{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:55:23Z","timestamp":1789779323626,"version":"4.0.1"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Sleep-disordered breathing (SDB) and atrial fibrillation (AF) are highly prevalent in patients with stroke and are recognized as independent risk factors for stroke. Little is known about the impact of comorbid SDB and AF on long-term outcomes after stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>In this prospective cohort study, 353 patients with acute ischemic stroke or transient ischemic attacks were analyzed. Patients were screened for SDB by respiratory polygraphy during acute hospitalization. Screening for AF was performed using a 7-day ECG up to 3\u00d7 in the first 6 months. Follow-up visits were scheduled at 1, 3, 12, 24, and 36 months poststroke. Cox regression models adjusted for various factors (age, sex, body mass index, hypertension, diabetes, dyslipidemia, and heart failure) were used to assess the impact of comorbid SDB and AF on subsequent death or cerebro-cardiovascular events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Among 353 patients (299 ischemic stroke and 54 transient ischemic attacks), median age, 67 (interquartile range, 57\u201374) years with 63% males. Moderate-to-severe SDB (apnea-hypopnea index score, \u226515\/h) was present in 118 (33.4%) patients. Among the 56 (15.9%) patients with AF, 28 had comorbid moderate-to-severe SDB and AF. Over 36 months, there were 12 deaths and 67 recurrent cerebro-cardiovascular events. Patients with comorbid moderate-to-severe SDB and AF had a higher risk of subsequent death or cerebro-cardiovascular events compared with those with only moderate-to-severe SDB without AF (hazard ratio, 2.49 [95% CI, 1.18\u20135.24]) and to those without moderate-to-severe SDB or AF (hazard ratio, 2.25 [95% CI, 1.12\u20134.50]). However, no significant difference was found between the comorbid moderate-to-severe SDB and AF group and the group with only AF without moderate-to-severe SDB (hazard ratio, 1.64 [95% CI, 0.62\u20134.36]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Comorbid moderate-to-severe SDB and AF significantly increase the risk of long-term mortality or recurrent cerebro-cardiovascular events after acute ischemic stroke. Considering both conditions as cumulative and modifiable cerebro-cardiovascular risk factors is of interest for the management of acute stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT02559739.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.123.042856","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T05:00:37Z","timestamp":1706245237000},"page":"586-594","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of Comorbid Sleep-Disordered Breathing and Atrial Fibrillation on the Long-Term Outcome After Ischemic Stroke"],"prefix":"10.1161","volume":"55","clinical-trial-number":[{"clinical-trial-number":"nct02559739","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7873-9169","authenticated-orcid":true,"given":"Xiaoli","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology (X.Y., J.L., M.D., S.B.D., C.B., M.H.S., C.L.A.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."},{"name":"Interdisciplinary Sleep-Wake-Epilepsy-Center (X.Y., J.L., M.D., S.B.D., A.-K.B., M.H.S., C.L.A.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9951-4807","authenticated-orcid":true,"given":"Julian","family":"Lippert","sequence":"additional","affiliation":[{"name":"Department of Neurology (X.Y., J.L., M.D., S.B.D., C.B., M.H.S., C.L.A.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."},{"name":"Interdisciplinary Sleep-Wake-Epilepsy-Center (X.Y., J.L., M.D., S.B.D., A.-K.B., M.H.S., C.L.A.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1627-2882","authenticated-orcid":true,"given":"Martijn","family":"Dekkers","sequence":"additional","affiliation":[{"name":"Department of Neurology (X.Y., J.L., M.D., S.B.D., C.B., M.H.S., C.L.A.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."},{"name":"Interdisciplinary Sleep-Wake-Epilepsy-Center (X.Y., J.L., M.D., S.B.D., A.-K.B., M.H.S., C.L.A.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2348-6918","authenticated-orcid":true,"given":"Sebastien","family":"Baillieul","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University, HP2 Laboratory, INSERM U1300 and Grenoble Alpes University Hospital, France (S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7247-0760","authenticated-orcid":true,"given":"Simone B.","family":"Duss","sequence":"additional","affiliation":[{"name":"Department of Neurology (X.Y., J.L., M.D., S.B.D., C.B., M.H.S., C.L.A.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-8415","authenticated-orcid":true,"given":"Tobias","family":"Reichlin","sequence":"additional","affiliation":[{"name":"Department of Cardiology (T.R.), Inselspital, Bern University Hospital, University of Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6724-8794","authenticated-orcid":true,"given":"Anne-Kathrin","family":"Brill","sequence":"additional","affiliation":[{"name":"Interdisciplinary Sleep-Wake-Epilepsy-Center (X.Y., J.L., M.D., S.B.D., A.-K.B., M.H.S., C.L.A.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."},{"name":"Department of Pulmonary Medicine and Allergology (A.-K.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-5468","authenticated-orcid":true,"given":"Corrado","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Department of Neurology (X.Y., J.L., M.D., S.B.D., C.B., M.H.S., C.L.A.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3299-1318","authenticated-orcid":true,"given":"Markus H.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Neurology (X.Y., J.L., M.D., S.B.D., C.B., M.H.S., C.L.A.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."},{"name":"Interdisciplinary Sleep-Wake-Epilepsy-Center (X.Y., J.L., M.D., S.B.D., A.-K.B., M.H.S., C.L.A.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-0245","authenticated-orcid":true,"given":"Claudio L.A.","family":"Bassetti","sequence":"additional","affiliation":[{"name":"Department of Neurology (X.Y., J.L., M.D., S.B.D., C.B., M.H.S., C.L.A.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."},{"name":"Interdisciplinary Sleep-Wake-Epilepsy-Center (X.Y., J.L., M.D., S.B.D., A.-K.B., M.H.S., C.L.A.B.), Inselspital, Bern University Hospital, University of Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00321-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.029847"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023807"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01104-2019"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011465"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.22.8.983"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000166053.83476.4a"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.858381"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccep.2020.10.003"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0229"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000136587.68725.8E"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.077"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.10.011"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2022.2036606"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.038"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.3514"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.04.005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.31.4.858"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.24.1.35"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18236"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2015.07.031"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.03.053"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4901.101760"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000018948.95175.03"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-016-1387-z"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200808-1341OC"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.70"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.111.964783"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6884"},{"key":"e_1_3_3_32_2","first-page":"615","article-title":"Sleep disorderd breathing and recurrence of cerebrovascular events, case-fatality, and functional outcome in patients with ischemic stroke or transient ischemic attack.","volume":"59","author":"Rola R","year":"2008","unstructured":"Rola, R, Jarosz, H, Wierzbicka, A, Wichniak, A, Richter, P, Ryglewicz, D, Jernajczyk, W. Sleep disorderd breathing and recurrence of cerebrovascular events, case-fatality, and functional outcome in patients with ischemic stroke or transient ischemic attack. J Physiol Pharmacol. 2008;59:615\u2013621.","journal-title":"J Physiol Pharmacol"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000208215.49243.c3"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001599"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5146"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.09.007"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2015.12.002"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.12.052"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025384"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.03.005"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006904"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-009-0325-8"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12070"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy624"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005262"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.123.042856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:29:20Z","timestamp":1715599760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.123.042856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1161\/STROKEAHA.123.042856"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.123.042856","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}