{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:11:56Z","timestamp":1786122716271,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Cerebellar intracerebral hemorrhage (cICH) is often attributed to hypertension or cerebral amyloid angiopathy (CAA). However, deciphering the exact etiology can be challenging. A recent study reported a topographical etiologic relationship with superficial cICH secondary to CAA. We aimed to reexamine this relationship between topography and etiology in a separate cohort of patients and using the most recent Boston criteria version 2.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We performed a retrospective analysis of consecutive patients with primary cICH admitted to a tertiary academic center between 2000 and 2022. cICH location on brain computed tomography\/magnetic resonance imaging scan(s) was divided into strictly superficial (cortex, surrounding white matter, vermis) versus deep (cerebellar nuclei, deep white matter, peduncular region) or mixed (both regions). Magnetic resonance imaging was rated for markers of cerebral small vessel disease. We assigned possible\/probable versus absent CAA using Boston criteria 2.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      We included 197 patients; 106 (53.8%) were females, median age was 74 (63\u201382) years. Fifty-six (28%) patients had superficial cICH and 141 (72%) deep\/mixed cICH. Magnetic resonance imaging was available for 112 (57%) patients (30 [26.8%] with superficial and 82 [73.2%] with deep\/mixed cICH). Patients with superficial cICH were more likely to have possible\/probable CAA (48.3% versus 8.6%; odds ratio [OR], 11.43 [95% CI, 3.26\u201340.05];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), strictly lobar cerebral microbleeds (51.7% versus 6.2%; OR, 14.18 [95% CI, 3.98\u201350.50];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), and cortical superficial siderosis (13.8% versus 1.2%; OR, 7.70 [95% CI, 0.73\u201380.49];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.08). Patients with deep\/mixed cICH were more likely to have deep\/mixed cerebral microbleeds (59.2% versus 3.4%; OR, 41.39 [95% CI, 5.01\u2013341.68];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001), lacunes (54.9% versus 17.2%; OR, 6.14 [95% CI, 1.89\u201319.91];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.002), severe basal ganglia enlarged perivascular spaces (36.6% versus 7.1%; OR, 7.63 [95% CI, 1.58\u201336.73];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01), hypertension (84.4% versus 62.5%; OR, 3.43 [95% CI, 1.61 to \u22127.30];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001), and higher admission systolic blood pressure (172 [146\u2013200] versus 146 [124\u2013158] mm\u2009Hg,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Our results suggest that superficial cICH is strongly associated with CAA whereas deep\/mixed cICH is strongly associated with hypertensive arteriopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.123.044271","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:00:29Z","timestamp":1697432429000},"page":"3074-3080","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Etiology of Primary Cerebellar Intracerebral Hemorrhage Based on Topographic Localization"],"prefix":"10.1161","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6764-129X","authenticated-orcid":true,"given":"Diego","family":"Incontri","sequence":"first","affiliation":[{"name":"Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.)."},{"name":"Centro de Investigaci\u00f3n en Ciencias de la Salud (CICSA), FCS, Universidad An\u00e1huac M\u00e9xico Campus Norte, Av. Universidad An\u00e1huac No. 46, Col. Lomas An\u00e1huac, Huixquilucan, CP 52786, Edo. de M\u00e9xico, M\u00e9xico (D.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9969-9362","authenticated-orcid":true,"given":"Sarah","family":"Marchina","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6886-1112","authenticated-orcid":true,"given":"Alexander","family":"Andreev","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-9045","authenticated-orcid":true,"given":"Jia-Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Heistand","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipa","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1936-3173","authenticated-orcid":true,"given":"Magdy","family":"Selim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8521-0036","authenticated-orcid":true,"given":"Vasileios-Arsenios","family":"Lioutas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (D.I., S.M., A.A., M.W., J.-Y.W., D.L., E.C.H., F.C., M.S., V.-A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2201449"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.14673"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027969"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.024148"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197107000-00015"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0025-6196(25)18993-3","article-title":"Clinicopathologic studies of primary cerebral amyloid angiopathy.","volume":"54","author":"Okazaki H","year":"1979","unstructured":"Okazaki, H, Reagan, TJ, Campbell, RJ. 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