{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:09:34Z","timestamp":1790788174617,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Periventricular white matter hyperintensities (PVWMHs) in cerebral amyloid angiopathy (CAA) have been reported posterior predominant using semiautomated segmentation method and logarithmic transformation. We aimed to compare PVWMH extent and posterior\/anterior distribution between patients with CAA and patients with hypertensive arteriopathy with radiological tools available in daily practice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>We retrospectively analyzed confluent PVWMH directly adjacent to lateral ventricles on axial FLAIR (fluid-attenuated inversion recovery) from 108 patients with CAA and 99 patients with hypertensive arteriopathy presenting with hemorrhage-related symptoms consecutively recruited in our stroke database (N\u00eemes University Hospital, France) between January 2015 and March 2022. For each of the left (L), right (R), anterior (A), and posterior (P) horns of lateral ventricles, the maximal distance between the outer PVWMH border and ventricle border was measured. The sum of anterior left PVWMH and anterior right PVWMH, and posterior left PVWMH and posterior right PVWMH resulted in anterior and posterior extent, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Compared with hypertensive arteriopathy, patients with CAA were older (median, 77 versus 71;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.0010) and less frequently male (46% versus 64%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.012) and had less frequent hypertension (45% versus 63%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.013) and more chronic hemorrhages (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.0001). CAA showed slightly more extensive anterior right PVWMH (median, 6.50 versus 5.90 mm;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.034), far more extensive (all\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.0001) posterior left PVWMH (median, 13.95 versus 6.95 mm), posterior right PVWMH (median, 14.15 versus 5.45 mm), posterior (median, 27.95 versus 13.00 mm), and total (median, 39.60 versus 24.65 mm) PVWMH, and higher posterior\/anterior ratios (median, 1.82 versus 1.01). Age-\/sex-adjusted model predicting CAA incorporating total PVWMH extent and posterior\/anterior ratios for the given score (\u22124.3683+0.0268\u00d7PVWMH-T+0.3749\u00d7posterior\/anterior PVWMH ratio+0.0394\u00d7age+0.3046 when female) showed highest area under the curve (0.76 [0.70\u20130.83]), with a 72% [62.50\u201380.99] sensitivity and 76% [67.18\u201384.12] specificity. Values above the optimal threshold of 0.22 for the score showed a crude relative risk of 2.75 (2.26\u20132.37;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.0001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Severe posterior PVWMH and high posterior\/anterior PVWMH ratio assessed by radiological tools used in daily practice are associated with probable CAA versus hypertensive arteriopathy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT05486897.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.123.046379","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T09:03:35Z","timestamp":1719392615000},"page":"2086-2093","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic Accuracy of Posterior\/Anterior Periventricular WMH Ratio to Differentiate CAA From Hypertensive Arteriopathy"],"prefix":"10.1161","volume":"55","clinical-trial-number":[{"clinical-trial-number":"nct05486897","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Louise","family":"Deasy","sequence":"first","affiliation":[{"name":"Department of Neurology (L.D., A.W., T.P., E.T., D.R.), CHU N\u00eemes, Universit\u00e9 de Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8434-014X","authenticated-orcid":true,"given":"Sabine","family":"Laurent-Chabalier","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Clinical Epidemiology, Public Health, and Innovation in Methodology (S.L.-C., T.M.), CHU N\u00eemes, Universit\u00e9 de Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3976-3772","authenticated-orcid":true,"given":"Anne","family":"Wacongne","sequence":"additional","affiliation":[{"name":"Department of Neurology (L.D., A.W., T.P., E.T., D.R.), CHU N\u00eemes, Universit\u00e9 de Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9781-8033","authenticated-orcid":true,"given":"Teodora","family":"Parvu","sequence":"additional","affiliation":[{"name":"Department of Neurology (L.D., A.W., T.P., E.T., D.R.), CHU N\u00eemes, Universit\u00e9 de Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6420-1336","authenticated-orcid":true,"given":"Thibault","family":"Mura","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Clinical Epidemiology, Public Health, and Innovation in Methodology (S.L.-C., T.M.), CHU N\u00eemes, Universit\u00e9 de Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8671-7747","authenticated-orcid":true,"given":"Eric","family":"Thouvenot","sequence":"additional","affiliation":[{"name":"Department of Neurology (L.D., A.W., T.P., E.T., D.R.), CHU N\u00eemes, Universit\u00e9 de Montpellier, France."},{"name":"Institut de G\u00e9nomique Fonctionnelle, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR) 5203, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1191, Universit\u00e9 de Montpellier, France (E.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3511-8151","authenticated-orcid":true,"given":"Dimitri","family":"Renard","sequence":"additional","affiliation":[{"name":"Department of Neurology (L.D., A.W., T.P., E.T., D.R.), CHU N\u00eemes, Universit\u00e9 de Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00131-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004797"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30079-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002362"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000732"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002352"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-325299"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.4078"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dad605"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f7450"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-023-01195-9"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15406"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.024149"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000505157"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.02.001"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.940538"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.537704"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16519"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.14.6.924"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.01.013"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26519"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00208-3"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1357506"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.028310"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2018.1480938"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.123.046379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T14:53:51Z","timestamp":1748530431000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.123.046379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1161\/STROKEAHA.123.046379"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.123.046379","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2023-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}