{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:06:44Z","timestamp":1789070804295,"version":"build-2803163510"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Diffusion-weighted imaging lesion reversal (DWIR) is frequently observed after mechanical thrombectomy for acute ischemic stroke, but little is known about age-related differences and impact on outcome. We aimed to compare, in patients &lt;80 versus \u226580 years old, (1) the effect of successful recanalization on DWIR and (2) the impact of DWIR on functional outcome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>We retrospectively analyzed data of patients treated for an anterior circulation acute ischemic stroke with large vessel occlusion in 2 French hospitals, who underwent baseline and 24-hour follow-up magnetic resonance imaging, with baseline DWI lesion volume \u226510 cc. The percentage of DWIR (DWIR%), was calculated as follows: DWIR%=(DWIR volume\/baseline DWI volume)\u00d7100. Data on demographics, medical history, and baseline clinical and radiological characteristics were collected.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Among 433 included patients (median age, 68 years), median DWIR% after mechanical thrombectomy was 22% (6\u201335) in patients \u226580, and 19% (interquartile range, 10\u201334) in patients &lt;80 (\n              <jats:italic>P<\/jats:italic>\n              =0.948). In multivariable analyses, successful recanalization after mechanical thrombectomy was associated with higher median DWIR% in both \u226580 (\n              <jats:italic>P<\/jats:italic>\n              =0.004) and &lt;80 (\n              <jats:italic>P<\/jats:italic>\n              =0.002) patients. In subgroup analyses performed on a minority of subjects, collateral vessels status score (n=87) and white matter hyperintensity volume (n=131) were not associated with DWIR% (\n              <jats:italic>P<\/jats:italic>\n              &gt;0.2). In multivariable analyses, DWIR% was associated with increased rates of favorable 3-month outcomes in both \u226580 (\n              <jats:italic>P<\/jats:italic>\n              =0.003) and &lt;80 (\n              <jats:italic>P<\/jats:italic>\n              =0.013) patients; the effect of DWIR% on outcome was not influenced by the age group (\n              <jats:italic>P<\/jats:italic>\n              interaction=0.185)\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>DWIR might be an important and nonage-dependent effect of arterial recanalization, as it seems to beneficially impact 3-month outcomes of both younger and older subjects treated with mechanical thrombectomy for acute ischemic stroke and large vessel occlusion.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.123.042491","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T09:00:25Z","timestamp":1684486825000},"page":"1823-1829","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Diffusion-Weighted Imaging Lesion Reversal in Older Patients With Stroke Treated With Mechanical Thrombectomy"],"prefix":"10.1161","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-2124","authenticated-orcid":true,"given":"Giuseppe","family":"Scopelliti","sequence":"first","affiliation":[{"name":"University of Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience &amp; Cognition, France (G.S., L.P., C.C., H.H., M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0733-0104","authenticated-orcid":true,"given":"Joseph","family":"Benzakoun","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, France (J.B., W.B.H., G.T., C.O., O.N.)."},{"name":"Department of Radiology (J.B., W.B.H., C.O., O.N.), GHU Paris Psychiatrie et Neurosciences, Site Sainte-Anne, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-3623","authenticated-orcid":true,"given":"Wagih","family":"Ben Hassen","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, France (J.B., W.B.H., G.T., C.O., O.N.)."},{"name":"Department of Radiology (J.B., W.B.H., C.O., O.N.), GHU Paris Psychiatrie et Neurosciences, Site Sainte-Anne, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7594-4159","authenticated-orcid":true,"given":"Martin","family":"Bretzner","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Roger Salengro Hospital, CHU Lille, University of Lille, France (M.B., N.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1469-3613","authenticated-orcid":true,"given":"Nicolas","family":"Bricout","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Roger Salengro Hospital, CHU Lille, University of Lille, France (M.B., N.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9772-5192","authenticated-orcid":true,"given":"Laurent","family":"Puy","sequence":"additional","affiliation":[{"name":"University of Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience &amp; Cognition, France (G.S., L.P., C.C., H.H., M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-4095","authenticated-orcid":true,"given":"Guillaume","family":"Turc","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, France (J.B., W.B.H., G.T., C.O., O.N.)."},{"name":"Department of Neurology (G.T.), GHU Paris Psychiatrie et Neurosciences, Site Sainte-Anne, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-9205","authenticated-orcid":true,"given":"Gr\u00e9goire","family":"Boulouis","sequence":"additional","affiliation":[{"name":"Diagnostic and Interventional Neuroradiology Department, University Hospital of Tours, Centre Val de Loire, INSERM U1253 iBrain, France (G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3410-0862","authenticated-orcid":true,"given":"Catherine","family":"Oppenheim","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, France (J.B., W.B.H., G.T., C.O., O.N.)."},{"name":"Department of Radiology (J.B., W.B.H., C.O., O.N.), GHU Paris Psychiatrie et Neurosciences, Site Sainte-Anne, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9544-379X","authenticated-orcid":true,"given":"Olivier","family":"Naggara","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, France (J.B., W.B.H., G.T., C.O., O.N.)."},{"name":"Department of Radiology (J.B., W.B.H., C.O., O.N.), GHU Paris Psychiatrie et Neurosciences, Site Sainte-Anne, 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