{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:17:03Z","timestamp":1791951423233,"version":"4.3.4"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Recent reports raise the possibility of cerebral amyloid angiopathy (CAA) leading to intracerebral hemorrhage in young adults following childhood neurosurgery, suggesting transmission of amyloid-\u03b2 (A\u03b2) through neurosurgical procedures including dura mater grafting. Parenchymal A\u03b2 deposition, and to a lesser extent tau aggregation, similar to that seen in Alzheimer disease, have also been described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a database review of 634 consecutive intracerebral hemorrhage patients aged &lt;65 years at a tertiary stroke center over 20 years to identify such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We identified 3 patients aged in their thirties who presented with spontaneous lobar intracerebral hemorrhage, with imaging or neuropathology consistent with CAA, and a history of childhood neurosurgery. Two of these patients had undergone a dural repair using cadaveric dura mater (Lyodura). In addition to CAA, both patients had neuropathologically confirmed parenchymal A\u03b2 and tau deposits, characteristic of Alzheimer disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings support the concept of neurosurgical A\u03b2 transmission but suggest that such cases are rare in standard clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.121.038364","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T05:00:21Z","timestamp":1656565221000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Amyloid-\u03b2 (A\u03b2)-Related Cerebral Amyloid Angiopathy Causing Lobar Hemorrhage Decades After Childhood Neurosurgery"],"prefix":"10.1161","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9786-3096","authenticated-orcid":true,"given":"Jeremy F.","family":"Kellie","sequence":"first","affiliation":[{"name":"Departments of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, University of Melbourne, Australia (J.F.K., B.C.V.C., N.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3632-9433","authenticated-orcid":true,"given":"Bruce C.V.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, University of Melbourne, Australia (J.F.K., B.C.V.C., N.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Australia (R.W., S.C.)."},{"name":"Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Australia (R.W., N.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-6238","authenticated-orcid":true,"given":"Adrian J.","family":"Praeger","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (A.J.P., G.N.), The Royal Melbourne Hospital, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (A.J.P., G.N.), The Royal Melbourne Hospital, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Murugasu","sequence":"additional","affiliation":[{"name":"Department of Pathology (A.M.), The Royal Melbourne Hospital, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging and Therapy, Austin Health, Australia (C.C.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-7940","authenticated-orcid":true,"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, Australia (C.L.M., S.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-6611","authenticated-orcid":true,"given":"Steven","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Australia (R.W., S.C.)."},{"name":"The Florey Institute of Neuroscience and Mental Health, Australia (C.L.M., S.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0302-5727","authenticated-orcid":true,"given":"Catriona","family":"McLean","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, The Alfred Hospital, Australia (C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0685-0060","authenticated-orcid":true,"given":"Nawaf","family":"Yassi","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, University of Melbourne, Australia (J.F.K., B.C.V.C., N.Y.)."},{"name":"Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Australia (R.W., N.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25407"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1822-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.01.051"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02326-y"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016990"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301308"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0967-5868(96)90003-x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-321927"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1828-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12197"},{"key":"e_1_3_3_12_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00401-017-1791-x","article-title":"Neuropathology of iatrogenic Creutzfeldt-Jakob disease and immunoassay of French cadaver-sourced growth hormone batches suggest possible transmission of tauopathy and long incubation periods for the transmission of Abeta pathology.","volume":"135","author":"Duyckaerts C","year":"2018","unstructured":"Duyckaerts, C, Sazdovitch, V, Ando, K, Seilhean, D, Privat, N, Yilmaz, Z, Peckeu, L, Amar, E, Comoy, E, Maceski, A, et al. Neuropathology of iatrogenic Creutzfeldt-Jakob disease and immunoassay of French cadaver-sourced growth hormone batches suggest possible transmission of tauopathy and long incubation periods for the transmission of Abeta pathology. Acta Neuropathol. 2018;135:201\u2013212. doSSi: 10.1007\/s00401-017-1791-x","journal-title":"Acta Neuropathol"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.121.038364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:44:51Z","timestamp":1762865091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.121.038364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1161\/STROKEAHA.121.038364"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.121.038364","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"2021-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}