{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T21:59:46Z","timestamp":1774130386550,"version":"3.50.1"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Spreading depolarization describes a near-complete electrical discharge with altered local cerebral blood flow. It is described in association with acute and chronic diseases like hemorrhagic stroke or migraine. Moyamoya vasculopathy is a chronic, progressive cerebrovascular disorder leading to cerebral hypoperfusion, hemodynamically insufficient basal collateralization, and increased cortical microvascularization.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>In a prospective case series, we monitored for spontaneous spreading depolarization activity by using intraoperative laser speckle imaging for real-time visualization and measurement of cortical perfusion and cerebrovascular reserve capacity during cerebral revascularization in 4 consecutive patients with moyamoya.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Spontaneous spreading depolarization occurrence was documented in a patient with moyamoya before bypass grafting. Interestingly, this patient also exhibited a marked preoperative increase in angiographic collateral vessel formation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>The spontaneous occurrence of SDs in moyamoya vasculopathy could potentially provide an explanation for localized cortical infarction and increased cortical microvascular density in these patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.123.044873","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T10:00:38Z","timestamp":1708077638000},"page":"1086-1089","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Cortical Spreading Depolarization in Moyamoya Vasculopathy: A Case Series"],"prefix":"10.1161","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1705-6556","authenticated-orcid":true,"given":"Patrick","family":"D\u00f6mer","sequence":"first","affiliation":[{"name":"Department of Neurosurgery (P.D., S.O.A.H., F.M., R.S.-P., J.W.), Carl-von-Ossietzky University Oldenburg, Germany."},{"name":"Research Center Neurosensory Science (P.D., S.O.A.H., C.M., K.W., J.W.), Carl-von-Ossietzky University Oldenburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7944-7422","authenticated-orcid":true,"given":"Simeon O.A.","family":"Helgers","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (P.D., S.O.A.H., F.M., R.S.-P., J.W.), Carl-von-Ossietzky University Oldenburg, Germany."},{"name":"Research Center Neurosensory Science (P.D., S.O.A.H., C.M., K.W., J.W.), Carl-von-Ossietzky University Oldenburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6036-4890","authenticated-orcid":true,"given":"Franziska","family":"Meinert","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (P.D., S.O.A.H., F.M., R.S.-P., J.W.), Carl-von-Ossietzky University Oldenburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e1n","family":"S\u00e1nchez-Porras","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (P.D., S.O.A.H., F.M., R.S.-P., J.W.), Carl-von-Ossietzky University Oldenburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-4958","authenticated-orcid":true,"given":"Christian","family":"Mathys","sequence":"additional","affiliation":[{"name":"Research Center Neurosensory Science (P.D., S.O.A.H., C.M., K.W., J.W.), Carl-von-Ossietzky University Oldenburg, Germany."},{"name":"Institute of Radiology and Neuroradiology, Evangelisches Krankenhaus (C.M.), Carl-von-Ossietzky University Oldenburg, Germany."},{"name":"Department of Diagnostic and Interventional Radiology, University D\u00fcsseldorf, Germany (C.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9384-3474","authenticated-orcid":true,"given":"Karsten","family":"Witt","sequence":"additional","affiliation":[{"name":"Research Center Neurosensory Science (P.D., S.O.A.H., C.M., K.W., J.W.), Carl-von-Ossietzky University Oldenburg, Germany."},{"name":"Department of Neurology (K.W.), Carl-von-Ossietzky University Oldenburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4350-392X","authenticated-orcid":true,"given":"Peter","family":"Vajkoczy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (P.V., N.H.), Charit\u00e9-Universit\u00e4tsmedizin, Germany."},{"name":"Center for Stroke Research Berlin (P.V., 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