{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:19:21Z","timestamp":1789705161187,"version":"4.0.1"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Integrity of the corticospinal tract (CST) is an important biomarker for upper limb motor function following stroke. However, when structurally compromised, other tracts may become relevant for compensation or recovery of function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We used the ENIGMA Stroke Recovery data set, a multicenter, retrospective, and cross-sectional collection of patients with upper limb impairment during the chronic phase of stroke to test the relevance of tracts in individuals with less and more severe (laterality index of CST fractional anisotropy \u22650.25) CST damage in an observational study design. White matter integrity was quantified using fractional anisotropy for the CST, the superior longitudinal fascicle, and the callosal fibers interconnecting the primary motor cortices between hemispheres. Optic radiations served as a control tract as they have no a priori relevance for the motor system. Pearson correlation was used for testing correlation with upper limb motor function (Fugl-Meyer upper extremity).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      From 1235 available data sets, 166 were selected (by imaging, Fugl-Meyer upper extremity, covariates, stroke location, and stage) for analyses. Only individuals with severe CST damage showed a positive association of fractional anisotropy in both callosal fibers interconnecting the primary motor cortices (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      [21]=0.49;\n                      <jats:italic toggle=\"yes\">P=<\/jats:italic>\n                      0.025) and superior longitudinal fascicle (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      [21]=0.51;\n                      <jats:italic toggle=\"yes\">P=0<\/jats:italic>\n                      .018) with Fugl-Meyer upper extremity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Our data support the notion that individuals with more severe damage of the CST depend on residual pathways for achieving better upper limb outcome than those with less affected CST.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.123.043713","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T05:08:52Z","timestamp":1689743332000},"page":"2438-2441","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["White Matter Integrity and Chronic Poststroke Upper Limb Function: An ENIGMA Stroke Recovery Analysis"],"prefix":"10.1161","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8620-966X","authenticated-orcid":true,"given":"Martin","family":"Domin","sequence":"first","affiliation":[{"name":"Functional Imaging Unit, Diagnostic and Neuroradiology, University Hospital Greifswald, Germany (M.D., P.H., M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7129-6684","authenticated-orcid":true,"given":"Brenton","family":"Hordacre","sequence":"additional","affiliation":[{"name":"IIMPACT in Health, University of South Australia, Adelaide (B.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-384X","authenticated-orcid":true,"given":"Pavel","family":"Hok","sequence":"additional","affiliation":[{"name":"Functional Imaging Unit, Diagnostic and Neuroradiology, University Hospital Greifswald, Germany (M.D., P.H., M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-4549","authenticated-orcid":true,"given":"Lara A.","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, University of British Columbia, Vancouver, Canada (L.A.B., J.W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-3490","authenticated-orcid":true,"given":"Adriana B.","family":"Conforto","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, S\u00e3o Paulo University, Brazil (A.B.C.)."},{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo, Brazil (A.B.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-1689","authenticated-orcid":true,"given":"Justin W.","family":"Andrushko","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, University of British Columbia, Vancouver, Canada (L.A.B., J.W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9897-9867","authenticated-orcid":true,"given":"Michael R.","family":"Borich","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Emory School of Medicine, Atlanta, GA (M.R.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-1303","authenticated-orcid":true,"given":"Richard C.","family":"Craddock","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Medicine (R.C.C.), The University of Texas at Austin."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1983-3008","authenticated-orcid":true,"given":"Miranda R.","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Chan Division of Occupational Science and Occupational Therapy (M.R.D., B.P.L., S.-L.L.), University of Southern California, Los Angeles."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4809-6115","authenticated-orcid":true,"given":"Adrienne N.","family":"Dula","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dell Medical School at The University of Texas Austin (A.N.D., S.J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3125-7979","authenticated-orcid":true,"given":"Steven J.","family":"Warach","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dell Medical School at The University of Texas Austin (A.N.D., S.J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3151-8235","authenticated-orcid":true,"given":"Steven A.","family":"Kautz","sequence":"additional","affiliation":[{"name":"Department of Health Sciences &amp; Research (S.A.K., N.J.S., S.S.), Medical University of South Carolina, Charleston."},{"name":"Ralph H. Johnson VA Health Care System, Charleston, SC (S.A.K., N.J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7626-9020","authenticated-orcid":true,"given":"Bethany P.","family":"Lo","sequence":"additional","affiliation":[{"name":"Chan Division of Occupational Science and Occupational Therapy (M.R.D., B.P.L., S.-L.L.), University of Southern California, Los Angeles."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-7180","authenticated-orcid":true,"given":"Christian","family":"Schranz","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences (C.S., N.J.S.), Medical University of South Carolina, Charleston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6446-5905","authenticated-orcid":true,"given":"Na Jin","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Health Sciences &amp; Research (S.A.K., N.J.S., S.S.), Medical University of South Carolina, Charleston."},{"name":"Department of Rehabilitation Sciences (C.S., N.J.S.), Medical University of South Carolina, Charleston."},{"name":"Ralph H. Johnson VA Health Care System, Charleston, SC (S.A.K., N.J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5651-919X","authenticated-orcid":true,"given":"Shraddha","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Health Sciences &amp; Research (S.A.K., N.J.S., S.S.), Medical University of South Carolina, Charleston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0163-0466","authenticated-orcid":true,"given":"Kristin A.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine &amp; Rehabilitation (K.A.W.), The University of Texas at Austin."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1953-8663","authenticated-orcid":true,"given":"Artemis","family":"Zavaliangos-Petropulu","sequence":"additional","affiliation":[{"name":"Brain Mapping Center, Department of Neurology, Geffen School of Medicine, University of California, Los Angeles (A.Z.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark &amp; 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