Patients with aSAH and a history of migraine were not at increased risk of developing delayed cerebral ischemia compared with patients without migraine (25% versus 20%; adjusted hazard ratio, 1.16 [95% CI, 0.57\u20132.35]). Additionally, no increased risk was found in migraine patients with aura (adjusted hazard ratio, 0.85 [95% CI, 0.30\u20132.44]) or in women (adjusted hazard ratio, 1.24 [95% CI, 0.58\u20132.68]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Patients with aSAH under the age of 50 years with a history of migraine are not at increased risk of delayed cerebral ischemia.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.121.038350","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T09:00:25Z","timestamp":1651827625000},"page":"2075-2077","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage in Young Patients With a History of Migraine"],"prefix":"10.1161","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8911-8608","authenticated-orcid":true,"given":"Hendrikus J.A.","family":"van Os","sequence":"first","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, the Netherlands (H.J.A.v.O., M.J.H.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9212-5470","authenticated-orcid":true,"given":"Dagmar","family":"Verbaan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Amsterdam Neuroscience, Amsterdam UMC (D.V., B.A.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5396-2989","authenticated-orcid":true,"given":"Ynte M.","family":"Ruigrok","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, the Netherlands (Y.M.R., M.D.I.V.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4560-4775","authenticated-orcid":true,"given":"Paul","family":"Dennesen","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Haaglanden Medical Center, The Hague, the Netherlands (P.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5309-179X","authenticated-orcid":true,"given":"Marcella C.A.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam UMC, University of Amsterdam, the Netherlands (M.C.A.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert A.","family":"Coert","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Amsterdam Neuroscience, Amsterdam UMC (D.V., B.A.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6823-1628","authenticated-orcid":true,"given":"Mervyn D.I.","family":"Vergouwen","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, the Netherlands (Y.M.R., M.D.I.V.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-9521","authenticated-orcid":true,"given":"Marieke J.H.","family":"Wermer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, the Netherlands (H.J.A.v.O., M.J.H.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.3.337"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.4.0658"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a636"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01980.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030118"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000449425"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.191"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000273"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2307\/2531395","article-title":"Small-sample bias of point estimators of the odds ratio from matched sets.","volume":"40","author":"Jewell NP","year":"1984","unstructured":"Jewell, NP. Small-sample bias of point estimators of the odds ratio from matched sets. Biometrics. 1984;40:421\u2013435.","journal-title":"Biometrics"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.121.038350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T13:10:12Z","timestamp":1751980212000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.121.038350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1161\/STROKEAHA.121.038350"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.121.038350","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"type":"print","value":"0039-2499"},{"type":"electronic","value":"1524-4628"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2021-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-22","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}