{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:49:25Z","timestamp":1790423365147,"version":"4.1.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>There are limited data regarding the prevalence of distinct clinical, neuroimaging and genetic markers among patients diagnosed with cerebral amyloid angiopathy\u2013related inflammation (CAA-ri). We sought to determine the prevalence of clinical, radiological, genetic and cerebrospinal fluid biomarker findings in patients with CAA-ri.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              A systematic review and meta-analysis of published studies including patients with CAA-ri was conducted to determine the prevalence of clinical, neuroimaging, genetic and cerebrospinal fluid biomarker findings. Subgroup analyses were performed based on (1) prospective or retrospective study design and (2) CAA-ri diagnosis with or without available biopsy. We pooled the prevalence rates using random-effects models and assessed the heterogeneity using Cochran-Q and I\n              <jats:sup>2<\/jats:sup>\n              -statistics.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              We identified 4 prospective and 17 retrospective cohort studies comprising 378 patients with CAA-ri (mean age, 71.5 years; women, 52%). The pooled prevalence rates were as follows: cognitive decline at presentation 70% ([95% CI, 54%\u201384%]; I\n              <jats:sup>2<\/jats:sup>\n              =82%), focal neurological deficits 55% ([95% CI, 40%\u201370%]; I\n              <jats:sup>2<\/jats:sup>\n              =82%), encephalopathy 54% ([95% CI, 39%\u201368%]; I\n              <jats:sup>2<\/jats:sup>\n              =43%), seizures 37% ([95% CI, 27%\u201349%]; I\n              <jats:sup>2<\/jats:sup>\n              =65%), headache 31% ([95% CI, 22%\u201342%]; I\n              <jats:sup>2<\/jats:sup>\n              =58%), T2\/fluid-attenuated inversion recovery-hyperintense white matter lesions 98% ([95% CI, 93%\u2013100%]; I\n              <jats:sup>2<\/jats:sup>\n              =44%), lobar cerebral microbleeds 96% ([95% CI, 92%\u201399%]; I\n              <jats:sup>2<\/jats:sup>\n              =25%), gadolinium enhancing lesions 54% ([95% CI, 42%\u201366%]; I\n              <jats:sup>2<\/jats:sup>\n              =62%), cortical superficial siderosis 51% ([95% CI, 34%\u201368%]; I\n              <jats:sup>2<\/jats:sup>\n              =77%) and lobar macrohemorrhage 40% ([95% CI, 11%\u201373%]; I\n              <jats:sup>2<\/jats:sup>\n              =88%). The prevalence rate of the ApoE (Apolipoprotein E) \u03b54\/\u03b54 genotype was 34% ([95% CI, 17%\u201353%]; I\n              <jats:sup>2<\/jats:sup>\n              =76%). Subgroup analyses demonstrated no differences in these prevalence rates based on study design and diagnostic strategy.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Cognitive decline was the most common clinical feature. Hyperintense T2\/fluid-attenuated inversion recovery white matter lesions and lobar cerebral microbleeds were by far the most prevalent neuroimaging findings. Thirty-four percent of patients with CAA-ri have homozygous ApoE \u03b54\/\u03b54 genotype and scarce data exist regarding the cerebrospinal fluid biomarkers and its significance in these patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.122.040671","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T10:00:20Z","timestamp":1669888820000},"page":"178-188","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis"],"prefix":"10.1161","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-2610","authenticated-orcid":true,"given":"Aikaterini","family":"Theodorou","sequence":"first","affiliation":[{"name":"Second Department of Neurology (A.T., L.P., C.Z., G.P.P., G.T.), National &amp; Kapodistrian University of Athens, \u201cAttikon\u201d University Hospital, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7757-609X","authenticated-orcid":true,"given":"Lina","family":"Palaiodimou","sequence":"additional","affiliation":[{"name":"Second Department of Neurology (A.T., L.P., C.Z., G.P.P., G.T.), National &amp; Kapodistrian University of Athens, \u201cAttikon\u201d University Hospital, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-8101","authenticated-orcid":true,"given":"Konark","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Neurology, Allegheny Health Network, Pittsburgh, PA (K.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5246-3870","authenticated-orcid":true,"given":"Christina","family":"Zompola","sequence":"additional","affiliation":[{"name":"Second Department of Neurology (A.T., L.P., C.Z., G.P.P., G.T.), National &amp; Kapodistrian University of Athens, \u201cAttikon\u201d University Hospital, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6359-0023","authenticated-orcid":true,"given":"Aristeidis H.","family":"Katsanos","sequence":"additional","affiliation":[{"name":"Division of Neurology, McMaster University\/Population Health Research Institute, Hamilton, Canada (A.H.K., A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-1626","authenticated-orcid":true,"given":"Ashkan","family":"Shoamanesh","sequence":"additional","affiliation":[{"name":"Division of Neurology, McMaster University\/Population Health Research Institute, Hamilton, Canada (A.H.K., A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-9739","authenticated-orcid":true,"given":"Efstathios","family":"Boviatsis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (E.B.), National &amp; Kapodistrian University of Athens, \u201cAttikon\u201d University Hospital, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2957-641X","authenticated-orcid":true,"given":"Efthimios","family":"Dardiotis","sequence":"additional","affiliation":[{"name":"Neurology Department, University Hospital of Larissa, University of Thessaly, Greece (E.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9035-3963","authenticated-orcid":true,"given":"Martha","family":"Spilioti","sequence":"additional","affiliation":[{"name":"First Department of Neurology, AHEPA General Hospital, Aristotle University of Thessaloniki, Greece (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0651-1939","authenticated-orcid":true,"given":"Simona","family":"Sacco","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, via Vetoio, Italy (S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-1861","authenticated-orcid":true,"given":"David J.","family":"Werring","sequence":"additional","affiliation":[{"name":"Stroke Research Centre, UCL Queen Square Institute of Neurology, London, United Kingdom (D.J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5697-6892","authenticated-orcid":true,"given":"Charlotte","family":"Cordonnier","sequence":"additional","affiliation":[{"name":"University Lille, Inserm, CHU Lille, U1172, LilNCog, Lille Neuroscience and Cognition, France 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