{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:09:42Z","timestamp":1791486582090,"version":"4.3.4"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Limiting the ability to engage in social interaction, aphasia increases the risk of poststroke depression and may prevent classical forms of psychotherapy. Our parallel-group, blinded-assessment, quasi-randomized controlled trial explores the feasibility and potential efficacy of intensive social interaction as a means to alleviate poststroke depression in subacute aphasia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We adopted a linguistically validated treatment program based on massed practice and conversational turn-taking (Intensive Language-Action Therapy). In a routine outpatient setting, 60 individuals with poststroke depression and subacute aphasia (0.5\u20136 months following left-hemispheric ischemia or hemorrhage) were assigned to Intensive Language-Action Therapy combined with standard care (Group I) or standard care alone (Group II). End points included feasibility (primary outcome) alongside change on self-report and clinician-rated measures of depression severity (co-primary outcomes: Beck\u2019s Depression Inventory; Hamilton Rating Scale for Depression) after a 1-month treatment period (5 weekly 1-hour sessions), controlled for progress in language performance (secondary outcome: Aachen Aphasia Test, AAT).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              100% treatment participation demonstrated feasibility of Intensive Language-Action Therapy in poststroke depression. Analyses (\n              <jats:italic>n<\/jats:italic>\n              =60) revealed significant between-group differences on the Beck\u2019s Depression Inventory (change in Group I [95% CI]: \u221212.6 [\u00b14.9]; in Group II: \u22125.8 [\u00b13.2];\n              <jats:italic>P<\/jats:italic>\n              =0.040) and Hamilton Rating Scale for Depression (change in Group I: \u22125.0 [\u00b11.4]; in Group II: \u22123.3 [\u00b11.2];\n              <jats:italic>P<\/jats:italic>\n              =0.002), indicating small-to-medium effect sizes in reducing depression severity with Intensive Language-Action Therapy (\n              <jats:italic>\u03b7<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              \u22640.101). No significant between-group differences emerged on expressive AAT subscales.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Our results confirm the feasibility and potential efficacy of intensive social interaction for treatment of poststroke depression in subacute aphasia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT04318951.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.122.039995","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T09:01:45Z","timestamp":1663664505000},"page":"3530-3537","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Intensive Social Interaction for Treatment of Poststroke Depression in Subacute Aphasia: The CONNECT Trial"],"prefix":"10.1161","volume":"53","clinical-trial-number":[{"clinical-trial-number":"nct04318951","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3957-1495","authenticated-orcid":true,"given":"Benjamin","family":"Stahl","sequence":"first","affiliation":[{"name":"Faculty of Science, Medical School Berlin, Germany (B.S.)."},{"name":"Department of Neurology, University Medicine Greifswald, Germany (B.S., G.L., A.F.)."},{"name":"Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (B.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2330-523X","authenticated-orcid":true,"given":"Saskia","family":"Millrose","sequence":"additional","affiliation":[{"name":"Department of Psychology, Freie Universit\u00e4t Berlin, Germany (S.M.)."},{"name":"Median-Klinik Berlin-Kladow, Germany (S.M., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7115-307X","authenticated-orcid":true,"given":"Petra","family":"Denzler","sequence":"additional","affiliation":[{"name":"Median-Klinik Berlin-Kladow, Germany (S.M., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1809-6376","authenticated-orcid":true,"given":"Guglielmo","family":"Lucchese","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medicine Greifswald, Germany (B.S., G.L., A.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-6267","authenticated-orcid":true,"given":"Frank","family":"Jacobi","sequence":"additional","affiliation":[{"name":"Psychologische Hochschule Berlin, Germany (F.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1475-5872","authenticated-orcid":true,"given":"Agnes","family":"Fl\u00f6el","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medicine Greifswald, Germany (B.S., G.L., A.F.)."},{"name":"German Centre for Neurodegenerative Diseases, Rostock and Greifswald, Germany (A.F.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","first-page":"157","volume-title":"In: Psychology of Depression: Contemporary Theory and Research","author":"Lewinsohn PM","year":"1974","unstructured":"Lewinsohn, PM. 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