{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:36:46Z","timestamp":1790663806621,"version":"4.1.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Clinical trials of treatments for stroke have generally utilized 2-arm, randomized designs to evaluate a single intervention against a control. Running separate clinical trials, with each addressing a single therapeutic question, is resource intensive and slows evidence generation, especially in a field with rapidly expanding treatment options and evolving practices. Platform trials\u2014randomized clinical trials designed to evaluate multiple interventions that may enter and exit the ongoing platform based on a master protocol\u2014accelerate the investigation of multiple therapeutic options within a single infrastructure. This in turn has the potential to accelerate access to new interventions for patients with stroke that can save lives and improve outcomes. In the context of acute ischemic stroke, 2 new platform trials have been established, the STEP trial (StrokeNet Thrombectomy Endovascular Platform) and ACT-GLOBAL (A Multi-Factorial, Multi-Arm, Multi-Stage, Randomised, Global Adaptive Platform Trial for Stroke), to address multiple therapeutic questions simultaneously using a multifactorial design including Bayesian modeling and other adaptive features. These trials are designed to maximize the information obtained from each participant, to align clinical research more closely with the complexities of clinical care, and to accelerate the identification of effective therapies. This article explores conceptual, practical, and statistical considerations in the design and implementation of adaptive platform trials and highlights their potential to accelerate the identification of new therapies, management, and rehabilitation in stroke.<\/jats:p>","DOI":"10.1161\/strokeaha.124.045754","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T19:00:59Z","timestamp":1734721259000},"page":"198-208","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Adaptive Platform Trials in Stroke"],"prefix":"10.1161","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7259-2696","authenticated-orcid":true,"given":"Elizabeth","family":"Lorenzi","sequence":"first","affiliation":[{"name":"Berry Consultants LLC, Austin, TX (E.L., A.M.C., S.M.B., R.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-0084","authenticated-orcid":true,"given":"Amy M.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Berry Consultants LLC, Austin, TX (E.L., A.M.C., S.M.B., R.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7248-4863","authenticated-orcid":true,"given":"Craig S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, University of New South Wales, Sydney, Australia (C.S.A., X.C.)."},{"name":"Institute for Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (C.S.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijoy","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Radiology and Community Health Sciences, Cumming School of Medicine, University of Calgary, Alberta, Canada (B.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8367-542X","authenticated-orcid":true,"given":"Xiaoying","family":"Chen","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, University of New South Wales, Sydney, Australia (C.S.A., X.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7426-3650","authenticated-orcid":true,"given":"Eva","family":"Mistry","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (E.M., P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7344-8266","authenticated-orcid":true,"given":"Pooja","family":"Khatri","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (E.M., P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4893-8474","authenticated-orcid":true,"given":"Jordan J.","family":"Elm","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Medical University of South Carolina, Charleston (J.J.E., J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Beall","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Medical University of South Carolina, Charleston (J.J.E., J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6058-7171","authenticated-orcid":true,"given":"Benjamin R.","family":"Saville","sequence":"additional","affiliation":[{"name":"Adaptix Trials LLC, Austin, TX (B.R.S.)."},{"name":"Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN (B.R.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3541-0443","authenticated-orcid":true,"given":"Scott M.","family":"Berry","sequence":"additional","affiliation":[{"name":"Berry Consultants LLC, Austin, TX (E.L., A.M.C., S.M.B., R.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0020-4869","authenticated-orcid":true,"given":"Roger J.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Berry Consultants LLC, Austin, TX (E.L., A.M.C., S.M.B., R.J.L.)."},{"name":"Department of Emergency Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA) (R.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","unstructured":"Center for Biologics Evaluation and Research and Center for Drug Evaluation and Research at the U.S. Food and Drug Administration. 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