{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:13:23Z","timestamp":1788246803972,"version":"build-2803163510"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>The identification of patients surviving an acute intracerebral hemorrhage who are at a long-term risk of arterial thrombosis is a poorly defined, crucial issue for clinicians.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>In the setting of the MUCH-Italy (Multicenter Study on Cerebral Haemorrhage in Italy) prospective observational cohort, we enrolled and followed up consecutive 30-day intracerebral hemorrhage survivors to assess the long-term incidence of arterial thrombotic events, to assess the impact of clinical and radiological variables on the risk of these events, and to develop a tool for estimating such a risk at the individual level. Primary end point was a composite of ischemic stroke, myocardial infarction, or other arterial thrombotic events. A point-scoring system was generated by the \u03b2-coefficients of the variables independently associated with the long-term risk of arterial thrombosis, and the predictive MUCH score was calculated as the sum of the weighted scores.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Overall, 1729 patients (median follow-up time, 43 months [25th to 75th percentile, 69.0]) qualified for inclusion. Arterial thrombotic events occurred in 169 (9.7%) patients. Male sex, diabetes, hypercholesterolemia, atrial fibrillation, and personal history of coronary artery disease were associated with increased long-term risk of arterial thrombosis, whereas the use of statins and antithrombotic medications after the acute intracerebral hemorrhage was associated with a reduced risk. The area under the receiver operating characteristic curve of the MUCH score predictive validity was 0.716 (95% CI, 0.56\u20130.81) for the 0- to 1-year score, 0.672 (95% CI, 0.58\u20130.73) for the 0- to 5-year score, and 0.744 (95% CI, 0.65\u20130.81) for the 0- to 10-year score. C statistic for the prediction of events that occur from 0 to 10 years was 0.69 (95% CI, 0.64\u20130.74).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Intracerebral hemorrhage survivors are at high long-term risk of arterial thrombosis. The MUCH score may serve as a simple tool for risk estimation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.123.044626","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T05:07:49Z","timestamp":1706764069000},"page":"634-642","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Long-Term Risk of Arterial Thrombosis After Intracerebral Hemorrhage: MUCH-Italy"],"prefix":"10.1161","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8629-3315","authenticated-orcid":true,"given":"Alessandro","family":"Pezzini","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia, Universit\u00e0 degli Studi di Parma, Italy (A.P.)."},{"name":"Programma Stroke Care, Dipartimento di Emergenza-Urgenza, Azienda Ospedaliera Universitaria, Parma, Italy (A.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia","family":"Iacoviello","sequence":"additional","affiliation":[{"name":"Dipartimento di Epidemiologia e Prevenzione, IRCCS Neuromed, Pozzilli, Italy (L.I., S.C., G.G.)."},{"name":"Dipartimento di Medicina e Chirurgia (L.I.), Universit\u00e0 dell\u2019Insubria, Varese, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9767-7998","authenticated-orcid":true,"given":"Augusto","family":"Di Castelnuovo","sequence":"additional","affiliation":[{"name":"Mediterranea Cardiocentro, Napoli, Italy (A.D.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4569-1186","authenticated-orcid":true,"given":"Simona","family":"Costanzo","sequence":"additional","affiliation":[{"name":"Dipartimento di Epidemiologia e Prevenzione, IRCCS Neuromed, Pozzilli, Italy (L.I., S.C., G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6384-2561","authenticated-orcid":true,"given":"Barbara","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Sistema Nervoso e del Comportamento, Unit\u00e0 di Statistica Medica e Genomica, Universit\u00e0 di Pavia, Italy (B.T., M. Grassi)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7823-1402","authenticated-orcid":true,"given":"Giovanni","family":"de Gaetano","sequence":"additional","affiliation":[{"name":"Stroke Unit, U.O Neurologia, IRCCS Ospedale S. Raffaele, Milano, Italy (G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7530-818X","authenticated-orcid":true,"given":"Marialuisa","family":"Zedde","sequence":"additional","affiliation":[{"name":"S.C. Neurologia, Stroke Unit (M. Zedde, I.G., F.A.), AUSL-IRCCS di Reggio Emilia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-4088","authenticated-orcid":true,"given":"Simona","family":"Marcheselli","sequence":"additional","affiliation":[{"name":"Neurologia d\u2019Urgenza and Stroke Unit (S.M.), IRCCS Istituto Clinico Humanitas, Rozzano-Milano, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2060-6416","authenticated-orcid":true,"given":"Giorgio","family":"Silvestrelli","sequence":"additional","affiliation":[{"name":"Stroke Unit, Dipartimento di Neuroscienze, ASST Mantova, Italy (G.S., A. Ciccone)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4590-3575","authenticated-orcid":true,"given":"Alfonso","family":"Ciccone","sequence":"additional","affiliation":[{"name":"Stroke Unit, Dipartimento di Neuroscienze, ASST Mantova, Italy (G.S., A. Ciccone)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8530-2846","authenticated-orcid":true,"given":"Maria Luisa","family":"DeLodovici","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Neurologia, Ospedale di Circolo (M.L.D.L., L.P.C.), Universit\u00e0 dell\u2019Insubria, Varese, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-1766","authenticated-orcid":true,"given":"Lucia","family":"Princiotta Cariddi","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Neurologia, Ospedale di Circolo (M.L.D.L., L.P.C.), Universit\u00e0 dell\u2019Insubria, Varese, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5483-8795","authenticated-orcid":true,"given":"Maurizio","family":"Paciaroni","sequence":"additional","affiliation":[{"name":"Stroke Unit and Divisione di Medicina Cardiovascolare, Universit\u00e0 di Perugia, Italy (M. 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