{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T11:24:12Z","timestamp":1793186652563,"version":"4.5.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Lacunes are associated with cognitive impairment. We sought to identify strategic lacune locations associated with mild cognitive impairment (MCI) and subtypes of MCI among older adults, and further to examine the role of white matter hyperintensities and perivascular spaces in the association.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>This population-based cross-sectional study included 1230 dementia-free participants in the brain magnetic resonance imaging substudy (2018\u20132020) in MIND-China (Multimodal Interventions to Delay Dementia and Disability in Rural China). Lacunes were visually identified in frontal lobe, parieto-occipital lobe, temporal lobe, insula, basal ganglia, thalamus, cerebellum, and brainstem. MCI, amnestic MCI (aMCI), and nonamnestic MCI (naMCI) were defined following the Petersen\u2019s criteria. Data were analyzed using logistic regression models.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Of the 1230 participants (age, \u226560 years; mean age, 69.40; SD, 4.30 years; 58.5% women), lacunes were detected in 357 people and MCI was defined in 286 individuals, including 243 with aMCI and 43 with naMCI. Lacunes in the supratentorial area, internal capsula, putamen\/pallidum, and insula was significantly associated with increased odds ratio of MCI (multivariable-adjusted odds ratio ranged 1.40\u20133.21; <jats:italic toggle=\"yes\">P<\/jats:italic>&lt;0.05) and aMCI (multivariable-adjusted odds ratio ranged 1.46\u20133.36; <jats:italic toggle=\"yes\">P<\/jats:italic>&lt;0.05), whereas lacunes in the infratentorial area and brainstem were significantly associated with naMCI (multivariable-adjusted odds ratio ranged 2.68\u20133.46; <jats:italic toggle=\"yes\">P<\/jats:italic>&lt;0.01). Furthermore, the associations of lacunes in insula and internal capsula with MCI and aMCI, as well as the associations of lacunes in infratentorial area and brainstem with naMCI were present independent of white matter hyperintensities volume and perivascular spaces number.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Lacunes in the internal capsula, putamen\/pallidum, insula, and brainstem may represent the strategic lacunes that are independently associated with MCI, aMCI, or naMCI in Chinese older adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>URL: https:\/\/www.chictr.org.cn; Unique identifier: ChiCTR1800017758.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.123.044469","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T09:00:29Z","timestamp":1711011629000},"page":"1288-1298","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Strategic Lacunes Associated With Mild Cognitive Impairment in Rural Chinese Older Adults: A Population-Based Study"],"prefix":"10.1161","volume":"55","clinical-trial-number":[{"clinical-trial-number":"chictr1800017758","registry":"10.18810\/chictr"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2268-1249","authenticated-orcid":false,"given":"Jiafeng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (J.W., X.H., M.M., T.H., Y.W., L.C., L.S., 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University, Jinan, China (W.F., M.Z., C.L., T.H., Y.W., L.C., L.S., Y.D., C.Q.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China (W.F., M.Z., C.L., T.H., Y.W., L.C., L.S., Y.D., C.Q.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China (W.F., M.Z., C.L., T.H., Y.W., L.C., L.S., Y.D., C.Q.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (J.W., X.H., M.M., T.H., Y.W., L.C., L.S., Y.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (J.W., X.H., M.M., T.H., Y.W., L.C., L.S., Y.D.)."},{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China (W.F., M.Z., C.L., T.H., Y.W., L.C., L.S., Y.D., C.Q.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8832-7301","authenticated-orcid":false,"given":"Yongxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (J.W., X.H., M.M., T.H., Y.W., L.C., L.S., Y.D.)."},{"name":"Aging Research Center and Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Sweden (Y.L., Y.W., C.Q.)."},{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China (W.F., M.Z., C.L., T.H., Y.W., L.C., L.S., Y.D., C.Q.)."},{"name":"Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China (Y.W., Y.D., C.Q.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (J.W., X.H., M.M., T.H., Y.W., L.C., L.S., Y.D.)."},{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China (W.F., M.Z., C.L., T.H., Y.W., L.C., L.S., Y.D., C.Q.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7100-1065","authenticated-orcid":false,"given":"Lin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (J.W., X.H., M.M., T.H., Y.W., L.C., L.S., Y.D.)."},{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China (W.F., M.Z., C.L., T.H., Y.W., L.C., L.S., Y.D., C.Q.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4672-6654","authenticated-orcid":false,"given":"Yifeng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (J.W., X.H., M.M., T.H., Y.W., L.C., L.S., Y.D.)."},{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China (W.F., M.Z., C.L., T.H., Y.W., L.C., L.S., Y.D., C.Q.)."},{"name":"Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China (Y.W., Y.D., C.Q.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-4912","authenticated-orcid":false,"given":"Chengxuan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Aging Research Center and Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Sweden (Y.L., Y.W., C.Q.)."},{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China (W.F., M.Z., C.L., T.H., Y.W., L.C., L.S., Y.D., C.Q.)."},{"name":"Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University & Shandong Academy of Medical 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