{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:36:09Z","timestamp":1790789769193,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Mitochondrial DNA copy number (mtDNA-CN) is associated with the severity and mortality in patients with stroke, but the associations in different stroke subtypes remain unexplored.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>We conducted an observational prospective cohort analysis on patients with ischemic stroke or transient ischemic attack enrolled in the Third China National Stroke Registry. We applied logistic models to assess the association of mtDNA-CN with functional outcome (modified Rankin Scale score, 3\u20136 versus 0\u20132) and Cox proportional hazard models to assess the association with stroke recurrence (treating mortality as a competing risk) and mortality during a 12-month follow-up, adjusting for sex, age, physical activity, National Institutes of Health Stroke Scale at admission, history of stroke and peripheral artery disease, small artery occlusion, and interleukin-6. Subgroup analyses stratified by age and stroke subtypes were conducted.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              The Third China National Stroke Registry enrolled 15\u2005166 patients, of which 10\u2005241 with whole-genome sequencing data were retained (mean age, 62.2 [SD, 11.2] years; 68.8% men). The associations between mtDNA-CN and poststroke\/transient ischemic attack outcomes were specific to patients aged \u226465 years, with lower mtDNA-CN significantly associated with stroke recurrence in 12 months (subdistribution hazard ratio, 1.15 per SD lower mtDNA-CN [95% CI, 1.04\u20131.27];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =5.2\u00d710\n              <jats:sup>\u22123<\/jats:sup>\n              ) and higher all-cause mortality in 3 months (hazard ratio, 2.19 [95% CI, 1.41\u20133.39];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =5.0\u00d710\n              <jats:sup>\u22124<\/jats:sup>\n              ). Across subtypes, the associations of mtDNA-CN with stroke recurrence were specific to stroke of undetermined cause (subdistribution hazard ratio, 1.28 [95% CI, 1.11\u20131.48];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =6.6\u00d710\n              <jats:sup>\u22124<\/jats:sup>\n              ). In particular, lower mtDNA-CN was associated with poorer functional outcomes in stroke of undetermined cause patients diagnosed with embolic stroke of undetermined source (odds ratio, 1.53 [95% CI, 1.20\u20131.94];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =5.4\u00d710\n              <jats:sup>\u22124<\/jats:sup>\n              ), which remained significant after excluding patients with recurrent stroke (odds ratio, 1.49 [95% CI, 1.14\u20131.94];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =3.0\u00d710\n              <jats:sup>\u22123<\/jats:sup>\n              ).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Lower mtDNA-CN is associated with higher stroke recurrence rate and all-cause mortality, as well as poorer functional outcome at follow-up, among stroke of undetermined cause, embolic stroke of undetermined source, and younger patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.123.045069","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T05:00:26Z","timestamp":1710997226000},"page":"1261-1270","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Subtype-Specific Association of Mitochondrial DNA Copy Number With Poststroke\/TIA Outcomes in 10\u2005241 Patients in China"],"prefix":"10.1161","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1196-0280","authenticated-orcid":true,"given":"Yi","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Yi Jiang, H.W., Shanshan Cheng, C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, Z.L., Yong Jiang, X.M., H.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"Center of Excellence for Omics Research (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, H.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, Z.L., Yong Jiang, X.M., H.L., Y.W.)."},{"name":"Changping Laboratory, Beijing, China (Si Cheng, Yong Jiang, Y.W.)."},{"name":"Clinical Center for Precision Medicine in Stroke (Si Cheng, Y.W.), Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, Z.L., Yong Jiang, X.M., H.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, Z.L., Yong Jiang, X.M., H.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2559-109X","authenticated-orcid":true,"given":"Zhe","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, Z.L., Yong Jiang, X.M., H.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"Center of Excellence for Omics Research (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, H.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, Z.L., Yong Jiang, X.M., H.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Yi Jiang, H.W., Shanshan Cheng, C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanran","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, Z.L., Yong Jiang, X.M., H.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"Center of Excellence for Omics Research (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, H.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, Z.L., Yong Jiang, X.M., H.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2108-3207","authenticated-orcid":true,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, Z.L., Yong Jiang, X.M., H.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"Center of Excellence for Omics Research (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, H.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (Si Cheng, Y.S., Z.X., Y. Li, Y. 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Liu, Z.L., Yong Jiang, X.M., H.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University, China."},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (Si Cheng, Y.S., Z.X., Y. Li, Y. Liu, Z.L., Yong Jiang, X.M., H.L., Y.W.)."},{"name":"Changping Laboratory, Beijing, China (Si Cheng, Yong Jiang, Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8764-9739","authenticated-orcid":true,"given":"Xia","family":"Meng","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Diseases, Beijing (Si Cheng, Y.S., Z.X., Y. Li, Y. 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