{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:56:17Z","timestamp":1781661377479,"version":"3.54.5"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>\n              CYP2B6 (cytochrome P450 subfamily IIB polypeptide 6), encoded by the\n              <jats:italic>CYP2B6<\/jats:italic>\n              gene, is a critical enzyme involved in clopidogrel metabolism. However, the association between\n              <jats:italic>CYP2B6<\/jats:italic>\n              polymorphisms and the efficacy of clopidogrel in minor stroke or transient ischemic attack for secondary stroke prevention remains unclear.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>\n              Based on CHANCE (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) randomized clinical trial of aspirin plus clopidogrel versus aspirin alone, we investigated the role of\n              <jats:italic>CYP2B6<\/jats:italic>\n              polymorphisms and the efficacy of clopidogrel in patients with minor stroke or transient ischemic attack in China from October 2009 to July 2012. A total of 2853 patients were successfully genotyped for\n              <jats:italic>CYP2B6<\/jats:italic>\n              -516G&gt;T, rs3745274 and\n              <jats:italic>CYP2B6<\/jats:italic>\n              -1456 T&gt;C, rs2054675. The primary efficacy and safety outcomes were new stroke and any bleeding within 90 days.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Among the 2853 patients, 32.8% were identified as the carriers of the\n              <jats:italic>CYP2B6<\/jats:italic>\n              -516 GT\/TT or -1456 TC\/CC genotype. The incidences of 90-day new stroke in aspirin plus clopidogrel and aspirin alone groups were 7.1% versus 11.3% among noncarriers, respectively; and 9.7% versus 12.2% among carriers, respectively. The efficacy of aspirin plus clopidogrel versus aspirin alone was not significantly different (\n              <jats:italic>P<\/jats:italic>\n              interaction=0.29) in noncarriers (adjusted hazard ratio, 0.61 [95% CI, 0.45\u20130.83]) compared to carriers (adjusted hazard ratio, 0.80 [95% CI, 0.54\u20131.18]). The incidence (n=51) of 90-day any bleeding in aspirin plus clopidogrel and aspirin alone groups were 2.2% (21 bleeds) versus 1.9% (18 bleeds) among noncarriers (adjusted hazard ratio, 1.11 [95% CI, 0.59\u20132.09]) and 1.9% (9 bleeds) versus 0.7% (3 bleeds) among carriers (adjusted hazard ratio, 3.23 [95% CI, 0.86\u201312.12]). Similar findings were observed during the 1-year follow-up.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>\n              In this post hoc analysis of the CHANCE trial, we did not observe a significant difference in the efficacy of aspirin plus clopidogrel compared with aspirin in carriers versus noncarriers of\n              <jats:italic>CYP2B6<\/jats:italic>\n              -516 GT\/TT or -1456 TC\/CC genotype. Our results suggest that both carriers and noncarriers suffering from a minor stroke are likely to benefit from aspirin plus clopidogrel treatment over aspirin monotherapy for secondary prevention.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT00979589.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.122.040507","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T09:42:17Z","timestamp":1685698937000},"page":"1770-1776","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Association Between\n            <i>CYP2B6<\/i>\n            Polymorphisms and Efficacy of Clopidogrel in Minor Stroke or Transient Ischemic Attack"],"prefix":"10.1161","volume":"54","clinical-trial-number":[{"clinical-trial-number":"nct00979589","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Xin","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.Q., H.G., Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (X.Q., H.G., Yingyu Jiang, Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Genetic Networks, Institute of Genetics and Developmental Biology (Y.Z., X.W.), Chinese Academy of Sciences, Shanghai."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1608-1856","authenticated-orcid":true,"given":"Hongqiu","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.Q., H.G., Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (X.Q., H.G., Yingyu Jiang, Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (X.Q., H.G., Yingyu Jiang, Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3082-6789","authenticated-orcid":true,"given":"Yuesong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.Q., H.G., Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (X.Q., H.G., Yingyu Jiang, Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7700-6054","authenticated-orcid":true,"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.Q., H.G., Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (X.Q., H.G., Yingyu Jiang, Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.Q., H.G., Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (X.Q., H.G., Yingyu Jiang, Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2725-2788","authenticated-orcid":true,"given":"Yilong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.Q., H.G., Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (X.Q., H.G., Yingyu Jiang, Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8345-5147","authenticated-orcid":true,"given":"Xingquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.Q., H.G., Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (X.Q., H.G., Yingyu Jiang, Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.Q., H.G., Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (X.Q., H.G., Yingyu Jiang, Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujie","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Genetic Networks, Institute of Genetics and Developmental Biology (Y.Z., X.W.), Chinese Academy of Sciences, Shanghai."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-2341","authenticated-orcid":true,"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.Q., H.G., Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (X.Q., H.G., Yingyu Jiang, Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."},{"name":"Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing (Yongjun Wang, Z.L.)."},{"name":"Center for Excellence in Brain Science and Intelligence Technology (Yongjun Wang), Chinese Academy of Sciences, Shanghai."},{"name":"Clinical Center for Precision Medicine in Stroke, Capital Medical University, Beijing, China (Yongjun Wang)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4713-5418","authenticated-orcid":true,"given":"Zixiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.Q., H.G., Y.P., Yong Jiang, X.M., Yilong Wang, X.Z., H.L., Yongjun Wang, Z.L.)."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (X.Q., H.G., Yingyu Jiang, Y.P., Yong Jiang, 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