{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T18:52:20Z","timestamp":1782759140272,"version":"3.54.5"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Recent evidence suggests that higher CRP (C-reactive protein) levels are associated with lower risk of Alzheimer disease, speculating that CRP might be involved in A\u03b2 clearance mechanisms. Testing this hypothesis, we explored whether genetically proxied CRP levels are also associated with lobar intracerebral hemorrhage (ICH), commonly caused by cerebral amyloid angiopathy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              We used 4 genetic variants within the\n              <jats:italic>CRP<\/jats:italic>\n              gene that explain up to 64% of the variance of circulating CRP levels and explored in 2-sample Mendelian randomization analyses associations with risk of any, lobar, and deep ICH (1545 cases and 1481 controls).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Higher genetically proxied CRP levels were associated with lower odds of lobar ICH (odds ratio per SD increment in CRP, 0.45 [95% CI, 0.25\u20130.73]) but not deep ICH (odds ratio, 0.72 [95% CI, 0.45\u20131.14]). There was evidence of colocalization (posterior probability of association, 72.4%) in the signals for CRP and lobar ICH.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Our results provide supportive evidence that high CRP levels may have a protective role in amyloid-related pathology.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.122.041889","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T18:00:50Z","timestamp":1679940050000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Genetically Proxied CRP (C-Reactive Protein) Levels and Lobar Intracerebral Hemorrhage Risk"],"prefix":"10.1161","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7310-624X","authenticated-orcid":true,"given":"Evangelos Pavlos","family":"Myserlis","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical University of South Carolina, Charleston (E.P.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0053-2002","authenticated-orcid":true,"given":"Christopher D.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine (C.D.A., M.K.G.), Massachusetts General Hospital, Boston."},{"name":"Henry and Alisson McCance Center for Brain Health (C.D.A., M.K.G.), Massachusetts General Hospital, Boston."},{"name":"Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (C.D.A., M.K.G.)."},{"name":"Department of Neurology, Brigham and Women\u2019s Hospital, Boston, MA (C.D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3507-3659","authenticated-orcid":true,"given":"Marios K.","family":"Georgakis","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine (C.D.A., M.K.G.), Massachusetts General Hospital, Boston."},{"name":"Henry and Alisson McCance Center for Brain Health (C.D.A., M.K.G.), Massachusetts General Hospital, Boston."},{"name":"Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (C.D.A., M.K.G.)."},{"name":"Institute for Stroke and Dementia Research (ISD), LMU University Hospital, Ludwig-Maximillians-University, Munich, Germany (M.K.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12568"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.02.012"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30006-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29650-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18236"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n2233"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.119.002872"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319077"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807646"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.034576"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac186"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.122.041889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:03:18Z","timestamp":1715612598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.122.041889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1161\/STROKEAHA.122.041889"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.122.041889","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"2022-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}