{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:06:29Z","timestamp":1790643989921,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Patients with acute ischemic stroke harboring a large vessel occlusion admitted to nonendovascular-capable centers often require interhospital transfer for thrombectomy. We evaluated the incidence and predictors of arterial recanalization during transfer, as well as the relationship between interhospital recanalization and clinical outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>We analyzed data from 2 cohorts of patients with an anterior circulation large vessel occlusion transferred for consideration of thrombectomy to a comprehensive center, with arterial imaging at the referring hospital and on comprehensive stroke center arrival. Interhospital recanalization was determined by comparison of the baseline and posttransfer arterial imaging and was defined as revised arterial occlusive lesion (rAOL) score 2b to 3. Pretransfer variables independently associated with interhospital recanalization were studied using multivariable logistic regression analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Of the 520 included patients (Montpellier, France, n=237; Stanford, United States, n=283), 111 (21%) experienced interhospital recanalization (partial [rAOL=2b] in 77% and complete [rAOL=3] in 23%). Pretransfer variables independently associated with recanalization were intravenous thrombolysis (adjusted odds ratio, 6.8 [95% CI, 4.0\u201311.6]), more distal occlusions (intracranial carotid occlusion as reference: adjusted odds ratio, 2.0 [95% CI, 0.9\u20134.5] for proximal first segment of the middle cerebral artery, 5.1 [95% CI, 2.3\u201311.5] for distal first segment of the middle cerebral artery, and 5.0 [95% CI, 2.1\u201311.8] for second segment of the middle cerebral artery), and smaller clot burden (clot burden score 0\u20134 as reference: adjusted odds ratio, 3.4 [95% CI, 1.5\u20137.6] for 5\u20137 and 5.6 [95% CI, 2.4\u201312.7] for 8\u20139). Recanalization on arrival at the comprehensive center was associated with less interhospital infarct growth (rAOL, 0\u20132a: 11.6 mL; rAOL, 2b: 2.2 mL; rAOL, 3: 0.6 mL;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              &lt;0.001) and greater interhospital National Institutes of Health Stroke Scale score improvement (0 versus \u22125 versus \u22126;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              &lt;0.001). Interhospital recanalization was associated with reduced 3-month disability (adjusted common odds ratio, 2.51 [95% CI, 1.68\u20133.77]) with greater benefit from complete than partial recanalization.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Recanalization is frequently observed during interhospital transfer for thrombectomy and is strongly associated with favorable outcomes, even when partial. Broadening thrombolysis indications in primary centers, and developing therapies that increase recanalization during transfer, will likely improve clinical outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.124.046694","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T13:01:11Z","timestamp":1715864471000},"page":"1525-1534","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Arterial Recanalization During Interhospital Transfer for Thrombectomy"],"prefix":"10.1161","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2134-0691","authenticated-orcid":true,"given":"Pierre","family":"Seners","sequence":"first","affiliation":[{"name":"Stanford Stroke Center, Palo Alto, CA (P.S., A.W., N.Y., M.M., S.K., S.C., M.G.L., G.W.A.)."},{"name":"Neurology Department, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France (P.S.)."},{"name":"Institut de Psychiatrie et Neurosciences de Paris, U1266, INSERM, Paris, France (P.S., C.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-2699","authenticated-orcid":true,"given":"Anke","family":"Wouters","sequence":"additional","affiliation":[{"name":"Stanford Stroke Center, Palo Alto, CA (P.S., A.W., N.Y., M.M., S.K., S.C., M.G.L., G.W.A.)."},{"name":"Division of Experimental Neurology, Department of Neurosciences, KU Leuven, Belgium (A.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7354-3351","authenticated-orcid":true,"given":"Adrien","family":"Ter Schiphorst","sequence":"additional","affiliation":[{"name":"Neurology Department (A.T.S., C.A.), CHRU Gui de Chauliac, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3206-6656","authenticated-orcid":true,"given":"Nicole","family":"Yuen","sequence":"additional","affiliation":[{"name":"Stanford Stroke Center, Palo Alto, CA (P.S., A.W., N.Y., M.M., S.K., S.C., M.G.L., G.W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7483-8699","authenticated-orcid":true,"given":"Michael","family":"Mlynash","sequence":"additional","affiliation":[{"name":"Stanford Stroke Center, Palo Alto, CA (P.S., A.W., N.Y., M.M., S.K., S.C., M.G.L., G.W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7347-1039","authenticated-orcid":true,"given":"Caroline","family":"Arquizan","sequence":"additional","affiliation":[{"name":"Institut de Psychiatrie et Neurosciences de Paris, U1266, INSERM, Paris, France (P.S., C.A.)."},{"name":"Neurology Department (A.T.S., C.A.), CHRU Gui de Chauliac, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy J.","family":"Heit","sequence":"additional","affiliation":[{"name":"Radiology Department, Stanford University, Palo Alto, CA (J.J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Kemp","sequence":"additional","affiliation":[{"name":"Stanford Stroke Center, Palo Alto, CA (P.S., A.W., N.Y., M.M., S.K., S.C., M.G.L., G.W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1242-3724","authenticated-orcid":true,"given":"Soren","family":"Christensen","sequence":"additional","affiliation":[{"name":"Stanford Stroke Center, Palo Alto, CA (P.S., A.W., N.Y., M.M., S.K., S.C., M.G.L., G.W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-7119","authenticated-orcid":true,"given":"Denis","family":"Sablot","sequence":"additional","affiliation":[{"name":"Neurology Department, CH Perpignan, Perpignan, France (D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3976-3772","authenticated-orcid":true,"given":"Anne","family":"Wacongne","sequence":"additional","affiliation":[{"name":"Neurology Department, CHU Nimes, France (A.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Lalu","sequence":"additional","affiliation":[{"name":"Neurology Department, CH B\u00e9ziers, France (T.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Costalat","sequence":"additional","affiliation":[{"name":"Neuroradiology Department (V.C.), CHRU Gui de Chauliac, Montpellier, 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