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Few studies have provided adequate explanations for the mechanisms underlying the molecular alterations that produce a more permeable gut and perturbed gut microbiota after stroke. A dysregulation in the production of matrix MMP-7 (metalloproteinase-7) may play a critical role in the progression of gut permeability after stroke. By cleaving junctional and extracellular matrix proteins, MMP-7 is capable of compromising gut barrier integrity. Because of MMP-7\u2019s unique abundance in the small intestine and its capacity to be induced in states of bacterial invasion and inflammation, along with its unique degradative capability, MMP-7 may be crucially important to the progression of gut permeability after ischemic stroke.<\/jats:p>","DOI":"10.1161\/strokeaha.122.040144","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T09:00:18Z","timestamp":1659085218000},"page":"3238-3242","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["An Unexplored Role for MMP-7 (Matrix Metalloproteinase-7) in Promoting Gut Permeability After Ischemic Stroke"],"prefix":"10.1161","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-4381","authenticated-orcid":true,"given":"Jonathan","family":"Larochelle","sequence":"first","affiliation":[{"name":"Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-7207","authenticated-orcid":true,"given":"Changjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-7423","authenticated-orcid":true,"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3631-1989","authenticated-orcid":true,"given":"Eduardo","family":"Candelario-Jalil","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-110"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.038867"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113508"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19899577"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0421-2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12980"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4194"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100952"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.316448"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02435-9"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000450926"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196174"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S268105"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323263"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam9949"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00136.2018"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111817"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00518"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.148.6.1305"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107121200"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00587"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20060263"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5437.113"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni797"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.08.021"},{"key":"e_1_3_3_27_2","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.4049\/jimmunol.154.12.6484","article-title":"Matrilysin expression by human mononuclear phagocytes and its regulation by cytokines and hormones.","volume":"154","author":"Busiek DF","year":"1995","unstructured":"Busiek, DF, Baragi, V, Nehring, LC, Parks, WC, Welgus, HG. 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