{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:20:10Z","timestamp":1790961610553,"version":"4.1.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      Limited evidence supports the effects of short-interval high-intensity interval training (HIIT) for improving cardiorespiratory fitness (V\u0307O\n                      <jats:sub>2<\/jats:sub>\n                      peak) after stroke. We aimed to compare the effects of 12 weeks of short-interval HIIT versus moderate-intensity continuous training (MICT) on V\u0307O\n                      <jats:sub>2<\/jats:sub>\n                      peak, cardiovascular risk factors, and mobility outcomes among individuals \u22656 months poststroke.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      This study was a multi-site, 12-week randomized controlled trial (NCT03614585) with an 8-week follow-up. Participants were randomized into 3 d\/wk of HIIT (10\u00d71 minute 80%\u2013100% heart rate reserve interspersed with 1 minute 30% heart rate reserve [19 minutes]) or MICT (20\u201330 minutes 40%\u201360% heart rate reserve). Secondary outcomes of the trial, including V\u0307O\n                      <jats:sub>2<\/jats:sub>\n                      peak, cardiovascular risk factors (carotid-femoral pulse wave velocity, blood pressure, and waist-hip ratio), and mobility (6-minute walk test, 10 m gait speed), were reported. Linear mixed model analyses with a group\u00d7study time point interaction evaluated between-group differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Of the 305 potential participants, 82 consented (mean [SD] age 64.9 [9.3] years, 32 females [39%], 1.8 [1.2] years poststroke) and were randomized to HIIT (n=42, mean [SD] baseline V\u0307O\n                      <jats:sub>2<\/jats:sub>\n                      peak 17.3 [5.9] mL\/kg\u00b7min) or MICT (n=40, mean [SD] baseline V\u0307O\n                      <jats:sub>2<\/jats:sub>\n                      peak 17.2 [6.0] mL\/kg\u00b7min). Participants attended 82% of visits (n=2417\/2952). No adverse events occurred during the study period. A significant group\u00d7study time point interaction was found (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      =8.46;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.015) for V\u0307O\n                      <jats:sub>2<\/jats:sub>\n                      peak at 12 weeks (mean difference, 1.81 [95% CI, 0.58\u20133.04];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.004) whereby the HIIT group had greater gains in V\u0307O\n                      <jats:sub>2<\/jats:sub>\n                      peak (\u22063.52 mL\/kg\u00b7min [95% CI, 2.47\u20134.57];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) compared with the MICT group (\u22061.71 mL\/kg\u00b7min [95% CI, 0.55\u20132.86];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001). There was no between-group difference in V\u0307O\n                      <jats:sub>2<\/jats:sub>\n                      peak (mean difference, 1.08 [95% CI, \u22120.26 to 2.42];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.11) at 8-week follow-up. No group\u00d7study time point interactions were found for cardiovascular risk factors or mobility outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      Short-interval HIIT may be an effective alternative to MICT for improving V\u0307O\n                      <jats:sub>2<\/jats:sub>\n                      peak at 12 weeks postintervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03614585.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.124.046564","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:34Z","timestamp":1723075234000},"page":"2202-2211","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["Cardiorespiratory Fitness Benefits of High-Intensity Interval Training After Stroke: A Randomized Controlled Trial"],"prefix":"10.1161","volume":"55","clinical-trial-number":[{"clinical-trial-number":"nct03614585","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9556-1630","authenticated-orcid":true,"given":"Kevin","family":"Moncion","sequence":"first","affiliation":[{"name":"School of Rehabilitation Sciences (K.M., K.S.N., E.W., P.S., J.A.R., A. Tang), Faculty of Science, McMaster University, Hamilton, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynden","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"School of Physical and Occupational Therapy, Faculty of Medicine (L.R., B.D.L.H., J.F., M.R.), McGill University, Montreal, Canada."},{"name":"Memory and Motor Rehabilitation Laboratory, Feil and Oberfeld Research Centre, Jewish Rehabilitation Hospital, Montreal Center for Interdisciplinary Research in Rehabilitation, Laval, Canada (L.R., B.D.L.H., M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8183-4696","authenticated-orcid":true,"given":"Bernat","family":"De Las Heras","sequence":"additional","affiliation":[{"name":"School of Physical and Occupational Therapy, Faculty of Medicine (L.R., B.D.L.H., J.F., M.R.), McGill University, Montreal, Canada."},{"name":"Memory and Motor Rehabilitation Laboratory, Feil and Oberfeld Research Centre, Jewish Rehabilitation Hospital, Montreal Center for Interdisciplinary Research in Rehabilitation, Laval, Canada (L.R., B.D.L.H., M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1970-430X","authenticated-orcid":true,"given":"Kenneth S.","family":"Noguchi","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Sciences (K.M., K.S.N., E.W., P.S., J.A.R., A. 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