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Here, we describe available surgical and percutaneous approaches to achieve LAAO and discuss the available evidence for LAAO in patients with atrial fibrillation. We discuss LAAO and its role in stroke prevention in 2 frequent scenarios of cerebrovascular medicine: LAAO as a potential alternative to oral anticoagulation in patients with a history of intracranial hemorrhage or at high risk of intracranial bleeding, and LAAO as add-on therapy to direct oral anticoagulant therapy in patients with breakthrough stroke despite anticoagulation. Finally, we provide an outlook on currently ongoing trials that will provide further evidence in the next years.<\/jats:p>","DOI":"10.1161\/strokeaha.124.043867","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T09:00:14Z","timestamp":1744966814000},"page":"1928-1937","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Left Atrial Appendage Occlusion and Its Role in Stroke Prevention"],"prefix":"10.1161","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3890-3849","authenticated-orcid":true,"given":"David J.","family":"Seiffge","sequence":"first","affiliation":[{"name":"Department of Neurology, Inselspital University Hospital and University of Bern, Switzerland (D.J.S., 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