{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:05:50Z","timestamp":1793639150116,"version":"4.5.1"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Estimates of attributable costs of stroke are scarce, as most prior studies do not account for the baseline health care costs in people at risk of stroke. We estimated the attributable costs of stroke in a universal health care setting and their variation across stroke types and several social determinants of health.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>We undertook a population-based administrative database-derived matched retrospective cohort study in Ontario, Canada. Community-dwelling adults aged \u226540 years with a stroke between 2003 and 2018 were matched (1:1) on demographics and comorbidities with controls without stroke. Using a difference-in-differences approach, we estimated the mean 1-year direct health care costs attributable to stroke from a public health care payer perspective, accounting for censoring with a weighted available sample estimator. We described health sector\u2013specific costs and reported variation across stroke type and social determinants of health.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>The mean 1-year attributable costs of stroke were Canadian dollars 33\u2005522 (95% CI, $33\u2005231\u2013$33\u2005813), with higher costs for intracerebral hemorrhage ($40\u2005244; $39\u2005193\u2013$41\u2005294) than ischemic stroke ($32\u2005547; $32\u2005252\u2013$32\u2005843). Most of these costs were incurred in acute care hospitals ($15\u2005693) and rehabilitation facilities ($7215). Compared with all patients with stroke, the mean attributable costs were higher among immigrants ($40\u2005554; $39\u2005316\u2013$41\u2005793), those aged &lt;65 years ($35\u2005175; $34\u2005533\u2013$35\u2005818), and those residing in low-income neighborhoods ($34\u2005687; $34\u2005054\u2013$35\u2005320) and lower among rural residents ($29\u2005047; $28\u2005362\u2013$29\u2005731).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Our findings of high attributable costs of stroke, especially in immigrants, younger patients, and residents of low-income neighborhoods, can be used to evaluate potential health care cost savings associated with different primary stroke prevention strategies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.123.043369","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T09:00:26Z","timestamp":1697101226000},"page":"2824-2831","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Attributable Costs of Stroke in Ontario, Canada and Their Variation by Stroke Type and Social Determinants of Health"],"prefix":"10.1161","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2953-2540","authenticated-orcid":true,"given":"Manav V.","family":"Vyas","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Medicine (M.V.V., A.Y.X.Y.), University of Toronto, Canada."},{"name":"Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health (M.V.V., C.d.O., P.C.A., A.Y.X.Y., M.K.K.), University of Toronto, Canada."},{"name":"Division of Neurology, Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital-Unity Health Toronto, Canada (M.V.V.)."},{"name":"ICES, Toronto, Canada (M.V.V., J.F., C.d.O., P.C.A., A.Y.X.Y., M.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-0987","authenticated-orcid":true,"given":"Jiming","family":"Fang","sequence":"additional","affiliation":[{"name":"ICES, Toronto, Canada (M.V.V., J.F., C.d.O., P.C.A., A.Y.X.Y., M.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3961-6008","authenticated-orcid":true,"given":"Claire","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health (M.V.V., C.d.O., P.C.A., A.Y.X.Y., M.K.K.), University of Toronto, Canada."},{"name":"Health Economics, Centre for Addictions and Mental Health, Toronto, Canada (C.d.O.)."},{"name":"ICES, Toronto, Canada (M.V.V., J.F., C.d.O., P.C.A., A.Y.X.Y., M.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3337-233X","authenticated-orcid":true,"given":"Peter C.","family":"Austin","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health (M.V.V., C.d.O., P.C.A., A.Y.X.Y., M.K.K.), University of Toronto, Canada."},{"name":"ICES, Toronto, Canada (M.V.V., J.F., C.d.O., P.C.A., A.Y.X.Y., M.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7276-9551","authenticated-orcid":true,"given":"Amy Y.X.","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine (M.V.V., A.Y.X.Y.), University of Toronto, Canada."},{"name":"Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health (M.V.V., C.d.O., P.C.A., A.Y.X.Y., M.K.K.), University of Toronto, Canada."},{"name":"ICES, Toronto, Canada (M.V.V., J.F., C.d.O., P.C.A., A.Y.X.Y., M.K.K.)."},{"name":"Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada (A.Y.X.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3444-9928","authenticated-orcid":true,"given":"Moira K.","family":"Kapral","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health (M.V.V., C.d.O., P.C.A., A.Y.X.Y., M.K.K.), University of Toronto, Canada."},{"name":"Division of General Internal Medicine, Department of Medicine (M.K.K.), University of Toronto, Canada."},{"name":"ICES, Toronto, Canada (M.V.V., J.F., C.d.O., P.C.A., A.Y.X.Y., M.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-018-4591-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308413"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.116643"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/2396987319883160"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/s0317167100015638"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-021-06669-w"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012676"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-6773.2008.00909.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.03.001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2016.278"},{"key":"e_1_3_3_12_2","volume-title":"Guidelines on Person-Level Costing Using Administrative Databases in Ontario","author":"Wodchis WP","year":"2013","unstructured":"Wodchis, WP, Bushmeneva, K, Nikitovic, M, McKillop, I. Guidelines on Person-Level Costing Using Administrative Databases in Ontario. 2013. Toronto: Health System Performance Research Network."},{"key":"e_1_3_3_13_2","unstructured":"Inflation calculator. Assessed June 23 2023. https:\/\/www.bankofcanada.ca\/rates\/related\/inflation-calculator\/"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.16153"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-016-0229-2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012777"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S31552"},{"key":"e_1_3_3_18_2","unstructured":"Canadian Chronic Disease Surveillance System (CCDSS). Assessed June 23 2023. https:\/\/health-infobase.canada.ca\/ccdss\/data-tool\/"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.529776"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2022.04.055"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003276"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-018-0984-0"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027919"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008615"},{"key":"e_1_3_3_25_2","unstructured":"Vyas MV. The association between immigration status and stroke incidence care and outcomes. Doctoral Thesis. 2021. University of Toronto."},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.02.019"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2020.9"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.040869"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs0102.101169"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2018.12.021"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826aac9b"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030423"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181a819a1"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.22.2623"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac245"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022161"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-018-3696-3"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1159\/000454730"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30665-2"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.123.043369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T13:13:57Z","timestamp":1749042837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.123.043369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1161\/STROKEAHA.123.043369"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.123.043369","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}